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Nutrition: Manganese

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Total 38 results found since Jan 2013.

Brain-Derived Neurotrophic Factor Levels are Lower in Chronic Stroke Patients: A Relation with Manganese-dependent Superoxide Dismutase ALA16VAL Single Nucleotide Polymorphism through Tumor Necrosis Factor- α and Caspases Pathways
The manganese-dependent superoxide dismutase (MnSOD) Ala16Val single nucleotide polymorphism (SNP) has shown to be associated to risk factors of vascular diseases. Brain-Derived Neurotrophic Factor (BDNF) plays an essential role in the plasticity and neuronal regeneration of the brain after vascular injuries. However, little is known about interaction between MnSOD Ala16Val SNP on stroke, a frequent neurologic disease that involves various interacting pathways, such as vascular dysfunctions, inflammation, and neurotrophic factors.
Source: Journal of Stroke and Cerebrovascular Diseases - August 25, 2018 Category: Neurology Authors: Mr. Eduardo Tanuri Pascotini, Dr. Ariane Ethur Flores, Mrs. Aline Kegler, Mrs. Vivana Konzen, Mrs. Ana Let ícia Fornari, Mrs. Josi Arend, Mrs. Patricia Gabbi, Mrs. Luciana Assis Gobo, Dr. Guilherme Vargas Bochi, Dr. Ana Lucia Cervi Prado, Dr. Leandro Mac Source Type: research

Differential associations of particle size ranges and constituents with stroke emergency-room visits in Shanghai, China
CONCLUSION: Ultra-fine particles and some PM2.5 constituents (i.e., carbonaceous fractions, inorganic ions and some elements) may be mainly responsible for the excess risk of stroke induced by PM2.5.PMID:35104777 | DOI:10.1016/j.ecoenv.2022.113237
Source: Ecotoxicology and Environmental Safety - February 1, 2022 Category: Environmental Health Authors: Yuhao Zhang Qinglin He Yaping Zhang Xiaowei Xue Haidong Kan Xin Wang Source Type: research

Arsenic, polycyclic aromatic hydrocarbons, and metal exposure and risk assessment of stroke
This study aimed to assess different arsenic species, including total arsenic; two types of organic arsenic, i.e., arsenobetaine and arsenocholine; four types of inorganic arsenic, i.e., arsenic acid, arsenous acid, dimethylarsinic acid (DMA), and monomethylarsonic acid (MMA); six types of urinary polycyclic aromatic hydrocarbon (PAH) compounds, i.e., 1-hydroxynaphthalene, 1-hydroxyphenanthrene, 1-hydroxypyrene, 2-hydroxynaphthalene, 2-hydroxyfluorene, and 3-hydroxyfluorene; and fourteen types of metals from urine specimen, i.e., manganese, cadmium, lead, mercury, barium, cobalt, strontium, molybdenum, cesium, thallium, an...
Source: Environmental Science and Pollution Research International - July 6, 2023 Category: Environmental Health Authors: Humairat H Rahman Sifat Parveen Sheikh Stuart H Munson-McGee Source Type: research

A Bioinspired Manganese-Organic Framework Ameliorates Ischemic Stroke through its Intrinsic Nanozyme Activity and Upregulating Endogenous Antioxidant Enzymes
Adv Sci (Weinh). 2023 May 2:e2206854. doi: 10.1002/advs.202206854. Online ahead of print.ABSTRACTFollowing stroke, oxidative stress induced by reactive oxygen species (ROS) aggravates neuronal damage and enlarges ischemic penumbra, which is devastating to stroke patients. Nanozyme-based antioxidants are emerging to treat stroke through scavenging excessive ROS. However, most of nanozymes cannot efficiently scavenge ROS in neuronal cytosol and mitochondria, due to low-uptake abilities of neurons and barriers of organelle membranes, significantly limiting nanozymes' neuroprotective effects. To overcome this limitation, a man...
Source: Adv Data - May 2, 2023 Category: Epidemiology Authors: Jian Wang Yang Wang Xiakeerzhati Xiaohalati Qiangfei Su Jingwei Liu Bo Cai Wen Yang Zheng Wang Lin Wang Source Type: research

Lauric acid provides neuroprotection against oxidative stress in mouse model of hyperglycaemic stroke
Eur J Pharmacol. 2023 Aug 10:175990. doi: 10.1016/j.ejphar.2023.175990. Online ahead of print.ABSTRACTDuring ischemic stroke, higher glucose level linked worse outcomes were reported even in patients without pre-existing diabetes. Evidence suggest that such worse stroke outcomes were mainly due to production of reactive, toxic glucose metabolites that expands oxidative damage inside the brain. As a consequence of high oxidative stress, microvasculature structures and tight junctions compromised their functionally, infarct volume expands and brain edema exacerbates. In a mouse model of ischemic stroke with induced acute hyp...
Source: European Journal of Pharmacology - August 12, 2023 Category: Drugs & Pharmacology Authors: Zaib Ali Shaheryar Mahtab Ahmad Khan Huma Hameed Syed Awais Ali Zaidi Irfan Anjum Muhammad Shafeeq Ur Rahman Source Type: research

Associations of multiple plasma metals with the risk of ischemic stroke: A case-control study.
CONCLUSIONS: Our study suggested that higher plasma concentrations of aluminum, arsenic, and cadmium, and lower concentrations of iron and selenium may increase the risk of IS. Further prospective studies in larger populations are warranted to confirm our findings. PMID: 30716572 [PubMed - as supplied by publisher]
Source: Environment International - February 1, 2019 Category: Environmental Health Authors: Wen Y, Huang S, Zhang Y, Zhang H, Zhou L, Li D, Xie C, Lv Z, Guo Y, Ke Y, Wu T, Cheng J Tags: Environ Int Source Type: research

MnCO < sub > 3 < /sub > @BSA-ICG nanoparticles as a magnetic resonance/photoacoustic dual-modal contrast agent for functional imaging of acute ischemic stroke
Biochem Biophys Res Commun. 2022 May 5;614:125-131. doi: 10.1016/j.bbrc.2022.04.143. Online ahead of print.ABSTRACTTimely and accurate diagnosis of acute ischemic stroke (AIS) and simultaneous functional imaging of cerebral oxygen saturation (sO2) are essential to improve the survival rate of stroke patients but remains challenging. Herein, we developed a pH-responsive manganese (Mn)-based nanoplatform as a magnetic resonance/photoacoustic (MR/PA) dual-modal contrast agent for AIS diagnosis. The Mn-based nanoplatform was prepared via a simple and green biomimetic method using bovine serum albumin (BSA) as a scaffold for fa...
Source: Biochemical and Biophysical Research communications - May 17, 2022 Category: Biochemistry Authors: Guangrong Song Baorui Zhang Linyan Song Wenzhe Li Chuxuan Liu Leshan Chen Aihua Liu Source Type: research

Metal cation controls phosphate release in the myosin ATPase
This article is protected by copyright. All rights reserved.
Source: Protein Science - August 10, 2017 Category: Biochemistry Authors: Jinghua Ge, Furong Huang, Yuri E. Nesmelov Tags: Full ‐Length Papers Source Type: research

Association of blood manganese level with diabetes and renal dysfunction: a cross-sectional study of the Korean general population
Conclusion: The prevalence of diabetes and renal dysfunction increased in participants with low blood manganese levels, suggesting that blood manganese may play a role in glucose homeostasis and renal function.
Source: BMC Endocrine Disorders - March 8, 2014 Category: Endocrinology Authors: Eun Sil KohSung Jun KimHye Eun YoonJong Hee ChungSungjin ChungCheol Whee ParkYoon Sik ChangSeok Joon Shin Source Type: research

Plasma Metal Concentrations and Incident Coronary Heart Disease in Chinese Adults: The Dongfeng-Tongji Cohort
Conclusions: Our study suggested that incident CHD was positively associated with plasma levels of titanium and arsenic, and inversely associated with selenium. Additional research is needed to confirm these findings in other populations. https://doi.org/10.1289/EHP1521 Received: 22 December 2016 Revised: 17 September 2017 Accepted: 19 September 2017 Published: 19 October 2017 Address correspondence to T. Wu, or A. Pan, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hongkong Rd., Wuhan 430030, Hubei, China. Telephone: +86-27-83692347. Email: wut@mails.tjmu.edu.cn or p...
Source: EHP Research - October 20, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research