Cardiovascular and renal burdens of prediabetes in the USA: analysis of data from serial cross-sectional surveys, 1988 –2014

Publication date: Available online 27 February 2018 Source:The Lancet Diabetes & Endocrinology Author(s): Mohammed K Ali, Kai McKeever Bullard, Sharon Saydah, Giuseppina Imperatore, Edward W Gregg Background There is controversy over the usefulness of prediabetes as a diagnostic label. Using data from US National Health and Nutrition Examination Surveys (NHANES) between 1988 and 2014, we examined the cardiovascular and renal burdens in adults with prediabetes over time and compared patterns with other glycaemic status groups. Methods We analysed cross-sectional survey data from non-pregnant adults aged 20 years and older from the NHANES survey periods 1988–94, 1999–2004, 2005–10, and 2011–14. We defined diagnosed diabetes as patients' self-report that they had been previously diagnosed by a physician or health professional; among those with no self-reported diabetes, prediabetes was defined as a fasting plasma glucose (FPG) concentration of 100–125 mg/dL (5·6–6·9 mmol/L) or an HbA1c of 5·7–6·4% (39–47 mmol/mol); undiagnosed diabetes as an FPG of 126 mg/dL (7·0 mmol/L) or higher or an HbA1c of 6·5% (48 mmol/mol) or higher; and normal glycaemic status as an FPG of less than 100 mg/dL (5·6 mmol/L) and an HbA1c of less than 5·7% (39 mmol/mol). We repeated the analyses using varying definitions of prediabetes (FPG 110–125 mg/dL [6·1–6·9 mmol/L] or HbA1c 5·7–6·4% [39–47 mmol/mol], FPG 110–125 mg/dL [6·1–6·9 mmol/L] or HbA1c ...
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research