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Condition: Lupus

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Total 491 results found since Jan 2013.

Antiphospholipid Antibodies and the Risk of Stroke in Urban and Rural Tanzania: A Community-Based Case-Control Study Clinical Sciences
Conclusions— The presence of lupus anticoagulant is a strong, and to date unrecognized, risk factor for stroke in Tanzania, especially in young and middle-aged individuals.
Source: Stroke - September 25, 2016 Category: Neurology Authors: de Mast, Q., Molhoek, J. E., van der Ven, A. J., Gray, W. K., de Groot, P. G., Jusabani, A., Mugusi, F., Urbanus, R. T., Walker, R. W. Tags: Etiology, Mechanisms, Pathophysiology, Cerebrovascular Disease/Stroke, Ischemic Stroke Clinical Sciences Source Type: research

Cerebrovascular Disease in Rheumatic Diseases: A Systematic Review and Meta-Analysis Clinical Sciences
Conclusions— Risk of any stroke is higher in most rheumatic diseases than in the general population, particularly <50 years. Rheumatoid arthritis and systemic lupus erythematosus increase ischemic and hemorrhagic stroke risk by 60% to 100% relative to the general population.
Source: Stroke - March 27, 2016 Category: Neurology Authors: Wiseman, S. J., Ralston, S. H., Wardlaw, J. M. Tags: Imaging, Cerebrovascular Disease/Stroke, Ischemic Stroke Clinical Sciences Source Type: research

Incidence of Ischemic Stroke in Young Adults, a 4 Year Retrospective Review from an Urban Tertiary Care Center in North Philadelphia (P3.232)
Conclusions: The incidence of Ischemic Stroke in this cohort is much higher than that reported in other observational studies. Despite an extensive work up, a cause was not found in the majority of patients. These data support the need for a more in depth investigation of the causes of stroke in the young in urban, underserved communities. Standard of care diagnostic tests fail to explain the unusually high incidence of Ischemic Stroke in this cohort.Disclosure: Dr. Pirastehfar has nothing to disclose. Dr. Katz has nothing to disclose. Dr. Gentile has nothing to disclose. Dr. Jacobi has nothing to disclose. Dr. Linares has...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Pirastehfar, M., Katz, P., Gentile, N., Jacobi, J., Linares, G. Tags: Stroke in the Young Source Type: research

Cerebral Small Vessel Disease Burden Is Increased in Systemic Lupus Erythematosus Clinical Sciences
This study aimed to determine the association between SLE and features on neuroimaging of cerebral small vessel disease (SVD), a risk factor for stroke.Methods—Consecutive patients attending a clinic for SLE were recruited. All patients underwent brain magnetic resonance imaging; had blood samples taken for markers of inflammation, endothelial dysfunction, cholesterol, and autoantibodies; and underwent cognitive and psychiatric testing. The data were compared with sex- and age-matched healthy controls and patients with minor stroke. Features of SVD were measured, a total SVD score calculated, and associations sought with...
Source: Stroke - October 23, 2016 Category: Neurology Authors: Wiseman, S. J., Bastin, M. E., Jardine, C. L., Barclay, G., Hamilton, I. F., Sandeman, E., Hunt, D., Amft, E. N., Thomson, S., Belch, J. F. F., Ralston, S. H., Wardlaw, J. M. Tags: Risk Factors, Imaging, Ischemic Stroke Original Contributions Source Type: research

Numerous Fusiform and Saccular Cerebral Aneurysms in Central Nervous System Lupus Presenting with Ischemic Stroke
We report a patient with an active SLE flare who presented with a recurrent ischemic stroke and was found to have numerous unruptured fusiform and saccular aneurysms in multiple vascular territories. He was treated with high-dose steroid and rituximab along with aspirin and blood pressure control for stroke prevention.
Source: Journal of Stroke and Cerebrovascular Diseases - May 4, 2017 Category: Neurology Authors: Shahram Majidi, Christopher R. Leon Guerrero, Shreya Gandhy, Kathleen M. Burger, Dimitri Sigounas Tags: Case Studies Source Type: research

Failure of Anticoagulation to Prevent Stroke in Context of Lupus-Associated Anti-Phospholipid Syndrome and Mild COVID-19
We present a 43-year-old female with a history of seropositive-antiphospholipid syndrome and systemic lupus erythematosus who developed an acute ischemic stroke in the setting of mild COVID-19 infection despite adherence to chronic systemic anticoagulation.
Source: Journal of Stroke and Cerebrovascular Diseases - April 12, 2021 Category: Neurology Authors: Keith J. Kincaid, Alexis N. Simpkins Source Type: research

A Genetic Variant of miR-34a Contributes to Susceptibility of Ischemic Stroke Among Chinese Population
This study was supported by National Natural Science Foundation of China (Nos. 81560552, 81260234), Natural Science Foundation of Guangxi Zhuang Autonomous Region (CN) (2017JJA180826), Innovation Project of Guangxi Graduate Education (CN) (201601009) and Key Laboratory Open Project Fund of Guangxi Zhuang Autonomous Region (CN) (kfkt20160064). Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Supplementary Material The Supplementary Material for this article can be fou...
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research

Stroke in Non-Bacterial Thrombotic Endocarditis: 31-Year Experience (P02.023)
CONCLUSIONS: This 31-year analysis shows that stroke is a frequent complication of NBTE, has severe clinical and radiological manifestations, and high associated mortality. Anticoagulation may not prevent stroke recurrence.Disclosure: Dr. Topcuoglu has nothing to disclose. Dr. Kursun has nothing to disclose. Dr. Karatas has nothing to disclose. Dr. Buonanno has nothing to disclose. Dr. Singhal has received personal compensation as an expert witness in medicolegal cases involving stroke in young adults. Dr. Singhal's wife is an employee of Vertex Pharmaceuticals, Inc. Dr. Singhal has received research support from Pfizer and Photothera, Inc.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Topcuoglu, M., Kursun, O., Karatas, H., Buonanno, F., Singhal, A. Tags: P02 Cerebrovascular Disease II Source Type: research

Imaging pattern and outcome of stroke in patients with systemic lupus erythematosus: a case-control study.
CONCLUSION: Stroke in SLE patients is associated with a poorer outcome than matched controls in terms of functional recovery, recurrence and mortality. PMID: 33259330 [PubMed - as supplied by publisher]
Source: Journal of Rheumatology - December 2, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

Heterogeneity of Stroke in Patients with Systemic Lupus Erythematosus
Conclusion The contributions of SLE to stroke varied significantly according to the stroke subtype. Given the unfavorable prognosis, close stroke subtype-specific observation by rheumatologists and stroke specialists is recommended after stroke events.PMID:36244734 | DOI:10.2169/internalmedicine.9228-21
Source: Atherosclerosis - October 16, 2022 Category: Cardiology Authors: Takaya Kitano Toru Hirano Shuhei Okazaki Eri Itotagawa Yoshiki Yagita Yoshitaka Morita Akihiro Watanabe Daisuke Takahashi Manabu Sakaguchi Hiroshi Fujiwara Kenichi Todo Tsutomu Sasaki Atsushi Kumanogoh Hideki Mochizuki Source Type: research

Long-Term Anticoagulation in Secondary Ischemic Stroke Prevention: The Prospective Multicenter RESTAIC Registry
Conclusion: Long-term OAC in secondary stroke prevention is associated with a lower frequency of bleeding complications than stroke recurrences. No differences between anticoagulant drugs were found in any of the analyzed outcomes. The main cause for OAC switch during follow-up was stroke recurrence.
Source: Frontiers in Neurology - October 19, 2020 Category: Neurology Source Type: research