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Specialty: Allergy & Immunology

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Total 749 results found since Jan 2013.

Edaravone dexborneol provides neuroprotective benefits by suppressing NLRP3 inflammasome-induced microglial pyroptosis in experimental ischemic stroke
In this study, we investigated the therapeutic effects and potential mechanisms of EDB in acute ischemic stroke. We used an in vivo mouse transient middle cerebral artery occlusion (tMCAO) model along with an in vitro BV2 cell oxygen-glucose deprivation (OGD) model to perform specific experiments. The executive protein of pyroptosis, gasdermin D (GSDMD), was increased after tMCAO. The administration of EDB dramatically reduced sensorimotor deficits and infarct sizes in mice with tMCAO. In addition, EDB inhibited the production of the NLRP3-inflammasome and the activation of the NF-κB signaling pathway. This effect inhibit...
Source: International Immunopharmacology - October 24, 2022 Category: Allergy & Immunology Authors: Ruiyao Hu Jing Liang Lan Ding Wan Zhang Xinjing Liu Bo Song Yuming Xu Source Type: research

Electroacupuncture and human iPSC-derived small extracellular vesicles regulate the gut microbiota in ischemic stroke via the brain-gut axis
Electroacupuncture (EA) and induced pluripotent stem cell (iPSC)-derived small extracellular vesicles (iPSC-EVs) have substantial beneficial effects on ischemic stroke. However, the detailed mechanisms remain unclear. Here, we explored the mechanisms underlying the regulation of EA and iPSC-EVs in the microbiome-gut-brain axis (MGBA) after ischemic stroke. Ischemic stroke mice (C57BL/6) were subjected to middle cerebral artery occlusion (MCAO) or Sham surgery. EA and iPSC-EVs treatments significantly improved neurological function and neuronal and intestinal tract injury, downregulated the levels of IL-17 expression and up...
Source: Frontiers in Immunology - January 20, 2023 Category: Allergy & Immunology Source Type: research

Immune regulation based on sex differences in ischemic stroke pathology
Ischemic stroke is one of the world’s leading causes of death and disability. It has been established that gender differences in stroke outcomes prevail, and the immune response after stroke is an important factor affecting patient outcomes. However, gender disparities lead to different immune metabolic tendencies closely related to immune regulation after stroke. The present review provides a comprehensive overview of the role and mechanism of immune regulation based on sex differences in ischemic stroke pathology.
Source: Frontiers in Immunology - January 30, 2023 Category: Allergy & Immunology Source Type: research

Astrocytes-derived exosomes pre-treated by berberine inhibit neuroinflammation after stroke via miR-182-5p/Rac1 pathway
CONCLUSION: BBR-exos can carry miR-182-5p to injured neurons and inhibit the expression of Rac1, which could inhibit neuroinflammation and improved brain injury after ischemic stroke.PMID:36996739 | DOI:10.1016/j.intimp.2023.110047
Source: International Immunopharmacology - March 30, 2023 Category: Allergy & Immunology Authors: Wangli Ding Qiuchen Gu Manman Liu Junqing Zou Jianguo Sun Junrong Zhu Source Type: research

Interferon- β modulates microglial polarization to ameliorate delayed tPA-exacerbated brain injury in ischemic stroke
In this study, we investigated the time limit of IFNβ treatment on the extension of tPA therapeutic window and assessed the effect of IFNβ on modulating microglia (MG) phenotypes in ischemic stroke with delayed tPA treatment. Mice were subjected to 40 minutes transient middle cerebral artery occlusion (MCAO) followed by delayed tPA treatment in the presence or absence of IFNβ at 3h, 4.5h or 6h post-reperfusion. In addition, mice with MG-specific IFNAR1 knockdown were generated to validate the effects of IFNβ on modulating MG phenotypes, ameliorating brain injury, and lessening BBB disruption in delayed tPA-treated MCAO...
Source: Frontiers in Immunology - April 1, 2023 Category: Allergy & Immunology Source Type: research

Astrocytes-derived exosomes pre-treated by berberine inhibit neuroinflammation after stroke via miR-182-5p/Rac1 pathway
CONCLUSION: BBR-exos can carry miR-182-5p to injured neurons and inhibit the expression of Rac1, which could inhibit neuroinflammation and improved brain injury after ischemic stroke.PMID:36996739 | DOI:10.1016/j.intimp.2023.110047
Source: International Immunopharmacology - March 30, 2023 Category: Allergy & Immunology Authors: Wangli Ding Qiuchen Gu Manman Liu Junqing Zou Jianguo Sun Junrong Zhu Source Type: research

Netrin-1 controls inflammation in response to ischemic stroke through altering microglia phenotype
ConclusionOur study highlights the potential of targeting Netrin-1 and its receptors as a promising therapeutic strategy for promoting post-ischemic survival and functional recovery.
Source: Frontiers in Immunology - June 14, 2023 Category: Allergy & Immunology Source Type: research

Increased Serum Levels of IL-1 β after Ischemic Stroke are Inversely Associated with Vitamin D
CONCLUSION: Ischemic stroke correlates positively with IL-1β and negatively with VitD levels. The speculated role of VitD deficiency in the evolution and severity of stroke may be justified by its role in the modification of inflammation.PMID:37431715 | DOI:10.22034/iji.2023.96384.2432
Source: Iranian Journal of Immunology - July 11, 2023 Category: Allergy & Immunology Authors: Mahnaz Bayat Niloufar Razavi Moosavi Najmeh Karimi Moosa Rahimi Afshin Borhani-Haghighi Source Type: research

Macrophage and monocyte subsets in response to ischemic stroke
This article is protected by copyright. All rights reserved.PMID:37467166 | DOI:10.1002/eji.202250233
Source: European Journal of Immunology - July 19, 2023 Category: Allergy & Immunology Authors: Nelli Blank-Stein Elvira Mass Source Type: research

Circulating Brain Derived Neurotrophic factor (BDNF) and frequency of BDNF positive T cells in peripheral blood in human ischemic stroke: Effect on outcome
The aim of this study was to measure the levels of circulating BDNF and the frequency of BDNF-producing T cells after acute ischaemic stroke. Serum BDNF levels were measured by ELISA. Flow cytometry was used to enumerate peripheral blood leukocytes that were labelled with antibodies against markers of T cells, T regulatory cells (Tregs), and intracellular BDNF. There was a slight increase in serum BDNF levels after stroke. There was no overall difference between stroke patients and controls in the frequency of CD4+ and CD8+ BDNF+ cells, although a subgroup of stroke patients showed high frequencies of these cells.
Source: Journal of Neuroimmunology - July 4, 2015 Category: Allergy & Immunology Authors: Adeline Chan, Jun Yan, Peter Csurhes, Judith Greer, Pamela McCombe Source Type: research

Antibodies to myelin basic protein are associated with cognitive decline after stroke
B lymphocytes cause post-stroke cognitive decline in mice. We therefore evaluated the association between autoantibodies and post-stroke cognitive decline in a prospectively collected human cohort. The mini-mental state exam (MMSE) was administered 30, 90, 180, and 365days after stroke. Antibody titers to myelin basic protein (MBP), proteolipid protein, and several non-specific proteins were determined. Among 58 subjects with initial MMSE≥20 and at least 2 MMSE examinations in the year after stroke, cognitive decline (MMSE decrease ≥2) occurred in 10 (17%) subjects.
Source: Journal of Neuroimmunology - April 7, 2016 Category: Allergy & Immunology Authors: Kyra J. Becker, Patricia Tanzi, Dannielle Zierath, Marion S. Buckwalter Source Type: research

The Possible Role of Toll-Like Receptor 4 in the Pathology of Stroke
This article reviews recent information regarding the impact of TLR4 on the pathogenicity of stroke.Neuroimmunomodulation
Source: Neuroimmunomodulation - June 8, 2016 Category: Allergy & Immunology Source Type: research

Atopic dermatitis is not independently associated with non‐fatal myocardial infarction or stroke among US women
This article is protected by copyright. All rights reserved.
Source: Allergy - May 31, 2016 Category: Allergy & Immunology Authors: Aaron M Drucker, Wen‐Qing Li, Eunyoung Cho, Tricia Li, Qi Sun, Carlos A Camargo, Abrar A Qureshi Tags: Brief Communication Source Type: research

Atopic dermatitis is not independently associated with nonfatal myocardial infarction or stroke among US women
Abstract We aimed to determine the association between atopic dermatitis (AD) and cardiovascular events in the Nurses' Health Study 2, a cohort of US women. We used logistic regression models to calculate age‐ and multivariate‐adjusted odds ratios (OR) and 95% confidence intervals (CI) for the associations between history of AD and nonfatal MI and nonfatal stroke. Of the 78 702 participants in our analysis, 7916 (10%) had a history of AD. There were 392 and 391 cases of nonfatal MI and stroke, respectively. AD was not associated with MI in age‐ or multivariate‐adjusted analyses. AD was significantly associated with...
Source: Allergy - July 19, 2016 Category: Allergy & Immunology Authors: A. M. Drucker, W.‐Q. Li, E. Cho, T. Li, Q. Sun, C. A. Camargo, A. A. Qureshi Tags: Brief Communication Source Type: research

The neuroprotection of Sinomenine against ischemic stroke in mice by suppressing NLRP3 inflammasome via AMPK signaling.
Abstract Neuroinflammation remains the primary cause of morbidity and mortality in stroke-induced secondary brain injury. The NOD-like receptor pyrin 3 (NLRP3) inflammasome is involved in diverse inflammatory diseases, including cerebral ischemia, and is thus considered an effective therapeutic target. In the present study, we investigated the neuroprotection of Sinomenine (SINO), a potent natural anti-apoptotic and anti-inflammatory molecule, against cerebral ischemia in a mouse model of middle cerebral artery occlusion (MCAO) in vivo and in an oxygen glucose deprivation (OGD)-treated astrocytes/microglia model i...
Source: International Immunopharmacology - October 17, 2016 Category: Allergy & Immunology Authors: Qiu J, Wang M, Zhang J, Cai Q, Lu D, Li Y, Dong Y, Zhao T, Chen H Tags: Int Immunopharmacol Source Type: research