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Specialty: Allergy & Immunology
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Total 749 results found since Jan 2013.
Gut microbial metabolite TMAO portends prognosis in acute ischemic stroke
Over the recent years, the role of trimethylamine N-oxide (TMAO) as a gut-derived metabolite mediating cardiovascular disease pathogenesis has been under particularly intense scrutiny. The aim was to explore whether TMAO levels were associated with clinical severity or functional outcome in Chinese patients with ischemic stroke.
Source: Journal of Neuroimmunology - February 20, 2021 Category: Allergy & Immunology Authors: Jianli Zhang, Liankun Wang, Jinle Cai, Aidi Lei, Caiwen Liu, Ruidian Lin, Li Jia, Yingzi Fu Source Type: research
Exosomes Derived From Heat Stroke Cases Carry miRNAs Associated With Inflammation and Coagulation Cascade
In this study, we evaluate the presence of microRNAs (miRNAs) and messenger RNAs (mRNAs) associated with inflammatory responses and coagulation cascade in exosomes of patients with HS. Blood samples were collected from three patients with HS at the time of admission to the intensive care unit; three healthy volunteers were selected as control. Exosomes were isolated using ultracentrifugation, and their miRNA content was profiled using next-generation sequencing; mRNA content was evaluated using qPCR array. Compared with those from healthy volunteers, exosomes from patients with HS showed substantial changes in the expressi...
Source: Frontiers in Immunology - June 22, 2021 Category: Allergy & Immunology Source Type: research
Increased serum interleukin-34 levels as a novel diagnostic and prognostic biomarker in patients with acute ischemic stroke
Recent data reveal that interleukin-34 (IL-34) can drive inflammatory response, thereby participating in the pathogenesis of inflammatory diseases. However, the potential effect of IL-34 in acute ischemic stroke (AIS) remains unknown. The purpose of this study was to explore whether the levels of serum IL-34 were correlated with clinical severity or prognosis in AIS patients.
Source: Journal of Neuroimmunology - June 29, 2021 Category: Allergy & Immunology Authors: Xiaoyu Huang, Fengzhan Li, Tingting Yang, Hao Li, Tan Liu, Yingying Wang, Minmin Xu, Lisha Yan, Yong Zhang, Yuzhong Wang, Linlin Fu, Deqin Geng Source Type: research
MicroRNA-532-5p upregulation protects neurological deficits after ischemic stroke through inhibition of BTB and CNC homology 1
CONCLUSION: MiR-532-5p upregulation protects against neurological deficits after IS through inhibition of BACH1.PMID:34464885 | DOI:10.1016/j.intimp.2021.108003
Source: International Immunopharmacology - August 31, 2021 Category: Allergy & Immunology Authors: Jing Wang Bin Han Xiaoli Zhao Yaxuan Sun Yi Liu Fengyun Hu Kun Meng Source Type: research
Cytosolic p53 Inhibits Parkin-Mediated Mitophagy and Promotes Acute Liver Injury Induced by Heat Stroke
Heat stroke (HS) is a severe condition characterized by increased morbidity and high mortality. Acute liver injury (ALI) is a well-documented complication of HS. The tumor suppressor p53 plays an important role in regulation of mitochondrial integrity and mitophagy in several forms of ALI. However, the role of p53-regulated mitophagy in HS-ALI remains unclear. In our study, we discovered the dynamic changes of mitophagy in hepatocytes and demonstrated the protective effects of mitophagy activation on HS-ALI. Pretreatment with 3-MA or Mdivi-1 significantly exacerbated ALI by inhibiting mitophagy in HS-ALI mice. Consistent w...
Source: Frontiers in Immunology - May 13, 2022 Category: Allergy & Immunology Source Type: research
Inflammatory profile and white matter hyperintensity burden in acute ischemic stroke patients
Inflammation is involved in small vessel disease (SVD). We aim to clarify whether inflammation related to white matter hyperintensities (WMH), a key component of SVD, may affect the inflammatory response in acute ischemic stroke (AIS) patients. For this, we sequentially measured 10 circulating inflammatory markers and assessed WMH burden on admission MRI in AIS patients treated with thrombectomy. Of 149 patients, 57 (38.3%) had a high WMH burden (Fazekas ≥3). A high WMH burden was associated with 4 markers levels but this association did not remain following multivariable analyses.
Source: Journal of Neuroimmunology - July 28, 2022 Category: Allergy & Immunology Authors: Lucie Rascle, Norbert Nighoghossian, Tae-Hee Cho, Thomas Bochaton, Alexandre Paccalet, Claire Crola Da Silva, Marielle Buisson, Camille Amaz, Julia Fontaine, Elodie Ong, Laurent Derex, Yves Berthezene, Omer Faruk Eker, Nathan Mewton, Michel Ovize, Laura M Tags: Short Communication Source Type: research
A novel aGAPSS-based nomogram for the prediction of ischemic stroke in patients with antiphospholipid syndrome
ConclusionAge, diabetes, hyperuricemia, the platelet count, and the aGAPSS were risk factors for IS in patients with APS. The aGAPSS-IS may be a good tool for IS risk stratification for patients with APS based on routinely available data.
Source: Frontiers in Immunology - July 29, 2022 Category: Allergy & Immunology Source Type: research
Microglia autophagy in ischemic stroke: A double-edged sword
Ischemic stroke (IS) is one of the major types of cerebrovascular diseases causing neurological morbidity and mortality worldwide. In the pathophysiological process of IS, microglia play a beneficial role in tissue repair. However, it could also cause cellular damage, consequently leading to cell death. Inflammation is characterized by the activation of microglia, and increasing evidence showed that autophagy interacts with inflammation through regulating correlative mediators and signaling pathways. In this paper, we summarized the beneficial and harmful effects of microglia in IS. In addition, we discussed the interplay ...
Source: Frontiers in Immunology - November 16, 2022 Category: Allergy & Immunology Source Type: research
Calcitriol modulate post-ischemic TLR signaling pathway in ischemic stroke patients
This study aimed to determine the modulat ory effects of calcitriol hormone on post-ischemic immunity response.
Source: Journal of Neuroimmunology - December 26, 2022 Category: Allergy & Immunology Authors: Saeedeh Tajalli-Nezhad, Salimeh Mohammadi, Mohammad Ali Atlasi, Mahdi Kheiran, Sepideh Etehadi Moghadam, Homayoun Naderian, Abolfazl Azami Tameh Source Type: research
Escin alleviates stress-induced intestinal dysfunction to protect brain injury by regulating the gut-brain axis in ischemic stroke rats
Int Immunopharmacol. 2023 Jan 4;115:109659. doi: 10.1016/j.intimp.2022.109659. Online ahead of print.ABSTRACTHyperactivity of HPA axis results in intestinal dysfunction, which may play a role in brain injury caused by ischemic stroke (IS). Escin shows a neuroprotective effect but it may not penetrate blood brain barrier (BBB). Previous work in our laboratory showed that escin ameliorated intestinal injury in animals. The aim of this study is to investigate whether escin attenuates brain injury by improving intestinal dysfunction in middle cerebral artery occlusion (MCAO) rats, to mimic IS. MCAO rats and lipopolysaccharides...
Source: International Immunopharmacology - January 6, 2023 Category: Allergy & Immunology Authors: Min Li Shengguang Wang Ce Zhang Chenglin Chi Rongxia Liu Tian Wang Fenghua Fu Source Type: research
The mechanism of microglia-mediated immune inflammation in ischemic stroke and the role of natural botanical components in regulating microglia: A review
Ischemic stroke (IS) is one of the most fatal diseases. Neuroimmunity, inflammation, and oxidative stress play important roles in various complex mechanisms of IS. In particular, the early proinflammatory response resulting from the overactivation of resident microglia and the infiltration of circulating monocytes and macrophages in the brain after cerebral ischemia leads to secondary brain injury. Microglia are innate immune cells in the brain that constantly monitor the brain microenvironment under normal conditions. Once ischemia occurs, microglia are activated to produce dual effects of neurotoxicity and neuroprotectio...
Source: Frontiers in Immunology - February 2, 2023 Category: Allergy & Immunology Source Type: research
Crosstalk between oxidative stress and neutrophil response in early ischemic stroke: a comprehensive transcriptome analysis
ConclusionWe identified 6 critical genes, STAT3, FPR1, AQP9, SELL, MMP9 and IRAK3, related to oxidative stress and neutrophil response in early IS, which may provide new insights into understanding the pathophysiological mechanism of IS. We hope our analysis could help develop novel diagnostic biomarkers and therapeutic strategies for IS.
Source: Frontiers in Immunology - April 26, 2023 Category: Allergy & Immunology Source Type: research
Neutrophil percentage to albumin ratio is associated with stroke-associated pneumonia and poor outcome in patients with spontaneous intracerebral hemorrhage
ConclusionHigher NPAR is independently associated with SAP and poor functional outcome in patients with ICH. Our findings suggest that early prediction of SAP is feasible by using a simple biomarker NPAR.
Source: Frontiers in Immunology - June 14, 2023 Category: Allergy & Immunology Source Type: research
Ischemic stroke-related gene expression profiles across species: a meta-analysis
Stroke patients are often left with permanent disabilities with no regenerative treatment options. Unbiased RNA sequencing studies decoding the transcriptional signature of stroked tissue hold promise to ident...
Source: Journal of Inflammation - June 19, 2023 Category: Allergy & Immunology Authors: Ruslan Rust Tags: Brief Report Source Type: research
Identification of cell death-related biomarkers and immune infiltration in ischemic stroke between male and female patients
ConclusionThese findings contribute to a better knowledge of immune cell infiltration and their corresponding molecular mechanisms of cell death and offer distinct clinically relevant biological targets for IS patients of different genders.
Source: Frontiers in Immunology - June 26, 2023 Category: Allergy & Immunology Source Type: research
