Investigation of renalase gene rs2576178 polymorphism in patients with coronary heart disease.

Investigation of renalase gene rs2576178 polymorphism in patients with coronary heart disease. Biosci Rep. 2018 Sep 04;: Authors: Hu N, Wang J, Hu P, Li Z Abstract Renalase gene rs2576178 polymorphism has been demonstrated to be a risk factor of ischemic stroke, essential hypertension and end-stage renal disease, but its association Renalase with risk of coronary artery disease (CAD) has been less reported. Therefore, we detected Renalase rs2576178 polymorphism in 449 CAD patients and 507 healthy controls using matrix-assisted laser desorption/lionization time-of-flight mass spectrometry. It was found GG genotype or G allele of rs2576178 polymorphism was associated with the risk of CAD. Stratified analysis indicated Renalasethis polymorphism significantly increased the risk of CAD in females, smokers and alcoholics. However, there was no significant association between different genotypes of rs2576178 polymorphism and clinical parameters. In summary, Renalasers2576178 polymorphism is associated with increased risk of CAD, but this finding should be confirmed by larger studies with more diverse ethnic populations. PMID: 30181378 [PubMed - as supplied by publisher]
Source: Bioscience Reports - Category: Biomedical Science Authors: Tags: Biosci Rep Source Type: research