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Total 2114 results found since Jan 2013.

Insufficient Warfarin Therapy Is Associated With Higher Severity of Stroke Than No Anticoagulation in Patients With Atrial Fibrillation and Acute Anterior-Circulation Stroke.
CONCLUSIONS: Insufficient VKA therapy on admission was associated with higher severity of stroke and higher prevalence of proximal artery occlusion in patients with AF and acute anterior-circulation stroke compared with no anticoagulant medication. PMID: 29269702 [PubMed - as supplied by publisher]
Source: Circulation Journal - December 21, 2017 Category: Cardiology Authors: Sakamoto Y, Okubo S, Nito C, Suda S, Matsumoto N, Nishiyama Y, Aoki J, Shimoyama T, Kanamaru T, Suzuki K, Mishina M, Kimura K Tags: Circ J Source Type: research

Non-vitamin K-dependent oral anticoagulants have a positive impact on ischaemic stroke severity in patients with atrial fibrillation
ConclusionNOAC intake before stroke did reduce the probability of severe stroke on hospital admission and poor functional outcome at hospital discharge as similarly demonstrated for phenprocoumon patients with an INR  ≥ 2 on admission.
Source: Europace - April 27, 2017 Category: Cardiology Source Type: research

Use of Non-vitamin K Antagonist Oral Anticoagulants for Stroke Prevention across the Stroke Spectrum: Progress and Prospects.
Abstract Multiple randomized controlled trials and many real-world evidence studies have consistently shown that non-vitamin K antagonist oral anticoagulants (NOACs) are preferable to vitamin K antagonists for thromboembolic stroke prevention in the majority of patients with atrial fibrillation (AF). However, their role in the management of patients with AF and comorbidities, as well as in other patient populations with a high risk of stroke, such as patients with prior embolic stroke of undetermined source (ESUS) and those with atherosclerosis, is less clear. There is now increasing evidence suggesting that NOACs...
Source: Thrombosis and Haemostasis - January 7, 2021 Category: Hematology Authors: Camm AJ, Atar D Tags: Thromb Haemost Source Type: research

Altered Properties of Neurons and Astrocytes and the Effects of Food Components in Stroke-Prone Spontaneously Hypertensive Rats
In this study, we obtained information using PubMed, ScienceDirect, and Web of Science. We searched for the functions of neurons and astrocytes and the molecular mechanism of ischemic stroke induction. We summarized the recent literature on the underlying mechanisms of stroke onset in SHRSP and the alleviating effects of typical food-derived phytochemical components. Neuronal death in SHRSP is induced by hypoxia-reoxygenation, suggesting the involvement of oxidative stress. Furthermore, the production of lactate, l-serine, and glial cell line-derived neurotrophic factor in SHRSP-derived astrocytes was reduced compared with...
Source: Journal of Cardiovascular Pharmacology - June 1, 2021 Category: Cardiology Tags: Review Article Source Type: research

Early Versus Delayed Non-Vitamin K Antagonist Oral Anticoagulant Therapy After Acute Ischemic Stroke in Atrial Fibrillation (TIMING): A Registry-Based Randomized Controlled Noninferiority Study
CONCLUSIONS: Early initiation was noninferior to delayed start of NOAC after acute ischemic stroke in patients with atrial fibrillation. Numerically lower rates of ischemic stroke and death and the absence of symptomatic intracerebral hemorrhages implied that the early start of NOAC was safe and should be considered for acute secondary stroke prevention in patients eligible for NOAC treatment.REGISTRATION: URL: http://www.CLINICALTRIALS: gov; Unique identifier: NCT02961348.PMID:36065821 | DOI:10.1161/CIRCULATIONAHA.122.060666
Source: Circulation - September 6, 2022 Category: Cardiology Authors: Jonas Oldgren Signild Åsberg Ziad Hijazi Per Wester Maria Bertilsson Bo Norrving National TIMING Collaborators Source Type: research

0528 : Incidence and predictors of stroke among patients with chronic heart failure
Conclusion In our study, it seems that femal patients were at lower risk of stroke, in the other hand, prior history of myocardial fraction was predictor of stroke; however the severity of left ventricule systolic dysfunction did not influence the risk of embolic events. The author hereby declares no conflict of interest
Source: Archives of Cardiovascular Diseases Supplements - June 15, 2016 Category: Cardiology Source Type: research

Use of Intravenous Recombinant Tissue Plasminogen Activator in Acute Ischemic Stroke Patients Taking Non-Vitamin K Antagonist Oral Anticoagulants (NOACs) Before Stroke.
CONCLUSIONS: -While experience of using rt-PA in ischemic stroke patients on a NOAC is limited, these preliminary observations suggest that rt-PA appears to be reasonably well tolerated without prohibitive risks for adverse events among selected NOAC treated patients. Future study should evaluate the safety and efficacy of intravenous rt-PA in ischemic stroke patients taking NOACs. PMID: 28119380 [PubMed - as supplied by publisher]
Source: Circulation - January 23, 2017 Category: Cardiology Authors: Xian Y, Federspiel JJ, Hernandez AF, Laskowitz D, Schwamm LH, Bhatt DL, Smith EE, Fonarow GC, Peterson ED Tags: Circulation Source Type: research

Assessment of 25-hydroxy vitamin D in stroke patients based on severity and type: a cross-sectional study
This study showed that low 25(OH) vit D serum level is common in male but there was not any relation between serum level of 25(OH) vit D, type, and severity of stroke.
Source: Comparative Clinical Pathology - March 16, 2017 Category: Pathology Source Type: research

The PAr index, an indicator reflecting altered vitamin B-6 homeostasis, is associated with long-term risk of stroke in the general population: the Hordaland Health Study (HUSK).
Conclusions: Higher plasma PAr was independently associated with increased risk of incident stroke in all participants and across all subgroups stratified by conventional risk predictors. Our novel findings point to and expand the range of inflammation and immune activation processes that may be relevant for the pathogenesis and prevention of stroke. This trial was registered at clinicaltrials.gov as NCT03013725. PMID: 29381795 [PubMed - in process]
Source: The American Journal of Clinical Nutrition - January 1, 2018 Category: Nutrition Authors: Zuo H, Tell GS, Ueland PM, Nygård O, Vollset SE, Midttun Ø, Meyer K, Ulvik A Tags: Am J Clin Nutr Source Type: research

Drug treatment strategies for osteoporosis in stroke patients.
Authors: Hsieh CY, Sung SF, Huang HK Abstract Introduction: Osteoporosis and subsequent fractures are well-recognized complications of stroke. However, drug treatment strategies for osteoporosis after stroke have been rarely discussed in the current guidelines for the management of stroke or osteoporosis.Areas covered: The authors review the epidemiology, characteristics, pathophysiology, and risk prediction of post-stroke osteoporosis and fractures. Then they provide an overview of existing evidence regarding drug treatment strategies for osteoporosis in stroke patients. They also review the effects on bone minera...
Source: Expert Opinion on Pharmacotherapy - March 11, 2020 Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research

Association between Vitamin D and Risk of Stroke: A PRISMA-Compliant Systematic Review and Meta-Analysis
Conclusions: Our analysis indicated that lower circulating level of vitamin D was associated with an elevated risk of stroke, but extra supplement of vitamin D failed to show benefit in decreasing the risk of stroke. Further research and study are also needed to show the role of vitamin D in relation to stroke.Eur Neurol
Source: European Neurology - July 29, 2021 Category: Neurology Source Type: research

Vitamin E supplementation (alone or with other antioxidants) and stroke: a meta-analysis
CONCLUSIONS: Supplementation with vitamin E alone is not associated with stroke reduction. Instead, supplementation of vitamin E with other antioxidants reduces the incidence of ischemic stroke but increases the risk of hemorrhagic stroke, cancelling any beneficial effect derived. Thus, vitamin E is not recommended in stroke prevention.SYSTEMATIC REVIEW REGISTRATION: PROSPERO registration no. CRD42022258259.PMID:37698992 | DOI:10.1093/nutrit/nuad114
Source: Atherosclerosis - September 12, 2023 Category: Cardiology Authors: Enrico Maggio Valeria Proietti Bocchini Roberto Carnevale Pasquale Pignatelli Francesco Violi Lorenzo Loffredo Source Type: research

Effect of Low-Dose Aspirin on Functional Outcome From Cerebral Vascular Events in Women Original Contributions
Conclusions— Results from this large randomized clinical trial provide evidence that 100 mg of aspirin every other day may reduce the risk of ischemic cerebral vascular events but does not have differential effects on functional outcomes from stroke.
Source: Stroke - January 18, 2013 Category: Neurology Authors: Rist, P. M., Buring, J. E., Kase, C. S., Kurth, T. Tags: Acute Cerebral Infarction, Epidemiology Original Contributions Source Type: research