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Condition: Metabolic Syndrome

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Total 926 results found since Jan 2013.

The role of uric acid in the pathogenesis of human cardiovascular disease
Hyperuricaemia is common in subjects with cardiovascular disease, but is not commonly considered a true risk factor. Recent studies suggest that uric acid is biologically active and can stimulate oxidative stress, endothelial dysfunction, inflammation and vasoconstriction. Epidemiological studies have found that uric acid can independently predict the development of hypertension, as well as stroke and heart failure. Experimentally raising uric acid in animals increases blood pressure, and pilot studies suggest that lowering uric acid in humans can reduce blood pressure in hypertensive individuals. Uric acid may also have e...
Source: Heart - May 1, 2013 Category: Cardiology Authors: Kanbay, M., Segal, M., Afsar, B., Kang, D.-H., Rodriguez-Iturbe, B., Johnson, R. J. Tags: Reviews Source Type: research

Chronic obstructive pulmonary disease.
Abstract The global prevalence of physiologically defined chronic obstructive pulmonary disease (COPD) in adults aged >40 yr is approximately 9-10 per cent. Recently, the Indian Study on Epidemiology of Asthma, Respiratory Symptoms and Chronic Bronchitis in Adults had shown that the overall prevalence of chronic bronchitis in adults >35 yr is 3.49 per cent. The development of COPD is multifactorial and the risk factors of COPD include genetic and environmental factors. Pathological changes in COPD are observed in central airways, small airways and alveolar space. The proposed pathogenesis of COPD includes pr...
Source: The Indian Journal of Medical Research - February 1, 2013 Category: Biomedical Science Authors: Vijayan VK Tags: Indian J Med Res Source Type: research

Increased prevalence of metabolic syndrome among hypertensive population: Ten years' trend of the Korean National Health and Nutrition Examination Survey
Conclusion: MetS prevalence among hypertensives was much higher than expected. Moreover, MetS increased target organ damage in hypertensives. Investigation of metabolic status when initiating hypertension control could help establish more effective overall risk control.
Source: International Journal of Cardiology - December 22, 2011 Category: Cardiology Authors: So-Ryoung Lee, Myung-Jin Cha, Do-Yoon Kang, Kyu-Chul Oh, Dong-Ho Shin, Hae-Young Lee Tags: Original Articles Source Type: research

Insulin Resistance, Small LDL Particles, and Risk for Atherosclerotic Disease.
Abstract There is a global epidemic of obesity, metabolic syndrome, and diabetes mellitus. Insulin resistance (IR) is etiologic for both metabolic syndrome and diabetes mellitus. IR induces a broad range of toxic systemic effects, including dyslipidemia, hypertension, hyperglycemia, increased production of advanced glycosylation end products, increased inflammatory tone, as well as a prothrombotic and pro-oxidative state. Patients with IR are highly vulnerable to the development of accelerated atherosclerosis as well its clinical sequelae, including coronary artery disease and myocardial infarction, carotid artery...
Source: Current Vascular Pharmacology - April 25, 2013 Category: Drugs & Pharmacology Authors: Toth PP Tags: Curr Vasc Pharmacol Source Type: research

Clinical correlates of obesity in an inner-city adult medicine clinic.
In conclusion, obesity was associated with many diseases, as well as with healthcare utilization, unemployment and disability in this predominantly minority inner-city population. PMID: 23691735 [PubMed - in process]
Source: Connecticut Medicine - April 1, 2013 Category: Journals (General) Authors: Yassir S, Chopra R, Roush G Tags: Conn Med Source Type: research

Prevalence of the metabolic syndrome in the old institutionalized people in Zagreb, Croatia.
Abstract Metabolic syndrome (MeS) is defined by a cluster of abnormalities comprising obesity, hypertension, carbohydrate intolerance and dyslipidemia. MeS increases the risk of developing various diseases, including coronary heart disease, stroke, peripheral angiopathy and type 2 diabetes. In our study, the subjects were 561 persons, residents of 11 homes for the elderly in Zagreb, Croatia. There were 160 men (28.5%) and 401 women (71.5%), aged from 56 to 96 years (the average being 79 years). Physical examination was conducted, which included blood pressure measurement, and body height and weight. Blood samples ...
Source: Collegium Antropologicum - March 1, 2013 Category: Epidemiology Authors: Nevajda B, Havelka-Mestrović A, Bilić M, Nevajda AP, Romić D, Vuletić V, Cukljek S, Sicaja M, Bocina Z Tags: Coll Antropol Source Type: research

No evidence Nordic diet prevents heart disease
Conclusion This was a well-designed randomised controlled trial that took place across several Nordic locations. The study took careful clinical measures of elements of metabolic syndrome at several points during the trial, and used food diaries at regular intervals to check compliance to the assigned diet. However, it provides no reliable proof that the ‘healthy’ Nordic diet is any better than the ‘average’ Nordic diet at improving components of metabolic syndrome and, in turn, no proof that it reduces the risk of cardiovascular disease. Importantly, this study found no significant results for its main aim (which...
Source: NHS News Feed - May 31, 2013 Category: Consumer Health News Tags: Food/diet Lifestyle/exercise Heart/lungs Source Type: news

Got Bipolar? You're at Risk for Metabolic Syndrome, Too
A study found that people with bipolar disorder are up to twice as likely as the general population to have metabolic syndrome, a cluster of symptoms that increase your risk of heart problems, stroke and diabetes. The study, published in the Journal of Affective Disorders, also found that "co-occurrence of metabolic syndrome in the bipolar population is associated with a more complex illness presentation, less favorable response to treatment, and adverse course and outcome." In other words, for people with bipolar disorder, both are likely to be more serious and harder to treat. Why are people with bipolar more likely to ...
Source: About.com Bipolar Disorder - June 3, 2013 Category: Psychiatry Source Type: news

The world pandemic of vitamin D deficiency could possibly be explained by cellular inflammatory response activity induced by the renin-angiotensin system
This review attempts to show that there may be a relationship between inflammatory processes induced by chronic overstimulation of the renin-angiotensin system (RAS) and the worldwide deficiency of vitamin D (VitD) and that both disorders are probably associated with environmental factors. Low VitD levels represent a risk factor for several apparently different diseases, such as infectious, autoimmune, neurodegenerative, and cardiovascular diseases, as well as diabetes, osteoporosis, and cancer. Moreover, VitD insufficiency seems to predispose to hypertension, metabolic syndrome, left ventricular hypertrophy, heart failure...
Source: AJP: Cell Physiology - June 1, 2013 Category: Cytology Authors: Ferder, M., Inserra, F., Manucha, W., Ferder, L. Tags: REVIEW Source Type: research

Should visceral fat be reduced to increase longevity?
Abstract Several epidemiologic studies have implicated visceral fat as a major risk factor for insulin resistance, type 2 diabetes mellitus, cardiovascular disease, stroke, metabolic syndrome and death. Utilizing novel models of visceral obesity, numerous studies have demonstrated that the relationship between visceral fat and longevity is causal while the accrual of subcutaneous fat does not appear to play an important role in the etiology of disease risk. Specific recommended intake levels vary based on a number of factors, including current weight, activity levels, and weight loss goals. It is discussed the nee...
Source: Ageing Research Reviews - June 10, 2013 Category: Genetics & Stem Cells Authors: Finelli C, Sommella L, Gioia S, La Sala N, Tarantino G Tags: Ageing Res Rev Source Type: research

Early Diagnosis Of The Metabolic Syndrome Can Trigger Preventive Treatment Sooner, Before Type 2 Diabetes Develops
Researchers have developed a risk assessment scoring system that they believe may better identify certain adults - especially African Americans - at high risk of developing type 2 diabetes, heart disease and stroke than does the current system of diagnosing the metabolic syndrome. The results were presented at The Endocrine Society's 95th Annual Meeting in San Francisco...
Source: Health News from Medical News Today - June 20, 2013 Category: Consumer Health News Tags: Diabetes Source Type: news

Just a few extra pounds increases heart failure risk
Conclusion This large study uses an interesting genetic approach (Mendelian randomisation) to suggest obesity increases the risk of heart failure and adverse changes in liver enzymes. The combination of a very large sample, prospectively collected information, and a wide range of cardiometabolic measures lend credibility to the findings. The method the researchers used is also thought to reduce the chances of factors other than BMI influencing results, and the chance that the ‘outcome’ could be causing the ‘exposure’ (reverse causality). The main limitation of this kind of research is that assumptions need to be m...
Source: NHS News Feed - June 26, 2013 Category: Consumer Health News Tags: Obesity Lifestyle/exercise Source Type: news

The Prevalence and Predictors of Androgen Deficiency in Taiwanese Men With Type 2 Diabetes
Conclusion: One third of Taiwanese men with T2DM have AD. The major predictors of AD are linked to obesity, which is a potentially modifiable risk factor, and may represent an important avenue for intervention.
Source: Urology - May 13, 2013 Category: Urology & Nephrology Authors: Rue-Tsuan Liu, Min-Shen Chung, Pei-Wen Wang, Chung-Dar Chen, Jong-Jer Lee, Wei-Chia Lee, Michael B. Chancellor, Kuender D. Yang, Yao-Chi Chuang Tags: Male Sexual Dysfunction Source Type: research

Good Fat, Bad Fat The Increasingly Complex Interplay of Adipose Tissue and the Cardiovascular System ∗
Obesity is present in more than 30% of adults in the United States and is a known risk factor for a variety of cardiovascular problems, including coronary artery disease, atrial fibrillation, congestive heart failure, and stroke (1). Obesity is considered to be present when there is an excess mass of adipose tissue in the body. There is now widespread acceptance of the notion that regional fat stores might have specific local or systemic effects. The best-known example of a local fat depot with a specific effect is the case of excess fat within the abdominal cavity, which seems to contribute to insulin resistance, raised b...
Source: Journal of the American College of Cardiology: Cardiovascular Interventions - July 1, 2013 Category: Cardiology Source Type: research

Headache linked with incidence of metabolic syndrome: Comment on migraine, headache and development of metabolic syndrome: An 11-year follow-up in the HUNT study
A considerable body of evidence from large-population studies has linked migraine, particularly with aura, to somewhat increased risk for stroke, coronary heart disease, and subclinical infarct-like lesions as well as to adverse risk profiles for cardiovascular disease (CVD), including hyperlipidemia, obesity, hypertension, and family history of premature CVD . Although the biological mechanisms remain uncertain, this area of research has importance for public health, especially because both migraine and CVD are common in the general population. Understanding the mechanisms that link migraine with various manifestations of...
Source: Pain - May 17, 2013 Category: Anesthesiology Authors: Jameson D. Voss, Ann I. Scher Tags: Commentaries Source Type: research