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Condition: Hypothyroidism
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Total 192 results found since Jan 2013.
Triiodothyronine Aggravates Global Cerebral Ischemia-Reperfusion Injury in Mice
In this study, we examined the effect of T3 administration on DNA fragmentation induced by neuronal death and the activation of inflammatory cells such as astrocytes and microglia in the hippocampus following GCI. The content of nucleosomes generated by DNA fragmentation in the hippocampus was increased by GCI and further increased by T3 administration. The protein expression levels of glial fibrillary acidic protein (GFAP), an astrocytic marker, and Ionized calcium binding adaptor protein 1 (Iba1), a microglial marker, in the hippocampus were also increased by GCI and further increased by T3 administration. The levels of ...
Source: Biological and Pharmaceutical Bulletin - December 2, 2021 Category: Drugs & Pharmacology Authors: Masaru Doshi Shiro Watanabe Yujin Natori Makoto Hosoyamada Yutaka Hirashima-Akae Source Type: research
Fatal Adverse Events of Dabigatran Combined With Aspirin in Elderly Patients: An Analysis Using Data From VigiBase
Conclusion: The fatal adverse events associated with the combined use of dabigatran and aspirin in elderly patients were mainly serious bleeding events, which often occurred within 1 month. Most of these cases had medication errors and most of the patients had multiple diseases, medications, or other conditions at the same time that increase the risk of bleeding. It is suggested that prescription of dabigatran and aspirin in elderly patients should go along with alertness for medication errors, care for correct dose or control of other bleeding risk factors, and the combined medication time should be as short as possible ...
Source: Frontiers in Pharmacology - December 22, 2021 Category: Drugs & Pharmacology Source Type: research
Triiodothyronine Aggravates Global Cerebral Ischemia-Reperfusion Injury in Mice
In this study, we examined the effect of T3 administration on DNA fragmentation induced by neuronal death and the activation of inflammatory cells such as astrocytes and microglia in the hippocampus following GCI. The content of nucleosomes generated by DNA fragmentation in the hippocampus was increased by GCI and further increased by T3 administration. The protein expression levels of glial fibrillary acidic protein (GFAP), an astrocytic marker, and Ionized calcium binding adaptor protein 1 (Iba1), a microglial marker, in the hippocampus were also increased by GCI and further increased by T3 administration. The levels of ...
Source: Biological and Pharmaceutical Bulletin - December 2, 2021 Category: Drugs & Pharmacology Authors: Masaru Doshi Shiro Watanabe Yujin Natori Makoto Hosoyamada Yutaka Hirashima-Akae Source Type: research
