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Total 703 results found since Jan 2013.

Alteplase Therapy for Acute Ischemic Stroke in Pregnancy: Two Case Reports and a Systematic Review of the Literature
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Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 10, 2019 Category: Drugs & Pharmacology Authors: Klayton M. Ryman, Wilson D. Pace, Shawn Smith, Gabriel V. Fontaine Tags: Review of Therapeutics Source Type: research

E-191 Influence of socioeconomic factors on the development of post-stroke depression in aneurysmal subarachnoid hemorrhage survivors
ConclusionThe overall risk of developing a new depression disorder after aSAH was 16% in this retrospective study. The female sex was close to 4 times and substance use were six and half time more likely to develop new depressive symptoms; therefore, these risk factors should be considered when screening patients for depression after aSAH.Disclosures D. Lim: None. C. Abdi: None. L. George: None. K. Lim: None. M. Amruthur: None. A. Gonzalez: None. K. Prijoles: None. H. Haughn: None. J. Keen: None. E. Federico: None. C. Galang: None. B. Gulek: None. D. Bass: None. R. Meyer: None. D. Coppel: None. C. Kelly: None. L. Kim: None. M. Levitt: None.
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Lim, D., Abdi, C., George, L., Lim, K., Amruthur, M., Gonzalez, A., Prijoles, K., Haughn, H., Keen, J., Federico, E., Galang, C., Gulek, B., Bass, D., Meyer, R., Coppel, D., Kelly, C., Kim, L., Levitt, M. Tags: SNIS 19th annual meeting electronic poster abstracts Source Type: research

APRIL: A double-blind, placebo-controlled, randomized, Phase Ib/IIa clinical study of ApTOLL for the treatment of acute ischemic stroke
In the reperfusion era, a new paradigm of treating patients with endovascular treatment (EVT) and neuroprotective drugs is emerging as a promising therapeutic option for patients with acute ischemic stroke (AIS). In this context, ApTOLL, a Toll-like receptor 4 (TLR4) antagonist with proven neuroprotective effect in preclinical models of stroke and a very good pharmacokinetic and safety profile in healthy volunteers, is a promising first-in-class aptamer with the potential to address this huge unmet need. This protocol establishes the clinical trial procedures to conduct a Phase Ib/IIa clinical study (APRIL) to assess ApTOL...
Source: Frontiers in Neurology - February 24, 2023 Category: Neurology Source Type: research

Elabela, a Novel Peptide, Exerts Neuroprotective Effects Against Ischemic Stroke Through the APJ/miR-124-3p/CTDSP1/AKT Pathway
In conclusion, these results indicated that ELA could alleviate neuronal apoptosis and axonal damage by upregulating miR-124-3p and activating the CTDSP1/AKT signaling pathway. This study, for the first time, verified the protective effect of ELA against neuronal injury after ischemia and revealed the underlying mechanisms. We demonstrated the potential for the use of ELA as a therapeutic agent in the treatment of ischemic stroke.PMID:37106272 | DOI:10.1007/s10571-023-01352-6
Source: Cellular and Molecular Neurobiology - April 27, 2023 Category: Cytology Authors: Kang-Long Zhang Shuang-Mei Li Jing-Yu Hou Ying-Hui Hong Xu-Xiang Chen Chang-Qing Zhou Hao Wu Guang-Hui Zheng Chao-Tao Zeng Hai-Dong Wu Jia-Ying Fu Tong Wang Source Type: research

Study links severe restless legs syndrome to increased risk of stroke
Increased restless legs syndrome severity is associated with subsequent increased risk of stroke, researchers report. The study group comprised 72,916 female registered nurses ages 41-58 years in 2005, free of diabetes, stroke, and pregnancy at the baseline.
Source: ScienceDaily Headlines - June 8, 2015 Category: Science Source Type: news

Detection of multiple annexin autoantibodies in a patient with recurrent miscarriages, fulminant stroke and seronegative antiphospholipid syndrome.
Authors: Scholz P, Auler M, Brachvogel B, Benzing T, Mallman P, Streichert T, Klatt AR Abstract Anti-phospholipid syndrome (APS) is one of the main causes for recurrent miscarriages. The diagnosis of APS is based on the occurrence of clinical symptoms such as thrombotic events or obstetric complications as well as the detection of antiphospholipid antibodies directed against β2-glycoprotein I and cardiolipin, or a positive lupus anticoagulant assay. However, there is a subpopulation of patients with clinical symptoms of APS, but the lack of serological markers (seronegative APS). In addition, a large proportion of...
Source: Biochemia Medica - June 29, 2016 Category: Biochemistry Tags: Biochem Med (Zagreb) Source Type: research

Neonatal arterial ischemic stroke: Which thrombotic biological risk factors to investigate and which practical consequences?
Abstract All biological risk factors that have been previously identified to increase the risk of thrombosis in adults, have also been studied in neonates with arterial Ischemic Stroke (NAIS), but most studies were retrospective and included relatively low numbers of affected children. We therefore could not suggest recommendations with a strong level of evidence and only expert proposals potentially useful for clinical practice will be presented in this text. Despite these limitations, the extensive analysis of published data supported that factor V Leiden (FVL) and increased levels of Lp(a) could be significant ...
Source: Archives de Pediatrie - September 1, 2017 Category: Pediatrics Authors: Perez T, Valentin JB, Saliba E, Gruel Y Tags: Arch Pediatr Source Type: research

Troubling Stroke Trend Among U.S. Moms-to-Be
WEDNESDAY, Jan. 24, 2018 -- A rare type of stroke is on the rise among pregnant women in the United States, a new study finds. This type of stroke is called spontaneous subarachnoid hemorrhage. It ' s potentially life-threatening and occurs when blood...
Source: Drugs.com - Daily MedNews - January 24, 2018 Category: General Medicine Source Type: news

The role of intraoperative stroke volume variation on bleeding during functional endoscopic sinus surgery.
CONCLUSIONS: Targeting SVV larger than 12%, achieves a possible reduction of the intraoperative bleeding in patients undergoing FESS. PMID: 29745623 [PubMed - as supplied by publisher]
Source: Minerva Anestesiologica - May 12, 2018 Category: Anesthesiology Tags: Minerva Anestesiol Source Type: research

841: Stroke in pregnancy
In the US, stroke associated with pregnancy occurs in about 35 per 100,000 births. Prior studies have focused on national registries or medico-legal case series. Our objectives were to 1) describe type, antecedent events, and outcomes with strokes and 2) compare women with hypertensive disorders versus those without, as well as those with stroke in antepartum versus postpartum periods.
Source: American Journal of Obstetrics and Gynecology - December 25, 2018 Category: OBGYN Authors: Corey Clifford, Nana-Ama Ankumah, Andrew Valenzuela, Agnes Ditishiem, Baha Sibai Tags: Poster Session IV Source Type: research

Preeclampsia Linked to Later Stroke Risk, Aspirin May Help Preeclampsia Linked to Later Stroke Risk, Aspirin May Help
Having preeclampsia or other forms of hypertension during pregnancy puts women at increased risk of later stroke, which may be mitigated by long-term use of aspirin, a new study suggests.Medscape Medical News
Source: Medscape Medical News Headlines - January 3, 2019 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news

Risk for Stroke in Pregnancy and the Postpartum Period Risk for Stroke in Pregnancy and the Postpartum Period
Dr Mark Alberts discusses recent results from a study presented at the AAN 2019 Annual Meeting evaluating the risk for stroke during pregnancy and in the postpartum period.Medscape Neurology
Source: Medscape Critical Care Headlines - June 18, 2019 Category: Intensive Care Tags: Neurology & Neurosurgery Commentary Source Type: news

Stroke During Pregnancy May Be on the Rise in US Stroke During Pregnancy May Be on the Rise in US
Stroke risk factors are also increasing in young women and more needs to be done to identify and treat high-risk patients in early pregnancy, authors of a new study urge.Medscape Medical News
Source: Medscape Neurology and Neurosurgery Headlines - January 16, 2020 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news

Extending the window for thrombolysis for treatment of acute ischemic stroke during pregnancy: a review.
Abstract Historically, safety of intravenous recombinant tissue plasminogen activator (IV rt-PA) for the treatment of acute ischemic stroke (AIS) is limited to use within 4.5 hours from symptom onset. Recent studies suggest the treatment window may be extended when patients have salvageable brain tissue on advanced neuroimaging. This paper describes a novel use of IV rt-PA for treatment of AIS in a pregnant patient within an extended-time window (>4.5 hours, and <9hrs) based on advanced neuroimaging with a favorable outcome. PMID: 32920999 [PubMed - as supplied by publisher]
Source: BJOG : An International Journal of Obstetrics and Gynaecology - September 11, 2020 Category: OBGYN Authors: Dinehart E, Leon Guerrero CR, Pham A, Chandra S, Petersen SM, Bathgate S, Ahmadzia HK Tags: BJOG Source Type: research