Filtered By:
Specialty: Allergy & Immunology

This page shows you your search results in order of relevance.

Order by Relevance | Date

Total 749 results found since Jan 2013.

Immune responses in stroke: How the immune system contributes to damage and healing after stroke and how this knowledge could be translated to better cures?
This article is protected by copyright. All rights reserved. PMID: 29494762 [PubMed - as supplied by publisher]
Source: Immunology - March 1, 2018 Category: Allergy & Immunology Authors: Rayasam A, Hsu M, Kijak JA, Kissel L, Hernandez G, Sandor M, Fabry Z Tags: Immunology Source Type: research

Brain-Derived Microparticles (BDMPs) Contribute to Neuroinflammation and Lactadherin Reduces BDMP Induced Neuroinflammation and Improves Outcome After Stroke
In this study, we investigate whether BDMP affects stroke-induced neuroinflammation and whether Lactadherin treatment reduces stroke initiated BDMP-induced neuroinflammation, thereby improving functional outcome after stroke. Middle aged (8–9 months old) male C57BL/6J mice were subjected to distal middle cerebral artery occlusion (dMCAo) stroke, and BDMPs were extracted from ischemic brain 24 h after dMCAo by ultracentrifugation. Adult male C57BL/6J mice were subjected to dMCAo and treated via tail vein injection at 3 h after stroke with: (A) +PBS (n = 5/group); (B) +BDMPs (1.5 × 108, n = 6/group); (C) +Lactadherin (400...
Source: Frontiers in Immunology - November 25, 2019 Category: Allergy & Immunology Source Type: research

Association of Serum Levels of Pentraxin-3, M-ficolin, and Surfactant Protein A with the Severity of Ischemic Stroke.
Abstract Stroke is one of the most leading causes of death and disability in the world. Complement system activation contributes to pathogenesis and neuronal damage following stroke. There are no defined biological serum markers to determine the severity of stroke in acute phases. The purpose of current study was to determine the association of three complement activators, namely Pentraxin-3 (PTX3),M-ficolin, and Surfactant protein A (SPA) with the severity of ischemic stroke. This cross-sectional study was done on 82 patients diagnosed with ischemic stroke at 24-96 hours of initiation of the clinical symptoms dur...
Source: Iranian Journal of Allergy, Asthma and Immunology - April 1, 2017 Category: Allergy & Immunology Authors: Kouchaki E, Babamohammadi A, Nikoueinejad H, Sehat M Tags: Iran J Allergy Asthma Immunol Source Type: research

Lung Imaging Reveals Stroke-Induced Impairment in  Pulmonary Intravascular Neutrophil Function, a Response Exacerbated with Aging
In this study, using an experimental mouse model of ischemic stroke, we showed that older (12-15 mo of age) mice had elevated lung bacterial infection and inflammatory damage after stroke when compared with young (8-10 wk of age) counterparts, despite undergoing the same degree of brain injury. Intravital microscopy of the lung microvasculature revealed that in younger mice, stroke promoted neutrophil arrest in pulmonary microvessels, but this response was not seen in older poststroke mice. In addition, bacterial phagocytosis by neutrophils in the lung microvasculature was reduced by both aging and stroke, such that neutro...
Source: Journal of Immunology - April 2, 2022 Category: Allergy & Immunology Authors: Shu Wen Wen Raymond Shim Pam Hall Justin Bedo Jenny L Wilson Alyce J Nicholls Michael J Hickey Connie H Y Wong Source Type: research

Influenza and pneumococcal vaccination and risk of stroke or transient ischaemic attack-Matched case control study.
CONCLUSIONS: Influenza vaccination was associated with a 24% reduction in risk of stroke but not TIA. Pneumococcal vaccination was not associated with reduced risk of stroke or TIA. This has important implications for potential benefits of influenza vaccine. PMID: 24486370 [PubMed - as supplied by publisher]
Source: Vaccine - January 28, 2014 Category: Allergy & Immunology Authors: Siriwardena AN, Asghar Z, Coupland CA Tags: Vaccine Source Type: research

Role of N-Terminal Pro-B-Type Natriuretic Peptide, High-Sensitivity C-Reactive Protein, and Inteleukin-6 in Predicting a Poor Outcome after a Stroke
Conclusions: In acute stroke patients, greater NT-proBNP and hsCRP serum concentrations are independently associated with greater clinical stroke severity. Elevated concentrations of IL-6 and hsCRP are associated with worse functional and cognitive outcomes at discharge, respectively.Neuroimmunomodulation
Source: Neuroimmunomodulation - May 8, 2015 Category: Allergy & Immunology Source Type: research

Glial Cells: Role of the Immune Response in Ischemic Stroke
Ischemic stroke, which accounts for 75–80% of all strokes, is the predominant cause of morbidity and mortality worldwide. The post-stroke immune response has recently emerged as a new breakthrough target in the treatment strategy for ischemic stroke. Glial cells, including microglia, astrocytes, and oligodendrocytes, are the primary components of the peri-infarct environment in the central nervous system (CNS) and have been implicated in post-stroke immune regulation. However, increasing evidence suggests that glial cells exert beneficial and detrimental effects during ischemic stroke. Microglia, which survey CNS homeost...
Source: Frontiers in Immunology - February 25, 2020 Category: Allergy & Immunology Source Type: research

Dysregulated Hypothalamic –Pituitary–Adrenal Axis Is Associated With Increased Inflammation and Worse Outcomes After Ischemic Stroke in Diabetic Mice
Diabetic patients have larger infarcts, worse neurological deficits, and higher mortality rate after an ischemic stroke. Evidence shows that in diabetes, the hypothalamic–pituitary–adrenal (HPA) axis was dysregulated and levels of cortisol increased. Based on the role of the HPA axis in immunity, we hypothesized that diabetes-dysregulated stress response exacerbates stroke outcomes via regulation of inflammation. To test this hypothesis, we assessed the regulation of the HPA axis in diabetic mice before and after stroke and determined its relevance in the regulation of post-stroke injury and inflammation. Diabetes was ...
Source: Frontiers in Immunology - June 16, 2022 Category: Allergy & Immunology Source Type: research

Influenza vaccination and risk of stroke: Self-controlled case-series study.
CONCLUSIONS: Influenza vaccination is associated with a reduction in incidence of stroke. This study supports previous studies which have shown a beneficial association of influenza vaccination for stroke prevention. PMID: 26296496 [PubMed - as supplied by publisher]
Source: Vaccine - August 18, 2015 Category: Allergy & Immunology Authors: Asghar Z, Coupland C, Siriwardena N Tags: Vaccine Source Type: research

Antiphospholipid antibodies correlate with stroke severity and outcome in patients with antiphospholipid syndrome.
CONCLUSIONS: In young stroke patients with APS, serum levels of IgM aCL within 48 h are correlated with stroke severity and levels of IgG anti-β2GPI within 48 h are correlated with three-month outcomes. PMID: 25434364 [PubMed - in process]
Source: Autoimmunity - February 17, 2016 Category: Allergy & Immunology Tags: Autoimmunity Source Type: research

Ischemic stroke in giant-cell arteritis: French retrospective study.
This study shows the prevalence and risk factors of ischemic stroke in GCA. PMID: 30737054 [PubMed - as supplied by publisher]
Source: Journal of Autoimmunity - February 5, 2019 Category: Allergy & Immunology Authors: Pariente A, Guédon A, Alamowitch S, Thietart S, Carrat F, Delorme S, Capron J, Cacciatore C, Soussan M, Dellal A, Fain O, Mekinian A Tags: J Autoimmun Source Type: research

Short Chain Fatty Acids Taken at Time of Thrombectomy in Acute Ischemic Stroke Patients Are Independent of Stroke Severity But Associated With Inflammatory Markers and Worse Symptoms at Discharge
ConclusionsPlasma SCFA concentrations taken at time of stroke are not associated with stroke severity at presentation. However, higher levels of SCFAs at the time of stroke are associated with increased markers of inflammation, less recovery from admission to discharge, and worse symptom burden at discharge.
Source: Frontiers in Immunology - January 19, 2022 Category: Allergy & Immunology Source Type: research

4-Ethylguaiacol modulates neuroinflammation and promotes heme oxygenase-1 expression to ameliorate brain injury in ischemic stroke
Ischemic stroke is caused by a sudden reduction in cerebral blood flow that subsequently induces a complex cascade of pathophysiological responses, leading to brain inflammation and irreversible infarction. 4-ethylguaiacol (4-EG) is reported to suppress inflammatory immune responses. However, whether 4-EG exerts anti-inflammatory effects in ischemic stroke remains unexplored. We evaluated the therapeutic potential of 4-EG, and examined the cellular and molecular mechanisms underlying the protective effects of 4-EG in ischemic stroke. The effect of 4-EG in ischemic stroke was determined by using transient middle cerebral ar...
Source: Frontiers in Immunology - July 1, 2022 Category: Allergy & Immunology Source Type: research