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Total 78 results found since Jan 2013.

Non-Vitamin K Oral Anticoagulants for Stroke Prevention in Special Populations with Atrial Fibrillation
AbstractAtrial fibrillation (AF) is associated with an increased risk of ischemic stroke or systemic embolism compared with normal sinus rhythm. These strokes may efficiently be prevented in patients with risk factors using oral anticoagulant therapy, with either vitamin K antagonists (VKAs) or non-vitamin K antagonist oral anticoagulants (NOACs) (i.e., direct thrombin inhibitors or direct factor Xa inhibitors). Owing to their specific risk profiles, some AF populations may have increased risks of both thromboembolic and bleeding events. These AF patients may be denied oral anticoagulants, whilst evidence shows that the ab...
Source: Advances in Therapy - May 10, 2017 Category: Drugs & Pharmacology Source Type: research

Predicting 1-Hour Thrombolysis Effect of r-tPA in Patients With Acute Ischemic Stroke Using Machine Learning Algorithm
Conclusion: This study demonstrated that the GBDT model with the seven variables could better predict the early thrombolysis effect of r-tPA.
Source: Frontiers in Pharmacology - January 3, 2022 Category: Drugs & Pharmacology Source Type: research

Total saponins from Trillium tschonoskii Maxim promote neurological recovery in model rats with post-stroke cognitive impairment
Total saponins from Trillium tschonoskii Maxim (TSTT), a bioactive component of local natural herbs in the Enshi area, China, have been demonstrated to have functions of restoring cognitive capacity and promoting axonal regeneration post-stroke, but the mechanism of this process remains unclear. The hippocampus is a critical tissue for controlling learning and memory capacity, and the sonic hedgehog (Shh) signaling pathway plays a major role in the patterning and synaptic plasticity of hippocampal neural circuits. Therefore, we aimed to investigate whether TSTT could restore learning and cognitive functions by modulating t...
Source: Frontiers in Pharmacology - September 7, 2023 Category: Drugs & Pharmacology Source Type: research

What can we learn about stroke from retinal ischemia models?
Abstract Retinal ischemia is a very useful model to study the impact of various cell death pathways, such as apoptosis and necrosis, in the ischemic retina. However, it is important to note that the retina is formed as an outpouching of the diencephalon and is part of the central nervous system. As such, the cell death pathways initiated in response to ischemic damage in the retina reflect those found in other areas of the central nervous system undergoing similar trauma. The retina is also more accessible than other areas of the central nervous system, thus making it a simpler model to work with and study. By uti...
Source: Acta Pharmacologica Sinica - January 1, 2013 Category: Drugs & Pharmacology Authors: D'Onofrio PM, Koeberle PD Tags: Acta Pharmacol Sin Source Type: research

RPS Wales calls for pharmacists to raise awareness of mini stroke
The Royal Pharmaceutical Society in Wales (RPS Wales) is calling for pharmacists to use their skills to educate patients on the risks factors that can cause a stroke and to help patients with these risks to learn the early warning signs so they can act and act fast.   T
Source: Royal Pharmaceutical Society News - April 30, 2014 Category: Drugs & Pharmacology Source Type: news

DL-3-n-butylphthalide (NBP) alleviates poststroke cognitive impairment (PSCI) by suppressing neuroinflammation and oxidative stress
In this study, we aimed to investigate the influences of NBP on cognitive function in an ischemic reperfusion (I/R) rat model. Our results showed that NBP profoundly decreased neurological scores, reduced cerebral infarct areas and enhanced cerebral blood flow (CBF). NBP potently alleviated poststroke cognitive impairment (PSCI) including depression-like behavior and learning, memory and social cognition impairments, in I/R rats. NBP distinctly suppressed the activation of microglia and astrocytes and improved neuron viability in the ischemic brain. NBP inhibited the expression of inflammatory cytokines, including interleu...
Source: Frontiers in Pharmacology - January 11, 2023 Category: Drugs & Pharmacology Source Type: research

Effects of IL-1 β on hippocampus cell apoptosis and learning ability of vascular dementia rats.
CONCLUSIONS: IL-1β can delay VD occurrence and development through the P38-MAPK signaling pathway to regulate cell apoptosis and improve learning ability. PMID: 30280789 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - October 5, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

A molecular view of the function and pharmacology of acid-sensing ion channels
Publication date: Available online 5 February 2019Source: Pharmacological ResearchAuthor(s): Sabrina Vullo, Stephan KellenbergerAbstractThe pH in the different tissues and organs of our body is kept within tight limits. Local pH changes occur, however, temporarily under physiological conditions, as for example in synapses during neuronal activity. In pathological situations, such as in ischemia, inflammation, and tumor growth, long-lasting acidification develops. Acid-sensing ion channels (ASICs) are low pH-activated Na+-permeable ion channels that are widely expressed in the central and peripheral nervous systems. ASICs a...
Source: Pharmacological Research - February 5, 2019 Category: Drugs & Pharmacology Source Type: research

Preventable Cases of Oral Anticoagulant-Induced Bleeding: Data From the Spontaneous Reporting System
Conclusion: Our findings describe the most reported risk factors for preventability of oral anticoagulant-induced bleedings. These factors may be useful for targeting interventions to improve pharmacovigilance activities in our regional territory and to reduce the burden of medication errors and inappropriate prescription. Introduction Oral anticoagulant therapy is widely used for the prevention of stroke and systemic embolism in patients with atrial fibrillation, or for the prevention and treatment of deep vein thrombosis and pulmonary embolism (Raj et al., 1994; Monaco et al., 2017). Oral anticoagulants can be di...
Source: Frontiers in Pharmacology - April 29, 2019 Category: Drugs & Pharmacology Source Type: research

Effects of cordycepin on Y-maze learning task in mice.
In this study, simultaneously, we found that administrated orally cordycepin significantly decreased the neuronal loss induced by ischemia in hippocampal CA1 and CA3 regions. Collectively, our results can provide valuable evidence that cordycepin may act as a nootropic product or potential clinical application in improving cognitive function of patients with ischemic stroke in the future. PMID: 23819912 [PubMed - as supplied by publisher]
Source: European Journal of Pharmacology - June 29, 2013 Category: Drugs & Pharmacology Authors: Cai ZL, Wang CY, Jiang ZJ, Li HH, Liu WX, Gong LW, Xiao P, Li CH Tags: Eur J Pharmacol Source Type: research

Potassium 2-(1-hydroxypentyl)-benzoate promotes long-term potentiation in Aβ1-42-injected rats and APP/PS1 transgenic mice.
Conclusion:Chronic administration of dl-PHPB improves learning and memory and promotes LTP in the animal models of Alzheimer's disease, possibly via increasing p-GluN2B expression in the hippocampus. PMID: 24858312 [PubMed - as supplied by publisher]
Source: Acta Pharmacologica Sinica - May 26, 2014 Category: Drugs & Pharmacology Authors: Li PP, Wang WP, Liu ZH, Xu SF, Lu WW, Wang L, Wang XL Tags: Acta Pharmacol Sin Source Type: research

Rare platelet G protein‐coupled receptor variants: What Can We Learn?
Summary Platelet expressed G protein‐coupled receptors (GPCRs) are critical regulators of platelet function. Pharmacological blockade of these receptors forms a powerful therapeutic tool in the treatment and prevention of arterial thrombosis associated with coronary atherosclerosis and ischaemic stroke. However, anti‐thrombotic drug therapy is associated with high inter‐patient variability in therapeutic response and adverse bleeding side‐effects. In order to optimise the use of existing antiplatelet drugs and to develop new therapies more detailed knowledge is required relating to the molecular mechanisms that reg...
Source: British Journal of Pharmacology - September 18, 2014 Category: Drugs & Pharmacology Authors: S. P. Nisar, M L Jones, M R Cunningham, A D Mumford, S J Mundell, Tags: Review Article – 5th BPS Focused Meeting on Cell Signalling Themed Issue Source Type: research

Rare platelet GPCR variants: what can we learn?
Platelet‐expressed GPCRs are critical regulators of platelet function. Pharmacological blockade of these receptors forms a powerful therapeutic tool in the treatment and prevention of arterial thrombosis associated with coronary atherosclerosis and ischaemic stroke. However, anti‐thrombotic drug therapy is associated with high inter‐patient variability in therapeutic response and adverse bleeding side effects. In order to optimize the use of existing anti‐platelet drugs and to develop new therapies, more detailed knowledge is required relating to the molecular mechanisms that regulate GPCR and therefore platelet fu...
Source: British Journal of Pharmacology - November 24, 2014 Category: Drugs & Pharmacology Authors: S P Nisar, M L Jones, M R Cunningham, A D Mumford, S J Mundell, Tags: REVIEW ARTICLE THEMED ISSUE Source Type: research

The Effects of Sigma‐1 Receptor Selective Ligands on Muscarinic Receptor Antagonist Induced Cognitive Deficits in Mice
Conclusions and ImplicationsThe sigma‐1 receptor selective compound such as LS‐1‐137 may represent a novel candidate cognitive enhancer for the treatment of cholinergic muscarinic‐dependent cognitive deficits.
Source: British Journal of Pharmacology - January 9, 2015 Category: Drugs & Pharmacology Authors: Maninder Malik, Claudia Rangel‐Barajas, Nathalie Sumien, Chang Su, Meharvan Singh, Zhenglan Chen, Ren‐Qi Huang, Johann Meunier, Tangui Maurice, Robert H. Mach, Robert R. Luedtke Tags: Research Paper Source Type: research

The Effect of Acori graminei Rhizoma and Extract Fractions on Spatial Memory and Hippocampal Neurogenesis in Amyloid Beta 1-42 Injected Mice.
This study aimed to investigate the neuroprotective effects of different extract fractions from AGR against Alzheimer disease-like symptoms induced by Amyloid Beta (Aß) 1-42 intra-hippocampal injection. On day 7 after intra-hippocampal injection of saline or Aβ1-42, spatial memory was assessed by the first Morris water maze, followed by 3-week intra-gastric administration of saline or water extract, volatile oil fraction, or defatted decoction fraction of AGR respectively. Mice were subsequently subjected to the second Morris water maze task. Levels of Aβ1-42 and expressions of doublecortin and nestin in the hippocampus...
Source: CNS and Neurological Disorders Drug Targets - February 25, 2015 Category: Drugs & Pharmacology Authors: Ma Y, Tian S, Sun L, Yao S, Liang Z, Li S, Liu J, Zang L, Li G Tags: CNS Neurol Disord Drug Targets Source Type: research