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ADVANCIS Score Predicts Acute Kidney Injury After Percutaneous Coronary Intervention for Acute Coronary Syndrome.
In conclusion, the ADVANCIS score is a novel, simple, robust tool for predicting the risk of incident AKI after PCI for ACS, and it can aid in risk stratification to monitor patient care. PMID: 29559842 [PubMed - in process]
Source: International Journal of Medical Sciences - March 25, 2018 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Investigation of renalase gene rs2576178 polymorphism in patients with coronary heart disease.
Abstract Renalase gene rs2576178 polymorphism has been demonstrated to be a risk factor of ischemic stroke, essential hypertension and end-stage renal disease, but its association Renalase with risk of coronary artery disease (CAD) has been less reported. Therefore, we detected Renalase rs2576178 polymorphism in 449 CAD patients and 507 healthy controls using matrix-assisted laser desorption/lionization time-of-flight mass spectrometry. It was found GG genotype or G allele of rs2576178 polymorphism was associated with the risk of CAD. Stratified analysis indicated Renalasethis polymorphism significantly increased ...
Source: Bioscience Reports - September 4, 2018 Category: Biomedical Science Authors: Hu N, Wang J, Hu P, Li Z Tags: Biosci Rep Source Type: research

Analysis of genetic and nongenetic factors influencing triglycerides-lowering drug effects based on paired observations
In this study, we assessed both genetic and nongenetic factors that influence drug responses and stratified patients into groups based on differential drug effect and sensitivity. Our methodology of investigating genetic factors and nongenetic factors is applicable to studying differential effects of other drugs, such as statins, and provides an approach to the development of personalized medicine.
Source: BMC Proceedings - September 17, 2018 Category: Biomedical Science Source Type: research

Phospholipase C-related catalytically inactive protein: A novel signaling molecule for modulating fat metabolism and energy expenditure
ConclusionWe propose PRIP as a new therapeutic target for controlling obesity or developing novel anti-obesity drugs.
Source: Journal of Oral Biosciences - May 16, 2019 Category: Biomedical Science Source Type: research

UPLC-QTOF/MS-based metabolomics reveals the mechanism of chronic unpredictable mild stress-induced hypertension in rats.
In this study, using LC-MS-based metabolomics, we established a chronic stress model to demonstrate the mechanisms of stress-induced hypertension. We found that 30 metabolites in chronically stressed rats were changed; of these metabolites, 7 had been upregulated, and 23 had been downregulated, including amino acids, phospholipids, carnitines and fatty acids, many of which are involved in amino acid metabolism, cell membrane injury, ATP supply and inflammation. These metabolites are engaged in dysregulated pathways and will provide a targeted approach to study the mechanism of stress-induced hypertension. PMID: 311775...
Source: Biomedical Chromatography : BMC - June 7, 2019 Category: Biomedical Science Authors: Wu Q, Xia DM, Lan F, Wang YK, Tan X, Sun JC, Wang WZ, Wang R, Peng XD, Liu M Tags: Biomed Chromatogr Source Type: research

Brain functions and unusual β-amyloid accumulation in the hypertensive white matter lesions of rats.
This study used Sprague Dawley (SD) rats with stroke-prone renovascular hypertension (RHRSP) to establish an animal model of hypertensive white matter lesions (WML), so as to explore the brain functions and unusual β-amyloid (Aβ) accumulation in WML. Hypertensive WML and brain dysfunctions were evaluated by measuring the caudal arterial pressure of model rats, and by observing the histomorphological deformations o f the prefrontal lobe, temporal lobe, hippocampus and corpus callosum, as well as by counting of the number of neurons using Hematoxylin and Eosin (H and E) staining, and by evaluating the changes in rat brain ...
Source: Journal of Biological Regulators and Homeostatic Agents - August 8, 2019 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Prevalence and prognosis significance of cardiovascular disease in cancer patients: a population-based study.
CONCLUSIONS: Cancer patients are vulnerable to comorbidity related to heart and cerebral disease. The influence of comorbidities on prognosis is noticeable and specific both for the type of cancer and comorbidities. PMID: 31562288 [PubMed - as supplied by publisher]
Source: Aging - September 26, 2019 Category: Biomedical Science Authors: Liu D, Ma Z, Yang J, Zhao M, Ao H, Zheng X, Wen Q, Yang Y, You J, Qiao S, Yuan J Tags: Aging (Albany NY) Source Type: research

Abdominal Obesity and Its Attribution to All-cause Mortality in the General Population with 14 Years Follow-up: Findings from Shanxi Cohort in China.
Conclusion: WC was an important predictor of death independent of body mass index (BMI). WC should be used as a simple rapid screening and predictive indicator of the risk of death. PMID: 32438960 [PubMed - in process]
Source: Biomedical and Environmental Sciences : BES - April 19, 2020 Category: Biomedical Science Authors: Zhai Y, Ren ZP, Zhang M, Zhang J, Jiang Y, Mi SQ, Wang ZQ, Zhao YF, Song PK, Yin ZX, Zhao WH Tags: Biomed Environ Sci Source Type: research

Impact of salt intake reduction on CVD mortality in Costa Rica: A scenario modelling study
The objective of this study was to estimate the impact of reducing salt intake on CVD mortality in Costa Rica using a scenario simulation model. The Preventable Risk Integrated ModEl (PRIME) was used to estimate the number of deaths that would be averted or delayed in the Costa Rican population by following the national and the international guidelines to reduce salt consumption, according to two scenarios: A) 46% reduction and B) 15% reduction, both at an energy intake of 2171 kcal. The scenarios estimated that between 4% and 13%, respectively, of deaths due to CVD would be prevented or postponed. The hig hest percentages...
Source: PLoS One - January 12, 2021 Category: Biomedical Science Authors: Jaritza Vega-Solano Source Type: research

Impact of Gender on Type II Diabetes Glycemic and Cardiovascular Markers Control and Treatment
CONCLUSION: Both genders exhibited comparable HbA1c levels. Medical treatment optimization along with controlling both measured cardiovascular makers and laboratory result levels was based on comorbidities and complications rather than gender.PMID:33274898 | DOI:10.3923/pjbs.2020.1643.1649
Source: Pakistan Journal of Biological Sciences: PJBS - December 4, 2020 Category: Biomedical Science Authors: Khaled A Alswat Source Type: research

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