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A review on the neuroprotective effect of berberine against chemotherapy-induced cognitive impairment
Curr Drug Targets. 2022 Mar 3. doi: 10.2174/1389450123666220303094752. Online ahead of print.ABSTRACTChemobrain is one of the major side effects of chemotherapy, despite increased research, the mechanisms underlying chemotherapy-induced cognitive changes remain unknown. Though, several possibly important candidate mechanisms have been identified and will be studied further in the future. Chemobrain is characterized by memory loss, cognitive impairment, difficulty in language, concentration, acceleration, and learning. The major characteristic of chemobrain is oxidative stress, mitochondrial dysfunction, immune dysregulatio...
Source: Current Drug Targets - March 4, 2022 Category: Drugs & Pharmacology Authors: Kuleshwar Sahu Sukhdev Singh Bhawna Devi Charan Singh Arti Singh Source Type: research

Predicting 1-Hour Thrombolysis Effect of r-tPA in Patients With Acute Ischemic Stroke Using Machine Learning Algorithm
Conclusion: This study demonstrated that the GBDT model with the seven variables could better predict the early thrombolysis effect of r-tPA.
Source: Frontiers in Pharmacology - January 3, 2022 Category: Drugs & Pharmacology Source Type: research

N-oleoylethanolamine  - phosphatidylcholine complex loaded, DSPE-PEG integrated liposomes for efficient stroke
Drug Deliv. 2021 Dec;28(1):2525-2533. doi: 10.1080/10717544.2021.2008058.ABSTRACTCausing more and more deaths, stroke has been a leading cause of death worldwide. However, success in clinical stroke trials has remained elusive. N-oleoylethanolamine (OEA) was an endogenous highly hydrophobic molecule with outstanding neuroprotective effect. In this article, hydrogen bonds were successfully formed between OEA and soybean phosphatidylcholine (SPC). The synthetic OEA-SPC complex and DSPE-PEG were self-assembled into liposomes (OEA NPs), with OEA-SPC loaded in the core and PEG formed a hydrophilic shell. Hence, highly hydrophob...
Source: Drug Delivery - November 29, 2021 Category: Drugs & Pharmacology Authors: Xiangrui Yang Shichao Wu Source Type: research

Effects of Naodesheng tablets on amyloid beta-induced dysfunction: A traditional Chinese herbal formula with novel therapeutic potential in Alzheimer's disease revealed by systems pharmacology
In conclusion, this is the first study to provide a comprehensive systems pharmacology approach to elucidate the potential therapeutic mechanism of NDS tablets for AD treatment. We suggest that the protective effects of NDS in neurodegenerative conditions could be partly attributed to its role in improving synaptic plasticity and inhibiting neuroinflammation via NF-κB signaling pathway inhibition and cAMP/PKA/CREB signaling pathway activation.PMID:34328103 | DOI:10.1016/j.biopha.2021.111916
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 30, 2021 Category: Drugs & Pharmacology Authors: Baoyue Zhang Jun Zhao Pengfei Guo Zhe Wang Lvjie Xu Ailin Liu Guanhua Du Source Type: research

Purine metabolite-based machine learning models for risk prediction, prognosis, and diagnosis of coronary artery disease
Biomed Pharmacother. 2021 Jul;139:111621. doi: 10.1016/j.biopha.2021.111621. Epub 2021 May 10.ABSTRACTAlterations in xanthine oxidase activity are known to be pathologically influential on coronary artery disease (CAD), but the association between purine-related blood metabolites and CAD has only been partially elucidated. We performed global metabolomics profiling and network analysis on blood samples from the Wonju and Pyeongchang (WP) cohort study (n = 2055) to elucidate the importance of purine related metabolites associated with potential CAD risk. Then, 5 selected serum metabolites were quantified from the WP cohort,...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 10, 2021 Category: Drugs & Pharmacology Authors: Sunhee Jung Eunyong Ahn Sang Baek Koh Sang-Hak Lee Geum-Sook Hwang Source Type: research

Impact of COVID-19 pandemic lockdown on occupational therapy practice and use of telerehabilitation - A cross sectional study
CONCLUSIONS: The COVID-19 pandemic lockdown experiences made us rethink the current approach of therapy services into alternative method (mixed mode) delivery of occupational therapy practice, which is including the combined method of video-based (telerehabilitation) consultation and face to face intervention.PMID:34002837 | DOI:10.26355/eurrev_202105_25845
Source: European Review for Medical and Pharmacological Sciences - May 18, 2021 Category: Drugs & Pharmacology Authors: B Ganesan K N K Fong S K Meena P Prasad R K Y Tong Source Type: research

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