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Condition: Hypothyroidism

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Total 192 results found since Jan 2013.

ERLEADA ® (apalutamide) Oral Presentations Demonstrate Importance of Prostate Specific Antigen (PSA) as Key Efficacy Indicator and Show Strong Patient Adherence Rates
September 11, 2021 (RARITAN, N.J.) – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced new data demonstrating robust prostate-specific antigen (PSA) response and strong adherence rates in patients with non-metastatic castration-resistant prostate cancer (nmCRPC) treated with ERLEADA® (apalutamide) in the real-world clinical setting. The strong PSA response was also seen in a separate post-hoc analysis that showed a correlation between rapid and deep PSA response and prolonged survival in both metastatic castration-sensitive prostate cancer (mCSPC) and nmCRPC. The post-hoc analysis also suppor...
Source: Johnson and Johnson - September 12, 2021 Category: Pharmaceuticals Source Type: news

Hypothyroidism is associated with clinical outcomes in patients with acute myocardial infarction: subgroup analysis of China PEACE study
ConclusionCompared with euthyroid status, hypothyroid status has an independent predicting value for adverse cardiovascular events in AMI patients. Further investigations are required to illustrate whether treatment of thyroid dysfunction could improve the prognosis of AMI patients.
Source: Endocrine - September 15, 2021 Category: Endocrinology Source Type: research

Association of total cholesterol and atherosclerotic cardiovascular disease in patients with follicular thyroid cancer: A real-world study from Chinese populations
The association between serum total cholesterol (TC) level and incident atherosclerotic cardiovascular disease (ASCVD) in patients with follicular thyroid cancer postthyroidectomy is unknown. This was a retrospective study and patients (n = 384) were divided into low and high TC groups according to the median TC level. Incidence of composite ASCVD (myocardial infarction, ischemic stroke, and cardiovascular death) was compared between these 2 groups and factors contributing to the association of TC and ASCVD were evaluated. Patients in the high TC group were older and more likely to have diabetes and have higher C...
Source: Medicine - October 1, 2021 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

A Treacherous Twist on ECG
The patient is a 61-year-old female with a history of well-controlled hypothyroidism on levothyroxine supplementation and prior suspected cardioembolic stroke on chronic anticoagulation who previously underwent surgical mitral valve repair 1 year previously due to symptoms of severe fatigue with a baseline left ventricular ejection fraction of 55-60% and non-obstructive coronary artery disease. Immediately following surgery, her left ventricular ejection fraction declined to 40%. Postoperatively, she continued to experience fatigue with gradual worsening of her left ventricular ejection fraction to 30%.
Source: The American Journal of Medicine - October 26, 2021 Category: General Medicine Authors: Tyler J. Bonkowski, Christopher M. Madison, Sanjay Dandamudi, David A. McNamara Tags: ECG Image of the Month Source Type: research

Challenges in the Management of Atrial Fibrillation With Subclinical Hyperthyroidism
Subclinical thyroid disorders have a high prevalence among older individuals and women. Subclinical hypothyroidism is diagnosed by elevated serum levels of thyroid-stimulating hormone (TSH) with thyroxine levels within the reference range, and subclinical hyperthyroidism is diagnosed by low TSH in conjunction with thyroxine and triiodothyronine levels within reference ranges. Atrial fibrillation is the most commonly diagnosed cardiac arrhythmia and has been associated with an increased risk of mortality, heart failure, stroke, and depression. Mechanistic data from animal and human physiology studies as well as observationa...
Source: Frontiers in Endocrinology - January 4, 2022 Category: Endocrinology Source Type: research

Mid-Term Outcomes of Heart Transplantation in Children with Genetic Disorders
CONCLUSIONS: Despite more preoperative comorbidities, mid-term outcomes following heart transplant in children with genetic syndromes and disorders are promising.PMID:35007503 | DOI:10.1016/j.athoracsur.2021.12.019
Source: The Annals of Thoracic Surgery - January 10, 2022 Category: Cardiovascular & Thoracic Surgery Authors: Horacio G Carvajal Catherine Gooch Taylor C Merritt J Chancellor Fox Anne N Pourney Harshini D Kumaresan Matthew W Canter Pirooz Eghtesady Source Type: research

Hypothyroidism risk associated with rheumatoid arthritis: A population-based retrospective cohort study
Studies on the thyroid disease risk in patients with rheumatoid arthritis (RA) associated with comorbidities are limited. This population-based retrospective cohort study investigated the hypothyroidism risk in patients with RA and the role of comorbidities. We used Taiwan National Health Insurance Research Database to identify 16,714 RA patients newly diagnosed in 2000 to 2008 and 66,856 control persons without RA, frequency matched by sex, age, and index year. Incidence and the RA group to controls hazard ratio of hypothyroidism were estimated. The hypothyroidism incidence was 1.74-fold higher in the RA group than ...
Source: Medicine - January 7, 2022 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Janssen Data at ASCO GU Demonstrate Longstanding Leadership in Prostate Cancer and Commitment to Advancing Potential New Therapeutic Options for Genitourinary Cancers
Raritan, NJ, Feb. 1, 2022 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that 17 presentations will be featured at the 2022 American Society of Clinical Oncology Genitourinary (ASCO GU) Cancers Symposium, taking place in San Francisco and virtually from February 17-19. Building on its long-term leadership in prostate cancer, Janssen is committed to advancing innovative treatments and transforming patient experiences, while focusing on research that may drive better outcomes for people across the genitourinary cancer spectrum. Data to be presented include Phase 3 results for the selective ...
Source: Johnson and Johnson - February 1, 2022 Category: Pharmaceuticals Tags: Innovation Source Type: news

New ERLEADA ® (apalutamide) Analysis Demonstrates Rapid, Deep Prostate-Specific Antigen (PSA) Response in Patients with Metastatic Castration-Sensitive Prostate Cancer (mCSPC)
SAN FRANCISCO, Feb. 14, 2022 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced new real-world evidence data showing the initiation of ERLEADA® (apalutamide) results in high rates of rapid and deep prostate-specific antigen (PSA) response among patients with metastatic castration-sensitive prostate cancer (mCSPC). In a separate post-hoc analysis of the registrational Phase 3 SPARTAN and TITAN studies, rapid and deep PSA responses with ERLEADA® were associated with improvement in patient-reported outcomes (PROs) related to quality of life, physical wellbeing, pain, and fatigue intensity. The...
Source: Johnson and Johnson - February 14, 2022 Category: Pharmaceuticals Tags: Innovation Source Type: news

Case Report: Myxedema Coma Caused by Immunoglobulin A Vasculitis in a Patient With Severe Hypothyroidism
Myxedema coma is a critical disorder with high mortality rates. Disruption of the compensatory mechanism for severe and long-term hypothyroidism by various causes leads to critical conditions, including hypothermia, respiratory failure, circulatory failure, and central nervous system dysfunction. Infectious diseases, stroke, myocardial infarction, sedative drugs, and cold exposure are considered the main triggers for myxedema coma. A 59-year-old Japanese woman presented with bilateral painful purpura on her lower legs. She was diagnosed with coexisting immunoglobulin A (IgA) vasculitis and severe IgA vasculitis with nephri...
Source: Frontiers in Immunology - February 18, 2022 Category: Allergy & Immunology Source Type: research

Clinical code usage in UK general practice: a cohort study exploring 18 conditions over 14 years
Conclusions This is an under-reported research area and the findings suggest the codes’ usage diversity for most conditions remained overall stable throughout the study period. Generated mental health code lists can last for a long time unlike cardiometabolic conditions and cancer. Adopting more consistent and less diverse coding would help improve data quality in primary care. Future research is needed following the transfer to the Systematised Nomenclature of Medicine Clinical Terms (SNOMED CT) coding.
Source: BMJ Open - July 25, 2022 Category: General Medicine Authors: Zghebi, S. S., Reeves, D., Grigoroglou, C., McMillan, B., Ashcroft, D. M., Parisi, R., Kontopantelis, E. Tags: Open access, General practice / Family practice Source Type: research

Clinical outcomes in spontaneous coronary artery dissection
Conclusions In this large prospective cohort of patients with SCAD, prognosis was overall favourable, with events mainly driven by reinfarctions or unplanned revascularisations. History of hypothyroidism, proximal vessel involvement, type 2 IMH and DAPT at discharge were associated with MACCE. Trial registration number NCT03607981.
Source: Heart - September 12, 2022 Category: Cardiology Authors: Garcia-Guimaraes, M., Masotti, M., Sanz-Ruiz, R., Macaya, F., Roura, G., Nogales, J. M., Tizon-Marcos, H., Velazquez-Martin, M., Veiga, G., Flores-Rios, X., Abdul-Jawad Altisent, O., Jimenez-Kockar, M., Camacho-Freire, S., Moreu, J., Ojeda, S., Santos-Mar Tags: Coronary artery disease Source Type: research

Sex differences in major cardiovascular outcomes and fractures in patients with subclinical thyroid dysfunction: a systematic review and meta-analysis
CONCLUSIONS: There may be sex-related differences in the risks of MACE, any fracture, and hip fracture in patients with SH.PMID:36287183 | DOI:10.18632/aging.204352
Source: Aging - October 26, 2022 Category: Biomedical Science Authors: Hongjuan Fang Runsheng Zhao Shuang Cui Weiqing Wan Source Type: research