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Total 78 results found since Jan 2013.
Total saponins from Trillium tschonoskii Maxim promote neurological recovery in model rats with post-stroke cognitive impairment
Total saponins from Trillium tschonoskii Maxim (TSTT), a bioactive component of local natural herbs in the Enshi area, China, have been demonstrated to have functions of restoring cognitive capacity and promoting axonal regeneration post-stroke, but the mechanism of this process remains unclear. The hippocampus is a critical tissue for controlling learning and memory capacity, and the sonic hedgehog (Shh) signaling pathway plays a major role in the patterning and synaptic plasticity of hippocampal neural circuits. Therefore, we aimed to investigate whether TSTT could restore learning and cognitive functions by modulating t...
Source: Frontiers in Pharmacology - September 7, 2023 Category: Drugs & Pharmacology Source Type: research
Bryostatin-1: a promising compound for neurological disorders
The central nervous system (CNS) is the most complex system in human body, and there is often a lack of effective treatment strategies for the disorders related with CNS. Natural compounds with multiple pharmacological activities may offer better options because they have broad cellular targets and potentially produce synergic and integrative effects. Bryostatin-1 is one of such promising compounds, a macrolide separated from marine invertebrates. Bryostatin-1 has been shown to produce various biological activities through binding with protein kinase C (PKC). In this review, we mainly summarize the pharmacological effects ...
Source: Frontiers in Pharmacology - June 7, 2023 Category: Drugs & Pharmacology Source Type: research
Functional crosstalk of the glycine transporter GlyT1 and NMDA receptors
Neuropharmacology. 2023 Mar 30:109514. doi: 10.1016/j.neuropharm.2023.109514. Online ahead of print.ABSTRACTNMDA-type glutamate receptors (NMDARs) constitute one of the main glutamate (Glu) targets in the central nervous system and are involved in synaptic plasticity, which is the molecular substrate of learning and memory. Hypofunction of NMDARs has been associated with schizophrenia, while overstimulation causes neuronal death in neurodegenerative diseases or in stroke. The function of NMDARs requires coincidental binding of Glu along with other cellular signals such as neuronal depolarization, and the presence of other ...
Source: Neuropharmacology - April 1, 2023 Category: Drugs & Pharmacology Authors: Dolores Piniella Francisco Zafra Source Type: research
Ginkgo biloba extract EGb 761 ® improves cognition and overall condition after ischemic stroke: Results from a pilot randomized trial
Conclusion: Over the 24-week period, EGb 761® treatment improved overall cognitive performance among patients with mild to moderate ischemic stroke. Our findings provide valuable recommendations for the design of future trials, including the criteria for patient selection.Clinical Trial Registration:www.isrctn.com, identifier ISRCTN11815543.
Source: Frontiers in Pharmacology - March 29, 2023 Category: Drugs & Pharmacology Source Type: research
Acori Tatarinowii Rhizoma: A comprehensive review of its chemical composition, pharmacology, pharmacokinetics and toxicity
Acori Tatarinowii Rhizoma (ATR, Shi Chang Pu in Chinese), a natural product with multiple targets in various diseases. This review provides the comprehensive summary of the chemical composition, pharmacological effects, pharmacokinetics parameters and toxicity of ATR. The results indicated that ATR possesses a wide spectrum of chemical composition, including volatile oil, terpenoids, organic acids, flavonoids, amino acids, lignin, carbohydrates and so on. Accumulating evidence from various studies has shown that ATR exerts a wide range of pharmacological properties, including protecting nerve cells, alleviating learning an...
Source: Frontiers in Pharmacology - March 16, 2023 Category: Drugs & Pharmacology Source Type: research
DL-3-n-butylphthalide (NBP) alleviates poststroke cognitive impairment (PSCI) by suppressing neuroinflammation and oxidative stress
In this study, we aimed to investigate the influences of NBP on cognitive function in an ischemic reperfusion (I/R) rat model. Our results showed that NBP profoundly decreased neurological scores, reduced cerebral infarct areas and enhanced cerebral blood flow (CBF). NBP potently alleviated poststroke cognitive impairment (PSCI) including depression-like behavior and learning, memory and social cognition impairments, in I/R rats. NBP distinctly suppressed the activation of microglia and astrocytes and improved neuron viability in the ischemic brain. NBP inhibited the expression of inflammatory cytokines, including interleu...
Source: Frontiers in Pharmacology - January 11, 2023 Category: Drugs & Pharmacology Source Type: research
Specific signature biomarkers highlight the potential mechanisms of circulating neutrophils in aneurysmal subarachnoid hemorrhage
Conclusion: We identified core regulatory genes influencing the transcription profiles of circulating neutrophils after the rupture of intracranial aneurysms using bioinformatics analysis and machine learning algorithms. This study provides new insight into the mechanism of peripheral immune response and inflammation after aSAH.
Source: Frontiers in Pharmacology - November 10, 2022 Category: Drugs & Pharmacology Source Type: research
Detection of acute ischemic stroke and backtracking stroke onset time via machine learning analysis of metabolomics
Biomed Pharmacother. 2022 Sep 8;155:113641. doi: 10.1016/j.biopha.2022.113641. Online ahead of print.ABSTRACTThe time window from stroke onset is critical for the treatment decision. However, in unknown onset stroke, it is often difficult to determine the exact onset time because of the lack of assessment methods, which can result in controversial and random treatment decisions. Previous studies have shown that serum biomarkers, in addition to imaging assessment, are useful for determining the stroke onset time. However, as yet there are no specific biomarkers or corresponding methodologies that are accurate and effective ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 11, 2022 Category: Drugs & Pharmacology Authors: Yiheng Zhang Dayu Zhu Tao Li Xiaoya Wang Lili Zhao Xiaofei Yang Meijuan Dang Ye Li Yulun Wu Ziwei Lu Jialiang Lu Yating Jian Heying Wang Lei Zhang Xiaoyun Lu Ziyu Shen Hong Fan Wenshan Cai Guilian Zhang Source Type: research
A novel phosphodiesterase 9A inhibitor LW33 protects against ischemic stroke through the cGMP/PKG/CREB pathway
CONCLUSION: LW33 inhibited cell apoptosis and promoted neuronal repair to alleviate OGD/R and MCAO induced pathological alterations via the cGMP/PKG/CREB pathway, indicating that LW33 may be a promising therapeutic target for ischemic stroke.PMID:35490726 | DOI:10.1016/j.ejphar.2022.174987
Source: European Journal of Pharmacology - May 1, 2022 Category: Drugs & Pharmacology Authors: Jia-Yi You Xin-Wei Liu Ying-Xia Bao Zheng-Nan Shen Quan Wang Gong-Yun He Jing Lu Ji-Guo Zhang Jian-Wen Chen Pei-Qing Liu Source Type: research
A review on the neuroprotective effect of berberine against chemotherapy-induced cognitive impairment
Curr Drug Targets. 2022 Mar 3. doi: 10.2174/1389450123666220303094752. Online ahead of print.ABSTRACTChemobrain is one of the major side effects of chemotherapy, despite increased research, the mechanisms underlying chemotherapy-induced cognitive changes remain unknown. Though, several possibly important candidate mechanisms have been identified and will be studied further in the future. Chemobrain is characterized by memory loss, cognitive impairment, difficulty in language, concentration, acceleration, and learning. The major characteristic of chemobrain is oxidative stress, mitochondrial dysfunction, immune dysregulatio...
Source: Current Drug Targets - March 4, 2022 Category: Drugs & Pharmacology Authors: Kuleshwar Sahu Sukhdev Singh Bhawna Devi Charan Singh Arti Singh Source Type: research
