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Specialty: Endocrinology
Condition: Pregnancy

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Total 23 results found since Jan 2013.

Relaxin peptide hormones are protective during the early stages of ischemic stroke in male rats.
Abstract The pregnancy hormone relaxin protects tissue from ischemic damage. The ability of relaxin-3, a relaxin paralog, to do so has not been explored. The cerebral expression of these peptides and their receptors make them logical targets for study in the ischemic brain. We assessed relaxin peptide-mediated protection, relative relaxin family peptide receptor (RXFP) involvement and protective mechanisms. Sprague-Dawley rats receiving permanent or transient middle cerebral artery occlusions (pMCAO and tMCAO, respectively), were treated with relaxin peptides and brains collected for infarct analysis. Activation o...
Source: Endocrinology - December 2, 2014 Category: Endocrinology Authors: Bergeron LH, Willcox JM, Alibhai FJ, Connell BJ, Saleh TM, Wilson BC, Summerlee AJ Tags: Endocrinology Source Type: research

Women who give birth after 40 'have higher risk of suffering a heart attack or stroke later in life'
A new report presented at the American Stroke Association's International Stroke Conference in LA states that women were more susceptible to stroke following late pregnancy. The Independent
Source: Society for Endocrinology - February 18, 2016 Category: Endocrinology Source Type: news

Exposure to maternal gestational diabetes is associated with higher cardiovascular responses to stress in adolescent Indians.
Conclusions: Maternal diabetes during pregnancy is associated with higher cardio-sympathetic stress-responses in the offspring, which may contribute to their higher cardiovascular disease risk. Further research may confirm stress-response programming as a predictor of cardiovascular risk in OGDM. PMID: 25478935 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - December 5, 2014 Category: Endocrinology Authors: Krishnaveni GV, Veena SR, Jones A, Srinivasan K, Osmond C, Karat SC, Kurpad AV, Fall CH Tags: J Clin Endocrinol Metab Source Type: research

Socioeconomic factors relating to diabetes and its management in India / 印度与糖尿病及其治疗相关的社会经济因素
Abstract Diabetes is an escalating problem in India and has major socioeconomic dimensions. Rapid dietary changes coupled with decreased levels of physical activity have resulted in increases in obesity and diabetes in rural and semi‐urban areas, as well as in urban‐based people living in resettlement colonies. Increasing risk has also been recorded in those who suffered from poor childhood nutrition and in rural‐to‐urban migrants. Social inequity manifests in disparities in socioeconomic status (SES), place of residence, education, gender, and level of awareness and affects prevention, care, and management. All th...
Source: Journal of Diabetes - July 30, 2015 Category: Endocrinology Authors: Usha Shrivastava, Anoop Misra, Rajeev Gupta, Vijay Viswanathan Tags: Review Article Source Type: research

Cardiovascular and renal burdens of prediabetes in the USA: analysis of data from serial cross-sectional surveys, 1988 –2014
Publication date: Available online 27 February 2018 Source:The Lancet Diabetes & Endocrinology Author(s): Mohammed K Ali, Kai McKeever Bullard, Sharon Saydah, Giuseppina Imperatore, Edward W Gregg Background There is controversy over the usefulness of prediabetes as a diagnostic label. Using data from US National Health and Nutrition Examination Surveys (NHANES) between 1988 and 2014, we examined the cardiovascular and renal burdens in adults with prediabetes over time and compared patterns with other glycaemic status groups. Methods We analysed cross-sectional survey data from non-pregnant adults aged 20 years an...
Source: The Lancet Diabetes and Endocrinology - February 28, 2018 Category: Endocrinology Source Type: research

Cardiovascular Programming During and After Diabetic Pregnancy: Role of Placental Dysfunction and IUGR
This study demonstrated that the incidence of ischemic heart disease and death were three times higher among men with low birth weight compared to men with high birth weight (5). Epidemiological investigations of adults born at the time of the Dutch famine between 1944 and 1945 revealed an association between maternal starvation and a low infant birth weight with a high incidence of hypertension and coronary heart disease in these adults (23). Furthermore, Painter et al. reported the incidence of early onset coronary heart disease among persons conceived during the Dutch famine (24). In that regard, Barker's findin...
Source: Frontiers in Endocrinology - April 8, 2019 Category: Endocrinology Source Type: research

Different effects of progesterone and estradiol on chimeric and wild type aldosterone synthase in vitro
Conclusions: Our results show an inhibitory action of progesterone in the aldosterone synthesis by chimeric or wild type aldosterone synthase enzymes. This is a novel regulatory mechanism of progesterone action, which could be involved in protecting pregnant women with FH-1 against hypertension. In vitro, both enzymes showed comparable kinetic parameters, but ASWT was more strongly inhibited than ASCE. This study implicates a new role for progesterone in the regulation of aldosterone levels that could contribute, along with other factors, to the maintenance of an adequate aldosterone-progesterone balance in pregnancy.
Source: Reproductive Biology and Endocrinology - August 13, 2013 Category: Endocrinology Authors: Andrea VecchiolaCarlos LagosCristóbal FuentesFidel AllendeCarmen CampinoCarolina ValdiviaAlejandra Tapia-CastilloTadashi OgishimaKuniaki MukaiGareth OwenSandra SolariCristian CarvajalCarlos Fardella Source Type: research

Socio‐Economic Factors Relating to Diabetes and its Management in India
Abstract Diabetes is an escalating problem in India and has major socio‐economic dimensions. Rapid dietary changes coupled with decreased level of physical activity have resulted in increasing obesity and diabetes in rural and semi‐urban areas and in urban based people living in resettlement colonies. Increasing risk has also been recorded in those who suffered from poor childhood nutrition, and in rural‐to‐urban migrants. Social inequity manifests in disparities in socio‐economic strata (SES), place of residence, education, gender, level of awareness and affect prevention, care and management. All these populati...
Source: Journal of Diabetes - May 28, 2015 Category: Endocrinology Authors: Usha Shrivastava, Anoop Misra, Rajeev Gupta, Vijay Viswanathan Tags: Review Article Source Type: research

Socioeconomic factors relating to diabetes and its management in India
Abstract Diabetes is an escalating problem in India and has major socioeconomic dimensions. Rapid dietary changes coupled with decreased levels of physical activity have resulted in increases in obesity and diabetes in rural and semi‐urban areas, as well as in urban‐based people living in resettlement colonies. Increasing risk has also been recorded in those who suffered from poor childhood nutrition and in rural‐to‐urban migrants. Social inequity manifests in disparities in socioeconomic status (SES), place of residence, education, gender, and level of awareness and affects prevention, care, and management. All th...
Source: Journal of Diabetes - July 30, 2015 Category: Endocrinology Authors: Usha Shrivastava, Anoop Misra, Rajeev Gupta, Vijay Viswanathan Tags: Review Article Source Type: research

Chronic kidney disease among US adults with type 2 diabetes and cardiovascular diseases: A national estimate of prevalence by KDIGO 2012 classification
ConclusionsThis study confirms the high prevalence of CKD in patients with multiple comorbidities: T2D and CVD. It also provides estimates of the prevalence of CKD categories based on KDIGO 2012 classification for US adults with T2D.
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - November 3, 2018 Category: Endocrinology Source Type: research

The long and short term effects of motherhood on the brain.
Abstract Becoming a mother is associated with dramatic changes in physiology, endocrinology, immune function, and behaviour that begins during pregnancy and persists into the postpartum. Evidence also suggests that motherhood is accompanied with long-term changes in brain function. In this review, we summarize the short (pregnancy and postpartum) and long-term (beyond the postpartum and into middle age) effects of pregnancy and motherhood on cognition, neuroplasticity, and neuroimmune signalling. We also discuss the effects of previous history of pregnancy and motherhood (parity) on brain health and disease (neuro...
Source: Frontiers in Neuroendocrinology - February 27, 2019 Category: Endocrinology Authors: Duarte-Guterman P, Leuner B, Galea LAM Tags: Front Neuroendocrinol Source Type: research

Glucose screening in pregnancy and future risk of cardiovascular disease in women: a retrospective, population-based cohort study
Publication date: Available online 27 March 2019Source: The Lancet Diabetes & EndocrinologyAuthor(s): Ravi Retnakaran, Baiju R ShahSummaryBackgroundIn studies to date, gestational diabetes has consistently been associated with an increased future risk of cardiovascular disease, irrespective of the antepartum screening protocol or diagnostic criteria by which gestational diabetes is diagnosed. We reasoned that the resultant heterogeneity in the severity of dysglycaemia in women with gestational diabetes suggests that the relationship between gestational glycaemia and subsequent cardiovascular disease probably extends into t...
Source: The Lancet Diabetes and Endocrinology - March 28, 2019 Category: Endocrinology Source Type: research

Hypothalamic impairment underlying heat intolerance in pregnant mice
In conclusion, pregnancy induces heat intolerance by inducing hypothalamic impairment in mice. Additionally, HBO2T protects against heat intolerance in pregnant mice by preserving hypothalamic integrity.
Source: Molecular and Cellular Endocrinology - May 6, 2019 Category: Endocrinology Source Type: research

REVIEW: Obesity, neuroinflammation and reproductive function.
Abstract The increasing occurrence of obesity has become a significant public health concern. Obese individuals have higher prevalence of heart disease, stroke, osteoarthritis, diabetes, and reproductive disorders. Reproductive problems include menstrual irregularities, pregnancy complications, and infertility due to anovulation, in women, and lower testosterone and diminished sperm count, in men. In particular, obese women have reduced levels of both gonadotropin hormones and, in obese men, lower testosterone is accompanied by diminished luteinizing hormone. Together these findings indicate central dysregulation ...
Source: Endocrinology - September 11, 2019 Category: Endocrinology Authors: Lainez NM, Coss D Tags: Endocrinology Source Type: research

Pregnancy, Postpartum and Parity: Resilience and Vulnerability in Brain Health and Disease.
Abstract Risk and resilience in brain health and disease can be influenced by a variety of factors. While there is a growing appreciation to consider sex as one of these factors, far less attention has been paid to sex-specific variables that may differentially impact females such as pregnancy and reproductive history. In this review, we focus on nervous system disorders which show a female bias and for which there is data from basic research and clinical studies pointing to modification in disease risk and progression during pregnancy, postpartum and/or as a result of parity: multiple sclerosis (MS), depression, ...
Source: Frontiers in Neuroendocrinology - January 23, 2020 Category: Endocrinology Authors: Deems N, Leuner B Tags: Front Neuroendocrinol Source Type: research