Brain-Derived Neurotrophic Factor Levels are Lower in Chronic Stroke Patients: A Relation with Manganese-dependent Superoxide Dismutase ALA16VAL Single Nucleotide Polymorphism through Tumor Necrosis Factor- α and Caspases Pathways

The manganese-dependent superoxide dismutase (MnSOD) Ala16Val single nucleotide polymorphism (SNP) has shown to be associated to risk factors of vascular diseases. Brain-Derived Neurotrophic Factor (BDNF) plays an essential role in the plasticity and neuronal regeneration of the brain after vascular injuries. However, little is known about interaction between MnSOD Ala16Val SNP on stroke, a frequent neurologic disease that involves various interacting pathways, such as vascular dysfunctions, inflammation, and neurotrophic factors.

Source: Journal of Stroke and Cerebrovascular Diseases - August 25, 2018 Category: Neurology Authors: Mr. Eduardo Tanuri Pascotini, Dr. Ariane Ethur Flores, Mrs. Aline Kegler, Mrs. Vivana Konzen, Mrs. Ana Let ícia Fornari, Mrs. Josi Arend, Mrs. Patricia Gabbi, Mrs. Luciana Assis Gobo, Dr. Guilherme Vargas Bochi, Dr. Ana Lucia Cervi Prado, Dr. Leandro Mac Source Type: research