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Nutrition: Manganese

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Total 38 results found since Jan 2013.

Lauric acid provides neuroprotection against oxidative stress in mouse model of hyperglycaemic stroke
Eur J Pharmacol. 2023 Aug 10:175990. doi: 10.1016/j.ejphar.2023.175990. Online ahead of print.ABSTRACTDuring ischemic stroke, higher glucose level linked worse outcomes were reported even in patients without pre-existing diabetes. Evidence suggest that such worse stroke outcomes were mainly due to production of reactive, toxic glucose metabolites that expands oxidative damage inside the brain. As a consequence of high oxidative stress, microvasculature structures and tight junctions compromised their functionally, infarct volume expands and brain edema exacerbates. In a mouse model of ischemic stroke with induced acute hyp...
Source: European Journal of Pharmacology - August 12, 2023 Category: Drugs & Pharmacology Authors: Zaib Ali Shaheryar Mahtab Ahmad Khan Huma Hameed Syed Awais Ali Zaidi Irfan Anjum Muhammad Shafeeq Ur Rahman Source Type: research

Arsenic, polycyclic aromatic hydrocarbons, and metal exposure and risk assessment of stroke
This study aimed to assess different arsenic species, including total arsenic; two types of organic arsenic, i.e., arsenobetaine and arsenocholine; four types of inorganic arsenic, i.e., arsenic acid, arsenous acid, dimethylarsinic acid (DMA), and monomethylarsonic acid (MMA); six types of urinary polycyclic aromatic hydrocarbon (PAH) compounds, i.e., 1-hydroxynaphthalene, 1-hydroxyphenanthrene, 1-hydroxypyrene, 2-hydroxynaphthalene, 2-hydroxyfluorene, and 3-hydroxyfluorene; and fourteen types of metals from urine specimen, i.e., manganese, cadmium, lead, mercury, barium, cobalt, strontium, molybdenum, cesium, thallium, an...
Source: Environmental Science and Pollution Research International - July 6, 2023 Category: Environmental Health Authors: Humairat H Rahman Sifat Parveen Sheikh Stuart H Munson-McGee Source Type: research

Stratification of US adults based on exposure to lead, cadmium, manganese, and mercury and their effects on cardiovascular diseases
ConclusionsExposure to high levels of metal mixtures may be a potential predictor of CVDs. Unsupervised clustering method-based stratification of the population using metal mixtures provides a reliable and promising method for the analysis of the relationship between metal mixtures and health endpoints.
Source: Journal of Public Health - June 22, 2023 Category: Health Management Source Type: research

A Bioinspired Manganese-Organic Framework Ameliorates Ischemic Stroke through its Intrinsic Nanozyme Activity and Upregulating Endogenous Antioxidant Enzymes
Adv Sci (Weinh). 2023 May 2:e2206854. doi: 10.1002/advs.202206854. Online ahead of print.ABSTRACTFollowing stroke, oxidative stress induced by reactive oxygen species (ROS) aggravates neuronal damage and enlarges ischemic penumbra, which is devastating to stroke patients. Nanozyme-based antioxidants are emerging to treat stroke through scavenging excessive ROS. However, most of nanozymes cannot efficiently scavenge ROS in neuronal cytosol and mitochondria, due to low-uptake abilities of neurons and barriers of organelle membranes, significantly limiting nanozymes' neuroprotective effects. To overcome this limitation, a man...
Source: Adv Data - May 2, 2023 Category: Epidemiology Authors: Jian Wang Yang Wang Xiakeerzhati Xiaohalati Qiangfei Su Jingwei Liu Bo Cai Wen Yang Zheng Wang Lin Wang Source Type: research

Adoption of Manganese-Doped Copper Sulfide Nanodot-Based Multimodal Magnetic Resonance Imaging in Prognosis Prediction of Patients with Ischemic Stroke Under Nutritional Care
Source: Journal of Biomedical Nanotechnology - October 21, 2022 Category: Nanotechnology Authors: Wei, Ying Zhang, Junqin Tags: research-article Source Type: research

Preconditioning exercise reduces hippocampal neuronal damage via increasing Klotho expression in ischemic rats
In this study, we assessed neuroprotective effects of preconditioning exercise in rats (treadmill running at a speed of 20m/min,30min/day, six days/week, for3 weeks) on hippocampal Klotho and MnSOD expression in the brain using an animal model of stroke, middle cerebral artery occlusion (MCAO). Our study revealed a reduction in hippocampal Klotho and MnSOD expression as well as CA1 neuronal activity in MCAO compared to the sham group. Exercise prevented the ischemia-induced decline in Klotho and MnSOD expression levels as well as CA1 neuronal activity in Exercise + MCAO compared to the MCAO group. Also, exercise significan...
Source: Brain Research Bulletin - August 2, 2022 Category: Neurology Authors: Maryam Soleimani Karizmeh Maryam Shabani Mostafa Shabani Maryam Sardari Javad Fahanik Babaei Fatemeh Nabavizadeh Seyed Shahabeddin Sadr Soheila Adeli Source Type: research

MnCO < sub > 3 < /sub > @BSA-ICG nanoparticles as a magnetic resonance/photoacoustic dual-modal contrast agent for functional imaging of acute ischemic stroke
Biochem Biophys Res Commun. 2022 May 5;614:125-131. doi: 10.1016/j.bbrc.2022.04.143. Online ahead of print.ABSTRACTTimely and accurate diagnosis of acute ischemic stroke (AIS) and simultaneous functional imaging of cerebral oxygen saturation (sO2) are essential to improve the survival rate of stroke patients but remains challenging. Herein, we developed a pH-responsive manganese (Mn)-based nanoplatform as a magnetic resonance/photoacoustic (MR/PA) dual-modal contrast agent for AIS diagnosis. The Mn-based nanoplatform was prepared via a simple and green biomimetic method using bovine serum albumin (BSA) as a scaffold for fa...
Source: Biochemical and Biophysical Research communications - May 17, 2022 Category: Biochemistry Authors: Guangrong Song Baorui Zhang Linyan Song Wenzhe Li Chuxuan Liu Leshan Chen Aihua Liu Source Type: research