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< em > HTRA1 < /em > Variants and the Interaction with Smoking Confer the Genetic Susceptibility to Ischemic Stroke
This study aimed at evaluating the association of HTRA1 with IS and four tagging single-nucleotide polymorphisms (SNPs) were genotyped in a cohort of 4,098 Chinese. The mRNA level of HTRA1 in 72 IS cases and 72 hypertension controls were measured and compared. In whole population, SNP rs2268350 (C>T) was significantly associated with IS incidence (P=0.034). Stratification analysis observed significant association of rs2268350 in male, smoking and drinking populations, rs2672587 (C>G) in smoking and nonsmoking populations and rs3793917 (C>G) in smoking, nonsmoking and nondrinking populations with stroke respectivel...
Source: International Journal of Medical Sciences - March 22, 2021 Category: Biomedical Science Authors: Yuanrui Tian Wuzhuang Tang Song Yang Yanping Zhao Yanchun Chen Xianghai Zhao Chunlan Liu Xiaotian Chen Chong Shen Source Type: research

Multiscale Entropy of the Heart Rate Variability for the Prediction of an Ischemic Stroke in Patients with Permanent Atrial Fibrillation
We examined whether a novel complexity measurement of the heart rate variability called multiscale entropy (MSE) was a useful risk stratification measure of ischemic strokes in patients with permanent AF. Methods and Results We examined 173 consecutive patients (age 69±11 years) with permanent AF who underwent 24-hour Holter electrocardiography from April 2005 to December 2006. We assessed several frequency ranges of the MSE and CHA2DS2-VASc score (1 point for congestive heart failure, hypertension, diabetes, vascular disease, an age 65 to 74 years, and a female sex and 2 points for an age≥75 years and a stroke or trans...
Source: PLoS One - September 1, 2015 Category: Biomedical Science Authors: Eiichi Watanabe et al. Source Type: research

A Nested Case-Control Study to Explore the Association between Immunoglobulin G N-glycans and Ischemic Stroke
CONCLUSION: This study validated that altered IgG N-glycan traits were associated with incident IS in men, suggesting that sex discrepancies might exist in these associations.PMID:37253665 | DOI:10.3967/bes2023.048
Source: Biomedical and Environmental Sciences : BES - May 30, 2023 Category: Biomedical Science Authors: Bi Yan Wang Man Shu Song Jie Zhang Xiao Ni Meng Wei Jia Xing You Xin Wang Source Type: research

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