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Specialty: Drugs & Pharmacology
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Total 78 results found since Jan 2013.
Functional crosstalk of the glycine transporter GlyT1 and NMDA receptors
Neuropharmacology. 2023 Mar 30:109514. doi: 10.1016/j.neuropharm.2023.109514. Online ahead of print.ABSTRACTNMDA-type glutamate receptors (NMDARs) constitute one of the main glutamate (Glu) targets in the central nervous system and are involved in synaptic plasticity, which is the molecular substrate of learning and memory. Hypofunction of NMDARs has been associated with schizophrenia, while overstimulation causes neuronal death in neurodegenerative diseases or in stroke. The function of NMDARs requires coincidental binding of Glu along with other cellular signals such as neuronal depolarization, and the presence of other ...
Source: Neuropharmacology - April 1, 2023 Category: Drugs & Pharmacology Authors: Dolores Piniella Francisco Zafra Source Type: research
Bryostatin-1: a promising compound for neurological disorders
The central nervous system (CNS) is the most complex system in human body, and there is often a lack of effective treatment strategies for the disorders related with CNS. Natural compounds with multiple pharmacological activities may offer better options because they have broad cellular targets and potentially produce synergic and integrative effects. Bryostatin-1 is one of such promising compounds, a macrolide separated from marine invertebrates. Bryostatin-1 has been shown to produce various biological activities through binding with protein kinase C (PKC). In this review, we mainly summarize the pharmacological effects ...
Source: Frontiers in Pharmacology - June 7, 2023 Category: Drugs & Pharmacology Source Type: research
