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Condition: Metabolic Syndrome

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Total 926 results found since Jan 2013.

Sex differences in neuroinflammation and neuroprotection in ischemic stroke.
Abstract Stroke is not only a leading cause of mortality and morbidity worldwide it also disproportionally affects women. There are currently over 500,000 more women stroke survivors in the US than men, and elderly women bear the brunt of stroke-related disability. Stroke has dropped to the fifth leading cause of death in men, but remains the third in women. This review discusses sex differences in common stroke risk factors, the efficacy of stroke prevention therapies, acute treatment responses, and post-stroke recovery in clinical populations. Women have an increased lifetime risk of stroke compared to men, larg...
Source: Cell Research - November 23, 2016 Category: Cytology Authors: Spychala MS, Honarpisheh P, McCullough LD Tags: J Neurosci Res Source Type: research

Serum fatty acid binding protein 4 is positively associated with early stroke recurrence in nondiabetic ischemic stroke.
This study included the 206 acute ischemic stroke patients hospitalized in our institution. Stroke recurrence events were assessed at the 3-month follow-up. The median of FABP level was 22.6 (IQR, 17.9-31.6) ng/mL in patients with stroke recurrence (N=36), which was higher than in patients without stroke recurrence [16.9 (IQR, 11.8-21.4) ng/mL] (P<0.001). As a continuous variable, the unadjusted and adjusted risk of stroke recurrence would be increased by 12% (OR=1.12 [95% CI 1.06-1.17], P<0.001) and 8% (1.08 [1.02-1.14], P=0.006) for every 1 ng/ml increment of FABP4. The Area under the curve (AUC) of serum FABP4 and...
Source: Aging - April 8, 2019 Category: Biomedical Science Authors: Li B, Wu J, Jiang P, Li M, Liu Q, Cao Y, Wang S Tags: Aging (Albany NY) Source Type: research

Sex differences in neuroinflammation and neuroprotection in ischemic stroke
Stroke is not only a leading cause of mortality and morbidity worldwide it also disproportionally affects women. There are currently over 500,000 more women stroke survivors in the US than men, and elderly women bear the brunt of stroke‐related disability. Stroke has dropped to the fifth leading cause of death in men, but remains the third in women. This review discusses sex differences in common stroke risk factors, the efficacy of stroke prevention therapies, acute treatment responses, and post‐stroke recovery in clinical populations. Women have an increased lifetime risk of stroke compared to men, largely due to a s...
Source: Journal of Neuroscience Research - November 6, 2016 Category: Neuroscience Authors: Monica S. Spychala, Pedram Honarpisheh, Louise D. McCullough Tags: Review Source Type: research

Neuroprotective Effect of Pre-Stroke Statin Therapy in a Cohort of Elderly Ischemic Stroke Patients (P03.195)
CONCLUSIONS: Pre-stroke statin treatment is strongly associated with improved functionality and cognition in elderly patients. Mortality and recurrence rates were similar in all patients, independently of pre-stroke statin treatment.Disclosure: Dr. Alonzo has nothing to disclose. Dr. Ramirez Campos has nothing to disclose. Dr. Brescacin has nothing to disclose. Dr. Ramirez Campos has nothing to disclose. Dr. Camera has nothing to disclose. Dr. Waisman has nothing to disclose. Dr. Cristiano has received personal compensation for activities with Bayer, Biogen Idec, Merck & Co., Inc., and Novartis.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Alonzo, C., Zurru, M., Brescacin, L., Ramirez Campos, V., Camera, L., Waisman, G., Cristiano, E. Tags: P03 Cerebrovascular Disease III Source Type: research

Peripheral biomarkers of stroke: Focus on circulatory microRNAs
This article also reviews research investigating circulatory miRNAs as peripheral biomarkers of stroke.
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - August 9, 2016 Category: Molecular Biology Source Type: research

Hypertension and Diabetes Mellitus as a Predictive Risk Factors for Stroke
Conclusion after summarising all the studies mentioned in the paper, it can be established that hypertension and diabetes mellitus are a stroke risk factors and correlated in patients with atherosclerosis.
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - March 19, 2018 Category: Endocrinology Source Type: research

A Combination of Atorvastatin and Aspirin Enhances the Pro-Regenerative Interactions of Marrow Stromal Cells and Stroke-Derived Monocytes In Vitro
Conclusion: Atorvastatin, alone and in combination with aspirin can promote anti-inflammatory effect by modulating the secretome profile of Mo and MSCs. Our results suggest that stroke trials involving the use of intravenous MSCs should consider the effect of aspirin and atorvastatin, both of which are administered to the majority of hospitalized ischemic stroke patients.
Source: Frontiers in Pharmacology - April 20, 2021 Category: Drugs & Pharmacology Source Type: research

Obstructive Sleep Apnea and Stroke: Determining the Mechanisms Behind their Association and Treatment Options
Transl Stroke Res. 2023 Mar 16. doi: 10.1007/s12975-023-01123-x. Online ahead of print.ABSTRACTSleep-disordered breathing (SDB) can be a sequela of stroke caused by vascular injury to vital respiratory centers, cerebral edema, and increased intracranial pressure of space-occupying lesions. Likewise, obstructive sleep apnea (OSA) contributes to increased stroke risk through local mechanisms such as impaired ischemic cerebrovascular response and systemic effects such as promoting atherosclerosis, hypercoagulability, cardiac arrhythmias, vascular-endothelial dysfunction, and metabolic syndrome. The impact of OSA on stroke out...
Source: Atherosclerosis - March 16, 2023 Category: Cardiology Authors: Basma Mohamed Keerthi Yarlagadda Zachary Self Alexandra Simon Frank Rigueiro Maryam Sohooli Stephan Eisenschenk Sylvain Dor é Source Type: research

Immune-inflammatory markers and arterial stiffness indexes in subjects with acute ischemic stroke with and without metabolic syndrome
Conclusions: Stroke subjects with acute ischemic stroke and metabolic syndrome showed a higher degree of immuno-inflammatory and arterial stiffness indexes possibly due to metabolic background of these types of patients that trigger a more intense immune-inflammatory activation irrespective of stroke subtype, whereas being related to stroke subtype in subjects without metabolic syndrome.
Source: Epidemiologic Perspectives and Innovations - February 27, 2014 Category: Epidemiology Authors: Antonino TuttolomondoRosaria PecoraroDomenico Di RaimondoRiccardo Di SciaccaBaldassare CaninoValentina ArnaoCarmelo ButtàVittoriano Della CorteCarlo MaidaGiuseppe LicataAntonio Pinto Source Type: research

Metabolic Syndrome and Ischemic Stroke Risk by Sex: Meta-analysis (I12-2B)
CONCLUSIONS: The metabolic syndrome is prevalent, and a significant risk factor for ischemic stroke with differential effects by sex. Women with metabolic syndrome had a near 2 folds higher stroke risk than men with metabolic syndrome. Future studies are needed to elucidate the mechanism by which the metabolic syndrome exerts higher stroke burden on women.Disclosure: Dr. Lin has nothing to disclose. Dr. Saposnik has nothing to disclose. Dr. Shi has nothing to disclose. Dr. Towfighi has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Lin, M., Saposnik, G., Shi, Q., Towfighi, A. Tags: Obesity and Neurological Disorders Data Blitz Presentations Source Type: research

Metabolic Syndrome and Ischemic Stroke Risk by Sex: Meta-analysis (P1.004)
CONCLUSIONS: The metabolic syndrome is prevalent, and a significant risk factor for ischemic stroke with differential effects by sex. Women with metabolic syndrome had a near 2 folds higher stroke risk than men with metabolic syndrome. Future studies are needed to elucidate the mechanism by which the metabolic syndrome exerts higher stroke burden on women.Disclosure: Dr. Lin has nothing to disclose. Dr. Saposnik has nothing to disclose. Dr. Shi has nothing to disclose. Dr. Towfighi has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Lin, M., Saposnik, G., Shi, Q., Towfighi, A. Tags: Cerebrovascular Disease and Interventional Neurology Poster Discussion Session Source Type: research

Correlation between CH2DS2-VASc Score and Serum Leptin Levels in Cardioembolic Stroke Patients: The Impact of Metabolic Syndrome.
Conclusion: This pilot study revealed that leptin could be a potential biomarker for risk stratification of cardioembolic stroke in MetS patients and that heterogeneity of stroke subtypes should be considered for more refined and precise clinical stroke studies. PMID: 29225622 [PubMed]
Source: International Journal of Endocrinology - December 13, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Hypertension and diabetes mellitus as a predictive risk factors for stroke
Conclusionafter summarising all the studies mentioned in the paper, it can be established that hypertension and diabetes mellitus are a stroke risk factors and correlated in patients with atherosclerosis.
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - July 23, 2018 Category: Endocrinology Source Type: research

Visceral Adiposity and Risk of Stroke: A Mendelian Randomization Study
ConclusionsThis study provides potential evidence for a causal role of VAT in ischemic stroke and could suggest novel genetical therapeutic strategies for distinct subtypes of ischemic stroke.
Source: Frontiers in Neurology - April 11, 2022 Category: Neurology Source Type: research

Elevated Chinese visceral adiposity index increases the risk of stroke in Chinese patients with metabolic syndrome
ConclusionOur findings recommend CVAI as a superior screening tool for detecting MetS and suggest that reducing CVAI can mitigate the risk of stroke in patients with MetS.
Source: Frontiers in Endocrinology - June 29, 2023 Category: Endocrinology Source Type: research