Inflammatory profile and white matter hyperintensity burden in acute ischemic stroke patients

Inflammation is involved in small vessel disease (SVD). We aim to clarify whether inflammation related to white matter hyperintensities (WMH), a key component of SVD, may affect the inflammatory response in acute ischemic stroke (AIS) patients. For this, we sequentially measured 10 circulating inflammatory markers and assessed WMH burden on admission MRI in AIS patients treated with thrombectomy. Of 149 patients, 57 (38.3%) had a high WMH burden (Fazekas ≥3). A high WMH burden was associated with 4 markers levels but this association did not remain following multivariable analyses.

Source: Journal of Neuroimmunology - July 28, 2022 Category: Allergy & Immunology Authors: Lucie Rascle, Norbert Nighoghossian, Tae-Hee Cho, Thomas Bochaton, Alexandre Paccalet, Claire Crola Da Silva, Marielle Buisson, Camille Amaz, Julia Fontaine, Elodie Ong, Laurent Derex, Yves Berthezene, Omer Faruk Eker, Nathan Mewton, Michel Ovize, Laura M Tags: Short Communication Source Type: research