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Condition: Hypertension
Procedure: Heart Transplant

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Total 156 results found since Jan 2013.

Quantitative computed tomography of pulmonary emphysema and ventricular function in chronic obstructive pulmonary disease patients with pulmonary hypertension.
CONCLUSION: The study revealed that percent emphysema is correlated with RV dysfunction among COPD patients with PH. Based on our findings, percent emphysema can be considered for use as an indicator to predict the severity of right ventricular dysfunction among COPD patients. PMID: 25469102 [PubMed - in process]
Source: Korean Journal of Radiology - December 6, 2014 Category: Radiology Tags: Korean J Radiol Source Type: research

RV-pulmonary arterial coupling predicts outcome in patients referred for pulmonary hypertension
Conclusions The adequacy of RV functional adaptation to afterload predicts survival in patients referred for PH. Whether this can simply be evaluated using RV volumetric imaging will require additional confirmation.
Source: Heart - December 12, 2014 Category: Cardiology Authors: Vanderpool, R. R., Pinsky, M. R., Naeije, R., Deible, C., Kosaraju, V., Bunner, C., Mathier, M. A., Lacomis, J., Champion, H. C., Simon, M. A. Tags: Hypertension Pulmonary vascular disease Source Type: research

Hemodynamic effects of different vasodilators in patients with type II pulmonary hypertension (PH)
Conclusions. Inhaled Iloprost causes favorable changes in preload and afterload of the impaired LV and increases its performance in patients with PH associated with LV systolic dysfunction.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Bautin, A., Tashkhanov, D., Datsenko, S., Fedotov, P., Iakovlev, A., Moiseeva, O., Sitnikova, M. Tags: 4.3 Pulmonary Circulation and Pulmonary Vascular Disease Source Type: research

Epigenetic regulation of smooth muscle cell plasticity
This article is part of a Special Issue entitled: Stress as a fundamental theme in cell plasticity.
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - March 19, 2015 Category: Genetics & Stem Cells Source Type: research

Do diet soft drinks actually make you gain weight?
Conclusion This prospective study found that people who drank diet soft drinks every day experienced greater waist circumference gain over up to nine years of follow-up compared with those who never drank diet drinks (3.04cm gain versus 0.77cm). They also experienced a minimal gain in BMI (+0.05kg/m2) over follow-up, compared with a minimal loss in non-users of diet drinks (-0.41kg/m2). However, this study certainly does not prove that diet drinks, and diet drinks alone, are responsible for these small increases in waist circumference and BMI. People who drank diet drinks tended to have higher BMIs and waist circumferen...
Source: NHS News Feed - April 8, 2015 Category: Consumer Health News Tags: Food/diet Obesity Source Type: news

Has Brazil found the way to better health care?
Under Brazil’s family health program, when a woman learns that she is pregnant, she contacts her local community health agent, who often is a neighbor. Typically, the agent visits her home to arrange an appointment with the neighborhood’s family health team, and the woman visits the health center for an assessment by a nurse assistant and a physician. During the pregnancy, if she misses a prenatal care appointment, the agent checks in on her at home and helps her reschedule her visit. Any prenatal medications she needs are provided free of charge. Brazil — home to the world’s fifth-largest population and seventh-l...
Source: UCLA Newsroom: Health Sciences - June 5, 2015 Category: Universities & Medical Training Source Type: news

Pre-existing diabetes and risks of morbidity and mortality after liver transplantation: A nationwide database study in an Asian population.
CONCLUSION: DM is associated with elevated risk of 90-day post-LTx. Moreover, DM patients with coexisting renal manifestations exhibited an increased postoperative risk of mortality after LTx. PMID: 26048000 [PubMed - as supplied by publisher]
Source: European Journal of Internal Medicine - June 2, 2015 Category: Internal Medicine Authors: Tsai MS, Wang YC, Wang HH, Lee PH, Jeng LB, Kao CH Tags: Eur J Intern Med Source Type: research

Frequency of Cardiovascular Events and Effect on Survival in Liver Transplant Recipients for Cirrhosis Due to Alcoholic or Nonalcoholic Steatohepatitis.
CONCLUSIONS: Cardiovascular events occurred with similar frequency in transplant recipients for nonalcoholic steatohepatitis or alcoholic cirrhosis. Patient survival was affected in both groups, but male patients with concomitant hepatitis C virus infection remained at higher risk for a cardiovascular event after liver transplant. Development of a cardiac evaluation protocol for liver transplant recipients could help monitor these patients. PMID: 26581602 [PubMed - as supplied by publisher]
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - November 17, 2015 Category: Transplant Surgery Authors: Piazza NA, Singal AK Tags: Exp Clin Transplant Source Type: research

Context-Dependent Effects of SOCS3 in Angiotensin II-Induced Vascular Dysfunction and Hypertension in Mice: Mechanisms and Role of Bone Marrow-Derived Cells.
We examined direct effects of Ang II on carotid arteries from SOCS3 deficient (SOCS3+/-) mice and wild-type (WT) littermates using organ culture, followed by testing endothelial function with acetylcholine (Ach). A low concentration of Ang II (1 nmol/L) did not affect Ach-induced vasodilation in WT, but reduced that of SOCS3+/- mice by ~50% (P<0.05). In relation to mechanisms, effects of Ang II in SOCS3+/- mice were prevented by inhibitors of STAT3, IL-6, NF-κB or superoxide. Systemic Ang II (1.4 mg/kg per day for 14 d) also reduced vasodilation to Ach in WT. Surprisingly, SOCS3 deficiency prevented most of the endothe...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 21, 2016 Category: Physiology Authors: Li Y, Kinzenbaw DA, Modrick ML, Pewe LL, Faraci FM Tags: Am J Physiol Heart Circ Physiol Source Type: research

Context-dependent effects of SOCS3 in angiotensin II-induced vascular dysfunction and hypertension in mice: mechanisms and role of bone marrow-derived cells
We examined direct effects of Ang II on carotid arteries from SOCS3-deficient (SOCS3+/–) mice and wild-type (WT) littermates using organ culture and then tested endothelial function with acetylcholine (ACh). A low concentration of Ang II (1 nmol/l) did not affect ACh-induced vasodilation in WT but reduced that of SOCS3+/– mice by ~50% (P < 0.05). In relation to mechanisms, effects of Ang II in SOCS3+/– mice were prevented by inhibitors of STAT3, IL-6, NF-B, or superoxide. Systemic Ang II (1.4 mg/kg per day for 14 days) also reduced vasodilation to ACh in WT. Surprisingly, SOCS3 deficiency prevented mos...
Source: AJP: Heart and Circulatory Physiology - June 30, 2016 Category: Cardiology Authors: Li, Y., Kinzenbaw, D. A., Modrick, M. L., Pewe, L. L., Faraci, F. M. Tags: VASCULAR BIOLOGY AND MICROCIRCULATION Source Type: research

Why Diet Soda Could Actually Prevent You From Losing Weight
Reaching for a diet soda may actually hinder weight loss efforts, a new study done in mice suggests. In experiments, researchers found that the artificial sweetener aspartame, which is found in some diet drinks, may contribute to the development of a condition called “metabolic syndrome,” which involves a cluster of symptoms, including high blood pressure, high cholesterol levels and a large waist size. People with metabolic syndrome face an increased risk of heart disease, stroke and diabetes. The researchers found how aspartame could be linked with metabolic syndrome: Aspartame may stop a key gut enzyme ...
Source: Healthy Living - The Huffington Post - December 7, 2016 Category: Consumer Health News Source Type: news

Cochrane Priority Reviews List: December 2016 Update
Cochrane-wide prioritisation remains an important project, with over 140 priority reviews or updates have been published since it began in January 2015.The December 2016 revision of the Cochrane Priority Reviews List includes new titles from the Cochrane Airways, Anaesthesia, Dementia& Cognitive Improvement, ENT, Epilepsy, Gynaecological, Neuro-oncology and Orphan Cancers, Gynaecology& Fertility, Haematological Malignancies, Heart, Incontinence, Kidney& Transplant, Lung Cancer, Neuromuscular Disease, Oral Health, Skin, Stroke, and Urology Groups.The following titles on the list are open to new authors:Long-acti...
Source: Cochrane News and Events - December 14, 2016 Category: Information Technology Authors: mumoquit at cochrane.org Source Type: news

Sustaining and Improving Current Practices Surrounding Timely Hypertension Management in Pediatric Hematopoietic Stem Cell Patients
Topic Significance& Study Purpose/Background/Rationale: Hypertension (HTN) is a known complication during pediatric hematopoietic stem cell transplant (HSCT). The risks for developing hypertension depend on a variety of factors including the use of drugs (calcineurin inhibitors, steroids, and chemotherapy), total body irradiation (TBI), renal injury, transplant associated thrombotic microangiopathy (TMA) and sinusoidal obstructive syndrome (SOS). Uncontrolled HTN may lead to significant life-threatening complications including impaired renal and heart function, stroke, posterior reversible encephalopathy (PRES) and death.
Source: Biology of Blood and Marrow Transplantation - February 22, 2017 Category: Hematology Authors: Michelle Lewyckyj, Adam S. Nelson, Christopher E. Dandoy, Ashley Teusink, Sonata Jodele, Laura Flesch Source Type: research

Dynamic Changes in Aortic Vascular Stiffness in Patients Bridged to Transplant  With Continuous-Flow Left Ventricular Assist Devices
Conclusions Aortic stiffness is markedly increased immediately post-OHT among patients bridged with CF-LVADs, with attenuation of this increased stiffness over the first year after transplant. These results suggest that aortic vascular properties are dynamic and may be influenced by alterations in flow pulsatility. As more patients are supported with CF-LVADs and as newer pump technology attempts to modulate pulsatility, further research examining the role of alterations in flow patterns on vascular function and the potential resultant systemic sequelae are needed. Graphical abstract
Source: JACC: Heart Failure - March 9, 2017 Category: Cardiology Source Type: research