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Total 1564 results found since Jan 2013.
Early Ultrafast Ultrasound Imaging of Cerebral Perfusion correlates with Ischemic Stroke outcomes and responses to treatment in Mice
Conclusion: We thus provide the proof of concept that in a mouse model of thromboembolic stroke with an intact skull, early ultrafast ultrasound can be indicative of responses to treatment and cerebral tissue fates following stroke. It brings new tools to study ischemic stroke in preclinical models and is the first step prior translation to the clinical settings.
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Vincent Hingot, Camille Brodin, Florent Lebrun, Baptiste Heiles, Audrey Chagnot, Merv é Yetim, Maxime Gauberti, Cyrille Orset, Mickael Tanter, Olivier Couture, Thomas Deffieux, Denis Vivien Tags: Research Paper Source Type: research
Circulating Exosomes of Neuronal Origin as Potential Early Biomarkers for Development of Stroke
AbstractStroke is one of the major causes of morbidity and mortality globally, with devastating effects. It is diagnosed mainly by clinical assessment and brain imaging; however, it is challenging to discriminate stroke from similar conditions with parallel presentations. While brain imaging provides detection of stroke infarcts, it does not provide useful information on the biology and prognosis of the underlying disease process. The complex pathophysiology of stroke infarcts is a barrier in developing sensitive diagnostic tools, which consequently has a detrimental effect on development of treatment regimens. Early diagn...
Source: Molecular Diagnosis and Therapy - January 16, 2021 Category: Molecular Biology Source Type: research
Systemic inflammation after stroke: implications for post-stroke comorbidities
EMBO Mol Med. 2022 Aug 15:e16269. doi: 10.15252/emmm.202216269. Online ahead of print.ABSTRACTImmunological mechanisms have come into the focus of current translational stroke research, and the modulation of neuroinflammatory pathways has been identified as a promising therapeutic approach to protect the ischemic brain. However, stroke not only induces a local neuroinflammatory response but also has a profound impact on systemic immunity. In this review, we will summarize the consequences of ischemic stroke on systemic immunity at all stages of the disease, from onset to long-term outcome, and discuss underlying mechanisms...
Source: Molecular Medicine - August 16, 2022 Category: Molecular Biology Authors: Alba Simats Arthur Liesz Source Type: research
New insights into circRNA and its mechanisms in angiogenesis regulation in ischemic stroke: a biomarker and therapeutic target
Mol Biol Rep. 2022 Nov 4. doi: 10.1007/s11033-022-07949-2. Online ahead of print.ABSTRACTIschemic stroke accounts for about 71% of strokes worldwide. Due to limited recommended therapeutics for ischemic stroke, more attention is focused on angiogenesis in ischemic stroke. Not long after ischemic stroke, angiogenesis arises and is vital for the prognosis. Various pro-angiogenic, anti-angiogenic factors and their downstream pathways engage in angiogenesis regulation. CircRNAs are differentially expressed after ischemic stroke. Up to now, circRNAs have been found to exert many functions in regulating apoptosis, autophagy, pro...
Source: Molecular Biology Reports - November 4, 2022 Category: Molecular Biology Authors: Liuyang Cheng Zeyu Liu Jian Xia Source Type: research
Association between the MMP-9-1562 C>T polymorphism and the risk of stroke: a meta-analysis.
Association between the MMP-9-1562 C>T polymorphism and the risk of stroke: a meta-analysis.
Mol Biol Rep. 2014 Jul 11;
Authors: Fan ZZ, Ge ZM, Cai HB, Liu ZY, Liu P, Wang HY
Abstract
Matrix metalloproteinase (MMP)-9 so far is identified as extremely large and complicated MMP family member. Recently, dozens of studies have explored the association between a promoter polymorphism (-1562 C>T) in MMP-9 and stroke susceptibility. However, the conclusions of these studies still remain equivocal. Therefore, our current meta-analysis was conducted to investigate whether or not the MMP-9 promoter polymo...
Source: Molecular Biology Reports - July 11, 2014 Category: Molecular Biology Authors: Fan ZZ, Ge ZM, Cai HB, Liu ZY, Liu P, Wang HY Tags: Mol Biol Rep Source Type: research
Electroacupuncture promotes neural stem cell proliferation and neurogenesis in the dentate gyrus of rats following stroke via upregulation of Notch1 expression.
In conclusion, to the best of our knowledge, the present study was the first to demonstrate that EA treatment promoted NSC proliferation and neurogenesis in the DG area through the upregulation of Notch signaling following a stroke; therefore, EA may be a useful novel therapeutic strategy in future stroke treatment.
PMID: 26328605 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - September 4, 2015 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Temporal profiles of blood pressure, circulating nitric oxide, and adrenomedullin as predictors of clinical outcome in acute ischemic stroke patients.
Authors: Serrano-Ponz M, Rodrigo-Gasqué C, Siles E, MartÃnez-Lara E, Ochoa-Callejero L, MartÃnez A
Abstract
Stroke remains an important health and social challenge. The present study investigated whether blood pressure (BP) parameters and circulating levels of nitric oxide metabolites (NOx) and adrenomedullin (AM) may predict clinical outcomes of stroke. Patients (n=76) diagnosed with acute ischemic stroke were admitted to the stroke unit and clinical history data and monitored parameters were recorded. Blood plasma was collected at days 1, 2, and 7 to measure NOx and AM levels. Infarct volume, neurological sev...
Source: Molecular Medicine Reports - April 3, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Quercetin protects against heat stroke-induced myocardial injury in male rats: Antioxidative and antiinflammatory mechanisms.
Abstract
Heat stroke is characterilized by hyperthermia, systemic inflammation, and multiple organ failure including arterial hypotension. This definition can be fulfilled by a rat model of heat stroke used in the present study. Anesthetized animals were exposed to heat exposure (43 °C for 70 min) and then returned to room temperature (26 °C) for recovery. One hour before heat exposure, an intraperitoneal dose of quercetin (30 mg/kg) or vehicle (normal saline 1 ml/kg) was administered to the experimental groups of rats. Additional injection was administered immediately after the onset of heat stroke. Immedi...
Source: Chemico-Biological Interactions - January 15, 2017 Category: Molecular Biology Authors: Lin X, Lin CH, Zhao T, Zuo D, Ye Z, Liu L, Lin MT Tags: Chem Biol Interact Source Type: research
Identification of six polymorphisms as novel susceptibility loci for ischemic or hemorrhagic stroke by exome-wide association studies.
In this study, we performed exome-wide association studies (EWASs) to identify genetic variants that confer susceptibility to ischemic stroke, intracerebral hemorrhage (ICH), or subarachnoid hemorrhage (SAH). EWAS for ischemic stroke was performed using 1,575 patients with this condition and 9,210 controls, and EWASs for ICH and SAH were performed using 673 patients with ICH, 265 patients with SAH and 9,158 controls. Analyses were performed with Illumina HumanExome-12 DNA Analysis BeadChip or Infinium Exome-24 BeadChip arrays. The relation of allele frequencies for 41,339 or 41,332 single nucleotide polymorphismsÂ...
Source: International Journal of Molecular Medicine - May 13, 2017 Category: Molecular Biology Authors: Yamada Y, Sakuma J, Takeuchi I, Yasukochi Y, Kato K, Oguri M, Fujimaki T, Horibe H, Muramatsu M, Sawabe M, Fujiwara Y, Taniguchi Y, Obuchi S, Kawai H, Shinkai S, Mori S, Arai T, Tanaka M Tags: Int J Mol Med Source Type: research
ALOX5AP rs10507391 polymorphism and the risk of ischemic stroke in Caucasians: an update meta-analysis.
In conclusion, this study found that ALOX5AP rs10507391 polymorphism was associated with ischemic stroke risk in Caucasians.
PMID: 29096760 [PubMed - in process]
Source: Cellular and Molecular Biology - November 5, 2017 Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research
Cryptotanshinone exhibits therapeutical effects on cerebral stroke through the PI3K/AKT ‑eNOS signaling pathway.
In conclusion, CPT exhibited a protective effect against cerebral stroke through inhibition of the PI3K/AKT‑eNOS signaling pathway. These results suggested the potential of CPT as a promising agent in the treatment of cerebral stroke.
PMID: 29152647 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - November 22, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Common variants of ROCKs and the risk of hypertension, and stroke: Two case-control studies and a follow-up study in Chinese Han population
Publication date: March 2018 Source:Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Volume 1864, Issue 3 Author(s): Song Yang, Yanping Zhao, Yuanrui Tian, Yanchun Chen, Xianghai Zhao, Ying Li, Hailong Zhao, Xiaotian Chen, Lijun Zhu, Zhengmei Fang, YingShui Yao, Zhibing Hu, Chong Shen The Rho kinases (ROCKs) are recognized as a critical regulator of vascular functions in cardiovascular disorders. It is crucial to illustrate the association of ROCKs genetic variation and hypertension and/or stroke events. Herein we aimed at investigating the association of ROCK1 and ROCK2 with hypertension and stroke in Ch...
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - January 4, 2018 Category: Molecular Biology Source Type: research
Evaluation of serum levels of homocysteine and C-reactive protein in patients with ischemic stroke
Cell Mol Biol (Noisy-le-grand). 2022 Jul 31;68(7):56-62. doi: 10.14715/cmb/2022.68.7.10.ABSTRACTStroke is the third most common cause of death in the world. Plasma homocysteine is an emerging risk factor for stroke. Also, previous studies have shown that serum levels of C-reactive protein (CRP) are significantly associated with mortality and function in patients with ischemic stroke. In the present study, we examined homocysteine and serum CRP levels in patients with ischemic stroke. This descriptive-analytical study was performed on 100 patients with ischemic stroke. Blood samples were taken in the first 24 hours of a str...
Source: Cellular and Molecular Biology - December 10, 2022 Category: Molecular Biology Authors: Liu Yang Bing Xu Source Type: research
