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A meta-analysis of the association of atrial septal abnormalities and atrial vulnerability
Conclusions: Atrial septal abnormalities can increase the risk of atrial vulnerability, and atrial arrhythmia caused by atrial septal abnormalities may be one of the mechanisms of CS.
Source: Medicine - September 3, 2021 Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research

Racial Differences in the Prevalence of Diagnosed Atrial Fibrillation Among Hospitalized Patients
Atrial fibrillation (AF) will affect at least 12 million people in the United States by 2030. Atrial fibrillation is associated with an increased risk for stroke and death and contributes to substantial costs and resource use.1 Considerable efforts are devoted to optimize AF management and mitigate its negative sequalae. However, the literature suggests the presence of racial disparities in the management of AF in the United States. Recent studies showed that direct oral anticoagulant, pulmonary vein isolation, and left atrial appendage closure are less commonly used among patients of non-White race.
Source: Mayo Clinic Proceedings - September 1, 2021 Category: Internal Medicine Authors: Mohammed Osman, Abhishek J. Deshmukh, David R. Holmes, Mohamad Alkhouli Tags: Letter to the editor Source Type: research

Prescribing of direct oral anticoagulants and warfarin to older people with atrial fibrillation in UK general practice: a cohort study
Anticoagulation for stroke prevention in atrial fibrillation (AF) has, historically, been under-used in older people. The aim of this study was to investigate prescribing of oral anticoagulants (OACs) for peop...
Source: BMC Medicine - August 31, 2021 Category: Internal Medicine Authors: Anneka Mitchell, Julia Snowball, Tomas J. Welsh, Margaret C. Watson and Anita McGrogan Tags: Research article Source Type: research

Importance of attributes and willingness to pay for oral anticoagulant therapy in patients with atrial fibrillation in China: A discrete choice experiment
by Jiaxi Zhao, Hao Wang, Xue Li, Yang Hu, Vincent K. C. Yan, Carlos K. H. Wong, Yutao Guo, Marco K. H. Cheung, Gregory Y. H. Lip, Chung-Wah Siu, Hung-Fat Tse, Esther W. Chan BackgroundAdherence to oral anticoagulant therapy in patients with atrial fibrillation (AF) in China is low. Patient preference, one of the main reasons for discontinuation of oral anticoagulant therapy, is an unfamiliar concept in China. Methods and findingsA discrete choice experiment (DCE) was conducted to quantify patient preference on 7 attributes of oral anticoagulant therapy: antidote (yes/no), food –drug interaction (yes/no), frequency of blo...
Source: PLoS Medicine - August 26, 2021 Category: Internal Medicine Authors: Jiaxi Zhao Source Type: research

Cardiac risk stratification in cancer patients: A longitudinal patient –patient network analysis
by Yuan Hou, Yadi Zhou, Muzna Hussain, G. Thomas Budd, Wai Hong Wilson Tang, James Abraham, Bo Xu, Chirag Shah, Rohit Moudgil, Zoran Popovic, Chris Watson, Leslie Cho, Mina Chung, Mohamed Kanj, Samir Kapadia, Brian Griffin, Lars Svensson, Patrick Collier, Feixiong Cheng BackgroundCardiovascular disease is a leading cause of death in general population and the second leading cause of mortality and morbidity in cancer survivors after recurrent malignancy in the United States. The growing awareness of cancer therapy –related cardiac dysfunction (CTRCD) has led to an emerging field of cardio-oncology; yet, there is limited k...
Source: PLoS Medicine - August 2, 2021 Category: Internal Medicine Authors: Yuan Hou Source Type: research

Association between human immunodeficiency virus serostatus and the prevalence of atrial fibrillation
Atrial fibrillation (AF) leads to increased risk for stroke. Human immunodeficiency virus (HIV) is associated with cardiovascular disease (CVD), although it is unclear if HIV is associated with AF. The purpose of this study was to evaluate the association between HIV serostatus and the prevalence of AF in the Multicenter AIDS Cohort Study. A cross sectional study was conducted among 1674 HIV-infected (HIV+) and uninfected (HIV–) men who completed resting 12-lead electrocardiograms, and/or ambulatory electrocardiogram monitoring. Multivariable logistic regression was used to evaluate the association between AF, defined...
Source: Medicine - July 23, 2021 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Frailty and Clinical Outcomes of Direct Oral Anticoagulants Versus Warfarin in Older Adults With Atrial Fibrillation : A Cohort Study
CONCLUSION: For older adults with AF, apixaban was associated with lower rates of adverse events across all frailty levels. Dabigatran and rivaroxaban were associated with lower event rates only among nonfrail patients.PRIMARY FUNDING SOURCE: National Institute on Aging.PMID:34280330 | DOI:10.7326/M20-7141
Source: Annals of Internal Medicine - July 19, 2021 Category: Internal Medicine Authors: Dae Hyun Kim Ajinkya Pawar Joshua J Gagne Lily G Bessette Hemin Lee Robert J Glynn Sebastian Schneeweiss Source Type: research

The noninferiority of transcatheter aortic valve implantation compared to surgical aortic valve replacement for severe aortic disease: Evidence based on 16 randomized controlled trials
Conclusions: Our analysis shows that TAVI was equal to sAVR in early, midterm and long term mortality for patients with severe aortic disease. In addition, TAVI may be favorable in reducing the incidence of both early, midterm and long term NOAF. However, pooled results showed superiority of sAVR in reducing permanent pacemaker implantation, neurological events, TIA, major vascular complications and reintervention.
Source: Medicine - July 16, 2021 Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research

Comparison of postprocedural new-onset atrial fibrillation between transcatheter and surgical aortic valve replacement: A systematic review and meta-analysis based on 16 randomized controlled trials
Conclusions: Our analysis showed that TAVR was superior to SAVR in decreasing the both short and long term postprocedural NOAF. TAVR was equal to SAVR in early, midterm and long term mortality. In addition, TAVR showed lower incidence of 30-day/in-hospital MI and cardiogenic shock after procedure. However, pooled results showed that TAVR was inferior to SAVR in reducing permanent pacemaker implantation, neurological events, TIA, major vascular complications, and re-intervention.
Source: Medicine - July 16, 2021 Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research

Atrial fibrillation in critically ill patients who received prolonged mechanical ventilation: a nationwide inpatient report
CONCLUSIONS: The prevalence of comorbid AF is increasing, particularly in older patients. AF may lead to poorer prognosis, and high-quality intensive care is imperative for this population.PMID:34247459 | DOI:10.3904/kjim.2020.142
Source: The Korean Journal of Internal Medicine - July 12, 2021 Category: Internal Medicine Authors: Zhen Lin Hedong Han Wei Guo Xin Wei Zhijian Guo Shujie Zhai Shuai Li Yiming Ruan Fangyuan Hu Dongdong Li Jia He Source Type: research

Detection of subclinical atrial fibrillation after cryptogenic stroke using implantable cardiac monitors
CONCLUSIONS: In a real-world population, ICM detected SCAF in more than a quarter of CS patients. This experience confirms the relevance of implanting CS patients, for maximizing the possibilities to detect AF, following failure of Holter monitoring, according to guidelines. However, there is need to demonstrate that shift to oral anticoagulation following SCAF detection is associated with reduced risk of recurrent stroke.PMID:34247889 | DOI:10.1016/j.ejim.2021.06.022
Source: European Journal of Internal Medicine - July 12, 2021 Category: Internal Medicine Authors: Andrea Ungar Francesca Pescini Martina Rafanelli Maria Vittoria De Angelis Massimiliano Faustino Caterina Tomaselli Alfredo Petrone Giovanni Forleo Giovanni Morani Stefano Forlivesi Giulio Molon Alessandro Adami Massimiliano Maines Chiara Stegagno Anna Po Source Type: research

Atrial fibrillation in critically ill patients who received prolonged mechanical ventilation: a nationwide inpatient report
CONCLUSIONS: The prevalence of comorbid AF is increasing, particularly in older patients. AF may lead to poorer prognosis, and high-quality intensive care is imperative for this population.PMID:34247459 | DOI:10.3904/kjim.2020.142
Source: The Korean Journal of Internal Medicine - July 12, 2021 Category: Internal Medicine Authors: Zhen Lin Hedong Han Wei Guo Xin Wei Zhijian Guo Shujie Zhai Shuai Li Yiming Ruan Fangyuan Hu Dongdong Li Jia He Source Type: research

Detection of subclinical atrial fibrillation after cryptogenic stroke using implantable cardiac monitors
CONCLUSIONS: In a real-world population, ICM detected SCAF in more than a quarter of CS patients. This experience confirms the relevance of implanting CS patients, for maximizing the possibilities to detect AF, following failure of Holter monitoring, according to guidelines. However, there is need to demonstrate that shift to oral anticoagulation following SCAF detection is associated with reduced risk of recurrent stroke.PMID:34247889 | DOI:10.1016/j.ejim.2021.06.022
Source: European Journal of Internal Medicine - July 12, 2021 Category: Internal Medicine Authors: Andrea Ungar Francesca Pescini Martina Rafanelli Maria Vittoria De Angelis Massimiliano Faustino Caterina Tomaselli Alfredo Petrone Giovanni Forleo Giovanni Morani Stefano Forlivesi Giulio Molon Alessandro Adami Massimiliano Maines Chiara Stegagno Anna Po Source Type: research

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