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Condition: Lupus

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Total 491 results found since Jan 2013.

Antiphospholipid Syndrome Diagnosed as a Result of the Occurrence of an Ischemic Stroke After a Successful Catheter Ablation of Atrial Fibrillation and Continuous Direct Oral Anticoagulants
We report a case of an ischemic stroke after a successful catheter ablation of atrial fibrillation (AF) and continuous oral anticoagulation therapy with direct oral anticoagulants (DOACs), which was the trigger for diagnosing antiphospholipid syndrome (APS). A 68-year-old woman underwent catheter ablation of persistent AF and continued oral anticoagulation with edoxaban at a dose of 30 mg once daily after the ablation procedure. An asymptomatic intracerebral hemorrhage was detected by brain computed tomography and magnetic resonance imaging one month post-ablation. Oral anticoagulation with dabigatran at 110 mg twice daily...
Source: International Heart Journal - January 31, 2022 Category: Cardiology Authors: Yumiko Haraguchi Kohki Nakamura Mitsuho Inoue Takehito Sasaki Kentaro Minami Shingo Yoshimura Shigeto Naito Source Type: research

Lupus, antiphospholipid syndrome, and stroke: An attempt to crossmatch
Lupus. 2023 Mar 20:9612033231165151. doi: 10.1177/09612033231165151. Online ahead of print.ABSTRACTCerebrovascular accidents (CVAs) or strokes are part of the common thrombotic manifestations of Systemic Lupus Erythematosus (SLEs) and Antiphospholipid syndrome (APS). Such neurological thrombotic events tend to occur in patients with SLE at a higher frequency when Antiphospholipid antibodies (aPLs) are present, and tend to involve the large cerebral vessels. The mechanism of stroke in SLE can be driven by complement deposition and neuroinflammation involving the blood-brain barrier although the traditional cardiovascular ri...
Source: Lupus - March 20, 2023 Category: Rheumatology Authors: Georges El Hasbani Imad Uthman Source Type: research

Multiple presence of prothrombotic risk factors in Croatian children with arterial ischemic stroke and transient ischemic attack.
Conclusion. The presence of multiple prothrombotic risk factors in children with cerebrovascular disorder suggests that a combination of risk factors rather than individual risk factors could contribute to cerebrovascular disorders in children. PMID: 23986275 [PubMed - in process]
Source: Croatian Medical Journal - August 28, 2013 Category: Journals (General) Authors: Lenicek Krleza J, Duranovic V, Bronic A, Coen Herak D, Mejaski-Bosnjak V, Zadro R Tags: Croat Med J Source Type: research

CNS vasculitis and stroke in neonatal lupus erythematosus: A case report and review of literature.
We describe a 2-months-old girl who presented with acute ischemic stroke secondary to central nervous system vasculitis without any cardiac, cutaneous or hematological manifestations. The mother was pauci-symptomatic with raised anti-Ro autoantibody titers; the baby was positive for autoantibodies against Ro-antigen. Angiography confirmed vasculitis in cerebral vasculature. Our case highlights that neonatal lupus erythematosus can present with isolated nervous system manifestations and the vascular damage can be permanent in the form of vasculitis. Early recognition will help pediatricians identify such possible permanent ...
Source: European Journal of Paediatric Neurology - January 25, 2014 Category: Neurology Authors: Saini AG, Sankhyan N, Bhattad S, Vyas S, Saikia B, Singhi P Tags: Eur J Paediatr Neurol Source Type: research

Thrombophilia in Young Patients with Cerebrovascular Disease. AISYF Study (S55.005)
Conclusion: Our study showed alterations in 17/125(14%) patients with arterial CVA, excluded PAI abnormalities.With the exception of antiphospholipid antibodies the value of testing TF as part of the evaluation of patients with arterial CVA, even in patients with a cryptogenic event,is still controversial and should not lead to anticoagulation of all these patients.Study Supported by Shire HGTDisclosure: Dr. Leon Cejas has nothing to disclose. Dr. Reisin has received personal compensation for activities with Shire Pharmaceuticals Group. Dr. Reisin has received personal compensation in an editorial capacity for Neurology. D...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Leon Cejas, L., Reisin, R. Tags: Pediatric Stroke and Stroke in the Young Source Type: research

Antiphospholipid antibodies in neonates with stroke--a unique entity or variant of antiphospholipid syndrome?
ConclusionsThe presence of aPL may be important in the pathogenesis of cerebral thrombosis in neonates. Nevertheless, the nature of thrombophilia interactions in this period and their therapeutic impact warrants further investigation. PMID: 24729280 [PubMed - as supplied by publisher]
Source: Lupus - April 11, 2014 Category: Rheumatology Authors: Berkun Y, Simchen M, Strauss T, Menashcu S, Padeh S, Kenet G Tags: Lupus Source Type: research

GLUTAMATE RECEPTOR ANTIBODIES IN NEUROLOGICAL DISEASES: Anti-AMPA-GluR3 antibodies, Anti-NMDA-NR1 antibodies, Anti-NMDA-NR2A/B antibodies, Anti-mGluR1 antibodies or Anti-mGluR5 antibodies are present in subpopulations of patients with either: Epilepsy, Encephalitis, Cerebellar Ataxia, Systemic Lupus Erythematosus (SLE) and Neuropsychiatric SLE, Sjogren's syndrome, Schizophrenia, Mania or Stroke. These autoimmune anti-glutamate receptor antibodies can bind neurons in few brain regions, activate glutamate receptors, decrease glutamate receptor's expression, impair glutamate-induced signaling and function, activate Blood Brain Barrier endothelial cells, kill neurons, damage the brain, induce behavioral/psychiatric/cognitive abnormalities and Ataxia in animal models, and can be removed or silenced in some patients by immunotherapy.
Abstract Glutamate is the major excitatory neurotransmitter of the Central Nervous System (CNS), and it is crucially needed for numerous key neuronal functions. Yet, excess glutamate causes massive neuronal death and brain damage by excitotoxicity-detrimental over activation of glutamate receptors. Glutamate-mediated excitotoxicity is the main pathological process taking place in many types of acute and chronic CNS diseases and injuries. In recent years, it became clear that not only excess glutamate can cause massive brain damage, but that several types of anti-glutamate receptor antibodies, that are present in ...
Source: Herpes - August 1, 2014 Category: Infectious Diseases Authors: Levite M Tags: J Neural Transm Source Type: research

The risk of ischemic stroke in major rheumatic disorders
Rheumatic disorders (RD) are a range of conditions associated with inflammation of joints and connective tissue. They can manifest beyond the musculoskeletal system. Recent focus has been placed on the association of ischemic stroke with these conditions. Traditional vascular risk factors seem to be more prevalent in patients with certain types of RD than in the general population, but these factors do not fully explain the enhanced vascular risk in this population. Four major RD will be discussed in terms of their relationship with ischemic stroke: rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis...
Source: Journal of Neuroimmunology - September 20, 2014 Category: Allergy & Immunology Authors: Réza Behrouz Tags: Review article Source Type: research

Stroke in a Case of Neonatal Lupus: An Uncommon Complication
We report a 2-year-old girl with congenital complete heart block who presented with acute-onset right middle cerebral artery territory stroke. The congenital heart block was secondary to maternal lupus.
Source: Journal of Child Neurology - October 30, 2014 Category: Neurology Authors: Suthar, R., Sahu, J. K., Rohit, M., Khandelwal, N. K., Singhi, P. Tags: Brief Communication (E-Only) Source Type: research

Hypercoagulability and the risk of myocardial infarction and ischemic stroke in young women.
CONCLUSION: In young women, prothrombotic factors are more associated with risk of IS than MI risk, suggesting a different role of hypercoagulability in the mechanism leading to these two diseases. This article is protected by copyright. All rights reserved. PMID: 26178535 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - July 14, 2015 Category: Hematology Authors: Siegerink B, Maino A, Algra A, Rosendaal FR Tags: J Thromb Haemost Source Type: research

Non-stroke Central Neurologic Manifestations in Antiphospholipid Syndrome
Abstract Thrombotic manifestations of antiphospholipid syndrome (APS) are well known, and various non-stroke neuro-psychiatric manifestations (NPMs) have also been consistently described, but their place in APS remains unclear. Some syndromes, such as migraine or cognitive dysfunction, are frequently described in APS, whereas others, like seizure, multiple sclerosis-like symptoms, transverse myelitis, movement disorders, or psychiatric symptoms, are rarely found. Overlap with other autoimmune diseases, in particular with systemic lupus erythematosus, the lack of large sample size prospective studies, and discrepa...
Source: Current Rheumatology Reports - February 29, 2016 Category: Rheumatology Source Type: research

Successful intravenous thrombolysis in a patient with antiphospholipid syndrome, acute ischemic stroke and severe thrombocytopenia
Alteplase is the only approved drug for the treatment of acute ischemic stroke, but it is offered to a minority of patients, not only because of the short therapeutic window but also because of the numerous contraindications associated with thrombolysis, such as thrombocytopenia. There is some controversy on the true risk associated with thrombolysis in patients with thrombocytopenia. Here we report the case of a young patient, who developed an in-hospital acute ischemic stroke involving a large territory of the right middle cerebral artery, who was successfully treated with intravenous alteplase, despite having thrombocyt...
Source: Blood Coagulation and Fibrinolysis - March 31, 2016 Category: Hematology Tags: Case Reports Source Type: research

Detection of multiple annexin autoantibodies in a patient with recurrent miscarriages, fulminant stroke and seronegative antiphospholipid syndrome.
Authors: Scholz P, Auler M, Brachvogel B, Benzing T, Mallman P, Streichert T, Klatt AR Abstract Anti-phospholipid syndrome (APS) is one of the main causes for recurrent miscarriages. The diagnosis of APS is based on the occurrence of clinical symptoms such as thrombotic events or obstetric complications as well as the detection of antiphospholipid antibodies directed against β2-glycoprotein I and cardiolipin, or a positive lupus anticoagulant assay. However, there is a subpopulation of patients with clinical symptoms of APS, but the lack of serological markers (seronegative APS). In addition, a large proportion of...
Source: Biochemia Medica - June 29, 2016 Category: Biochemistry Tags: Biochem Med (Zagreb) Source Type: research

Carotid free-floating thrombus causing stroke in a young woman with lupus anticoagulant: A case report and review of the literature
Conclusion In this case we chose surgical treatment resulting in complete resolution of symptoms and non-recurrence within 6 month follow-up.
Source: International Journal of Surgery Case Reports - February 20, 2017 Category: Surgery Source Type: research

Stroke is Different in Systemic Lupus Erythematosus: Implications for Survival and Functionality
J Rheumatol. 2021 Mar 1:jrheum.201209. doi: 10.3899/jrheum.201209. Online ahead of print.ABSTRACTUndoubtedly, individuals with systemic lupus erythematosus (SLE) are at higher risk for developing cerebrovascular disease than counterparts from the general population without SLE. In a metaanalysis of studies from around the world, the likelihood of individuals with SLE developing both ischemic and hemorrhagic stroke (intracerebral and/or subarachnoid hemorrhage) was more than 2 times that of the general population1 Risks for stroke appear to be highest soon after SLE diagnosis, and concomitant antiphospholipid syndrome (APS)...
Source: Journal of Rheumatology - March 2, 2021 Category: Rheumatology Authors: Marios Rossides Source Type: research