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Condition: Atrial Fibrillation

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Total 17201 results found since Jan 2013.

Simvastatin, but Not Atorvastatin, Is Associated with Higher Peak Rivaroxaban Serum Levels and Bleeding: an Asian Cohort Study from Singapore
ConclusionOur findings suggest that concomitant use of simvastatin with rivaroxaban may be associated with bleeding events in an Asian cohort. Further studies using physiologically based pharmacokinetic modelling are required to investigate the drug-drug interactions between these drugs.
Source: Cardiovascular Drugs and Therapy - September 22, 2023 Category: Cardiology Source Type: research

PPP1R12C Promotes Atrial Hypocontractility in Atrial Fibrillation
CONCLUSIONS: Patients with AF exhibit increased levels of PPP1R12C protein compared with controls. PPP1R12C overexpression in mice increases PP1c targeting to MLC2a and causes MLC2a dephosphorylation, which reduces atrial contractility and increases AF inducibility. These findings suggest that PP1 regulation of sarcomere function at MLC2a is a key determinant of atrial contractility in AF.PMID:37737016 | DOI:10.1161/CIRCRESAHA.123.322516
Source: Circulation Research - September 22, 2023 Category: Cardiology Authors: Srikanth Perike Francisco J Gonzalez-Gonzalez Issam Abu-Taha Frederick W Damen Laurin M Hanft Ken S Lizama Anahita Aboonabi Andrielle E Capote Yuriana Aguilar-Sanchez Benjamin Levin Zhenbo Han Arvind Sridhar Jacob Grand Jody Martin Joseph G Akar Chad M Wa Source Type: research

To block or not to block: Targeting SK channels in diseased hearts
Atrial fibrillation (AF) is the most common arrhythmia, affecting more than 1% of general population and reaching over 10% in advanced age in the USA. Atrial fibrillation drastically increases the risk of stroke and promotes development of cardiomyopathy and congestive heart failure. Existing pharmacological approaches using β-blockers and inhibitors of Na+, Ca2+ and K+ channels to treat AF are effective only in 50% of cases. Furthermore, these drugs could affect ventricular tissue promoting proarrhythmic changes in electrical conduction, intracellular Ca2+ homeostasis, or action potential duration (APD).
Source: Journal of Molecular and Cellular Cardiology - September 22, 2023 Category: Cytology Authors: Dmitry Terentyev, Andriy E. Belevych, Bum-Rak Choi, Shanna Hamilton Source Type: research

Oral Anticoagulation Use and Left Atrial Appendage Occlusion in LAAOS III
CONCLUSIONS: The benefit of LAA occlusion was consistent whether patients were receiving OACs or not. LAA occlusion provides thromboembolism reduction in patients independent of OAC use.PMID:37732457 | DOI:10.1161/CIRCULATIONAHA.122.060315
Source: Circulation - September 21, 2023 Category: Cardiology Authors: Stuart J Connolly Jeff S Healey Emilie P Belley-Cote Kumar Balasubramanian Domenico Paparella Katheryn Brady Wilko Reents Bernhard C Danner P J Devereaux Mukul Sharma Chinthanie Ramasundarahettige Salim Yusuf Richard P Whitlock Source Type: research

A comparative study of thoracoscopic left atrial appendage clipping versus stapled resection
CONCLUSIONS: The clipping group demonstrated a higher rate of complete LAA closure compared to the stapled resection group. Close monitoring of patients with residual LAA stumps is essential. Further research with larger cohorts is needed to elucidate impact of residual LAA stump on thromboembolic events.PMID:37734642 | DOI:10.1016/j.athoracsur.2023.09.010
Source: The Annals of Thoracic Surgery - September 21, 2023 Category: Cardiovascular & Thoracic Surgery Authors: Suk Kyung Lim Chu Hyun Kim Ki Hong Choi Joong Hyun Ahn Young Keun On Sung Mok Kim Dong Seop Jeong Source Type: research

Oral Anticoagulation Use and Left Atrial Appendage Occlusion in LAAOS III
CONCLUSIONS: The benefit of LAA occlusion was consistent whether patients were receiving OACs or not. LAA occlusion provides thromboembolism reduction in patients independent of OAC use.PMID:37732457 | DOI:10.1161/CIRCULATIONAHA.122.060315
Source: Circulation - September 21, 2023 Category: Cardiology Authors: Stuart J Connolly Jeff S Healey Emilie P Belley-Cote Kumar Balasubramanian Domenico Paparella Katheryn Brady Wilko Reents Bernhard C Danner P J Devereaux Mukul Sharma Chinthanie Ramasundarahettige Salim Yusuf Richard P Whitlock Source Type: research

Primary Aldosteronism
Am Fam Physician. 2023 Sep;108(3):273-277.ABSTRACTPrimary aldosteronism is the underlying cause of hypertension in primary care settings in approximately 6% of cases, and it is even more common in patients with resistant hypertension. However, it is estimated that only about 2% of patients who have risk factors for primary aldosteronism have been formally tested or diagnosed. The first step in the diagnosis of primary aldosteronism is case detection and involves testing patients who are at risk, including individuals with resistant hypertension, as well as those with well-controlled hypertension and a first-degree relative...
Source: American Family Physician - September 19, 2023 Category: Primary Care Authors: Keith B Quencer J B Rugge Olga Senashova Source Type: research

Cost of treatment failure: Medicare spending on stroke for atrial fibrillation patients not receiving anticoagulation
It is well known that atrial fibrillation (AF) patients not receiving anticoagulants are at higher risk of Ischemic Stroke (IS).
Source: Journal of the Neurological Sciences - September 19, 2023 Category: Neurology Authors: Steven D. Culler, W. Frank Peacock, April W. Simon Source Type: research

IJERPH, Vol. 20, Pages 6783: Reaching the Frail Elderly for the Diagnosis and Management of Atrial Fibrillation & mdash;REAFEL
CONCLUSIONS: CardioShare was successfully implemented for AF evaluation in primary care.
Source: International Journal of Environmental Research and Public Health - September 19, 2023 Category: Environmental Health Authors: Carsten Bamberg Caroline Thorup Ladegaard Mathias Aalling Dorthea Marie Jensen Christoffer L æssøe Madsen Sadaf Kamil Henrik Gudbergsen Thomas Saxild Michaela Louise Schi øtz Julie Grew Luana Sandoval Castillo Iben Tousgaard Rie Laurine Rosenthal Johan Tags: Article Source Type: research

ISCHEMIC STROKE AND MAJOR BLEEDING WHILE ON DIRECT ORAL ANTICOAGULANTS IN NA ÏVE PATIENTS WITH ATRIAL FIBRILLATION: IMPACT OF RESUMPTION OR DISCONTINUATION OF ANTICOAGULANT TREATMENT. A population-based study.
We assessed the cumulative incidence of recurrent stroke, major bleeding and all-cause mortality associated with restarting antithrombotic treatment, in patients experiencing an anticoagulation-related event (stroke or major bleeding), occurred during anticoagulation therapy for AF.Methods and Results.We performed a retrospective population-based analysis on linked claims data of patients resident in the Veneto Region, treated with DOACs for AF and discharged (2013 −2020) from the hospital for stroke, intracranial haemorrhage (ICH), and major bleeding.
Source: International Journal of Cardiology - September 16, 2023 Category: Cardiology Authors: N. Gennaro, E. Ferroni, M. Zorzi, G. Denas, V. Pengo Source Type: research

Off-Label Reduced Dose Apixaban in Older Adults With Atrial Fibrillation and Associated Outcomes
CONCLUSION AND RELEVANCE: Older adults with nonvalvular AF are commonly prescribed lower-than-recommended doses of apixaban. However, no significant association was found between empiric off-label reduced dosing and stroke or bleeding outcomes.PMID:37712551 | DOI:10.1177/10600280231199137
Source: The Annals of Pharmacotherapy - September 15, 2023 Category: Drugs & Pharmacology Authors: Ashley M Campbell Elizabeth Pae Eunice Lee Timothy Jacisin Alina Price Jessica DeAngelo Source Type: research

Report on Cardiovascular Health and Diseases in China 2022: an Updated Summary
Biomed Environ Sci. 2023 Aug 20;36(8):669-701. doi: 10.3967/bes2023.106.ABSTRACTIn the past 30 years, the accessibility and quality index of medical care have made remarkable progress in China, ranking the first among middle-income countries. Many cardiovascular technologies are at or near the world's leading level, and significant progress has been achieved in China solving the problem of "treatment difficulty" of cardiovascular diseases (CVD). However, due to the prevalence of unhealthy lifestyles among Chinese residents, a huge population with CVD risk factors, accelerated population aging, and other reasons, the incide...
Source: Biomedical and Environmental Sciences : BES - September 15, 2023 Category: Biomedical Science Authors: Writing Committee Of The Report On Cardiovascular Health And Diseases In China The Source Type: research