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Condition: Huntington's Disease

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Total 289 results found since Jan 2013.

Targeting molecules to medicine with mTOR, autophagy, and neurodegenerative disorders
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Source: British Journal of Clinical Pharmacology - October 15, 2015 Category: Drugs & Pharmacology Authors: Kenneth Maiese Tags: Review ‐ Themed Issue Source Type: research

Rutgers Genetics Research Center awarded $6 million federal grant
(Rutgers University) The National Institute of Neurological Disorders and Stroke (NINDS) has awarded a five-year grant worth up to $6,034,323 to RUCDR Infinite Biologics, a unit of Rutgers' Human Genetics Institute of New Jersey. With the new grant, the Rutgers operation will take over management of the NINDS stem cell repository. RUCDR also will provide a comprehensive range of stem-cell related services to researchers throughout the world investigating diseases including Parkinson's, amyotrophic lateral sclerosis and Huntington's.
Source: EurekAlert! - Medicine and Health - October 20, 2015 Category: Global & Universal Source Type: news

The carbonic anhydrase inhibitor methazolamide prevents amyloid beta-induced mitochondrial dysfunction and caspase activation protecting neuronal and glial cells in vitro and in the mouse brain.
Abstract Mitochondrial dysfunction has been recognized as an early event in Alzheimer's disease (AD) pathology, preceding and inducing neurodegeneration and memory loss. The presence of cytochrome c (CytC) released from the mitochondria into the cytoplasm is often detected after acute or chronic neurodegenerative insults, including AD. The carbonic anhydrase inhibitor (CAI) methazolamide (MTZ) was identified among a library of drugs as an inhibitor of CytC release and proved to be neuroprotective in Huntington's disease and stroke models. Here, using neuronal and glial cell cultures, in addition to an acute model ...
Source: Neurobiology of Disease - November 12, 2015 Category: Neurology Authors: Fossati S, Giannoni P, Solesio ME, Cocklin SL, Cabrera E, Ghiso J, Rostagno A Tags: Neurobiol Dis Source Type: research

Levels and actions of neuroactive steroids in the nervous system under physiological and pathological conditions: sex-specific features
Publication date: Available online 2 December 2015 Source:Neuroscience & Biobehavioral Reviews Author(s): Roberto C. Melcangi, Silvia Giatti, Luis M. Garcia-Segura MELCANGI, R.C., S. Giatti and L.M. Garcia-Segura. Levels and actions of neuroactive steroids in the nervous system under physiological and pathological conditions: Sex-specific features. NEUROSCI BIOBEHAV REV XX(XX) XXX-XXX, 2015.- Neuroactive steroids regulate the physiology of the central and peripheral nervous system, exert neuroprotective actions and represent interesting tools for therapeutic strategies against neurodegenerative and psychiatric...
Source: Neuroscience and Biobehavioral Reviews - December 3, 2015 Category: Neuroscience Source Type: research

The Impact of Huntington Disease on Family Carers: a Literature Overview.
Authors: Domaradzki J Abstract Caring for a person with chronic disease often rests on the patient's family. Nevertheless, most studies on the needs, quality of life and caregiver burden focus on different types of dementia, including Alzheimer's and Parkinson's disease, stroke, cancer or mental illnesses. Less attention has been paid to informal caregivers of patients with Huntington's disease (HD). Meanwhile, psychosocial implications of HD are much more serious and wide-ranging. Thus, this paper aims to review the literature on the costs of caring for a person with HD (pHD). The review identifies the aspects of ...
Source: Psychiatria Polska - December 23, 2015 Category: Psychiatry Tags: Psychiatr Pol Source Type: research

Targeting molecules to medicine with mTOR, autophagy and neurodegenerative disorders
Neurodegenerative disorders are significantly increasing in incidence as the age of the global population continues to climb with improved life expectancy. At present, more than 30 million individuals throughout the world are impacted by acute and chronic neurodegenerative disorders with limited treatment strategies. The mechanistic target of rapamycin (mTOR), also known as the mammalian target of rapamycin, is a 289 kDa serine/threonine protein kinase that offers exciting possibilities for novel treatment strategies for a host of neurodegenerative diseases that include Alzheimer's disease, Parkinson's disease, Huntington'...
Source: British Journal of Clinical Pharmacology - December 26, 2015 Category: Drugs & Pharmacology Authors: Kenneth Maiese Tags: Review‐Themed Issue Source Type: research

Induction of neurorestoration from endogenous stem cells.
Abstract Neural stem cells persist in the subventricular zone lining the ventricle of the adult brain. The resident stem/progenitor cells can be stimulated in vivo by neurotrophic factors, hematopoietic growth factors, magnetic stimulation and/or physical exercise. In both animals and humans, the differentiation and survival of neurons arising from the subventricular zone may be also regulated by the trophic factors. The presence of stem/progenitor cells in the adult brain and the fact that the production of new neurons occurs at specific sites suggest a possibility for the treatment of otherwise incurable neurolo...
Source: Cell Transplantation - January 18, 2016 Category: Cytology Authors: Yu JH, Seo JH, Lee JY, Lee MY, Cho SR Tags: Cell Transplant Source Type: research

Cannabinoid pharmacology in cancer research: A new hope for cancer patients?
Abstract Cannabinoids have been used for many centuries to ease pain and in the past decade, the endocannabinoid system has been implicated in a number of pathophysiological conditions, such as mood and anxiety disorders, movement disorders such as Parkinson's and Huntington's disease, neuropathic pain, multiple sclerosis, spinal cord injury, atherosclerosis, myocardial infarction, stroke, hypertension, glaucoma, obesity, and osteoporosis. Several studies have demonstrated that cannabinoids also have anti-cancer activity and as cannabinoids are usually well tolerated and do not produce the typical toxic effects of...
Source: European Journal of Pharmacology - February 4, 2016 Category: Drugs & Pharmacology Authors: Javid FA, Phillips RM, Afshinjavid S, Verde R, Ligresti A Tags: Eur J Pharmacol Source Type: research

Scientists win $1.7 million grant to advance new strategies to treat Huntington's disease
(Scripps Research Institute) Scientists from the Florida campus of The Scripps Research Institute have won nearly $1.7 million from the National Institutes of Health's National Institute of Neurological Disorders and Stroke to investigate the mechanisms that contribute to Huntington's disease, a fatal inherited disease that some have described as having ALS, Parkinson's and Alzheimer's -- at the same time.
Source: EurekAlert! - Biology - February 12, 2016 Category: Biology Source Type: news

Neurotrophins' Modulation by Olive Polyphenols.
CONCLUSIONS: In this context, a better understanding of the effects of polyphenols on neurotrophins and their receptors (TrkA, TrkB, p75NTR) could certainly generate interest for drug discovery and also for the potential dietary prevention of several neurological and cardiometabolic diseases. PMID: 27356540 [PubMed - as supplied by publisher]
Source: Current Medicinal Chemistry - June 25, 2016 Category: Chemistry Authors: Fiore M, Ceccanti M, Carito V, Tarani L, Ferraguti G, Chaldakov GN Tags: Curr Med Chem Source Type: research

Endocannabionoid System in Neurological Disorders.
Authors: Bifulco M, Laezza C, Malfitano AM Abstract BACKGROUND: Several studies support the evidence that the endocannabinoid system and cannabimimetic drugs might have therapeutic potential in numerous pathologies. These pathologies range from neurological disorders, atherosclerosis, stroke, cancer to obesity/metabolic syndrome and others. METHODS: In this paper we review the endocannabinoid system signaling and its alteration in neurodegenerative disorders like multiple sclerosis, Alzheimer's disease, Parkinson's disease and Huntington's disease and discuss the main findings about the use of cannabinoids in t...
Source: Recent Patents on CNS Drug Discovery - July 2, 2016 Category: Drugs & Pharmacology Tags: Recent Pat CNS Drug Discov Source Type: research

Involvement of heme oxygenase-1 induction in the cytoprotective and neuroinflammatory activities of Siegesbeckia Pubescens isolated from 5,3'-dihydroxy-3,7,4'-trimethoxyflavone in HT22 cells and BV2 cells.
This study provides evidence that 5,3'-dihydroxy-3,7,4'-trimethoxyflavone (DTMF), a compound isolated from 90% MeOH extract of Siegesbeckia pubescens, effectively has neuroprotective and anti-neuroinflammatory activities. DTMF has cytoprotective and reactive oxygen species (ROS) reductive effects in HT22 cells. DTMF also decreased LPS-induced inducible nitric oxide synthase (iNOS), cyclooxygenase (COX-2) expression but attenuated LPS-induced nitrite (NO) and prostaglandin E2 (PGE2), as well as TNF-α and IL-1β production. In addition, DTMF induced Heme oxygenase (HO)-1 expression, HO activity, nuclear transcription factor...
Source: International Immunopharmacology - August 28, 2016 Category: Allergy & Immunology Authors: Lee DS, Lee M, Sung SH, Jeong GS Tags: Int Immunopharmacol Source Type: research

Creatine Revealed Anticonvulsant Properties on Chemically and Electrically Induced Seizures in ...
In conclusion, creatine exerts anticonvulsant effects in three seizure models; therefore it may act as a potential drug to help patients with convulsions. However, further investigations should be done to clarify these results more.
Source: Iranian Journal of Pharmaceutical Research - November 14, 2016 Category: Drugs & Pharmacology Source Type: research

Adaptive Responses of Neuronal Mitochondria to Bioenergetic Challenges: Roles in Neuroplasticity and Disease Resistance.
Abstract An important concept in neurobiology is "neurons that fire together, wire together" which means that the formation and maintenance of synapses is promoted by activation of those synapses. Very similar to the effects of the stress of exercise on muscle cells, emerging findings suggest that neurons respond to activity by activating signaling pathways (e.g., Ca(2+), CREB, PGC-1α, NF-κB) that stimulate mitochondrial biogenesis and cellular stress resistance. These pathways are also activated by aerobic exercise and food deprivation, two bioenergetic challenges of fundamental importance in the evolution of t...
Source: Free Radical Biology and Medicine - November 27, 2016 Category: Biology Authors: Raefsky SM, Mattson MP Tags: Free Radic Biol Med Source Type: research

Verily launches Liftware smart utensils
Verily Life Sciences, the healthcare play owned by Google parent Alphabet (NSDQ:GOOGL), said this week it launched the Liftware Level smart utensil designed to aid individuals with limited hand or arm mobility. The Liftware Level is designed to help individuals who have hand and arm mobility issues, including those with cerebral palsy, spinal cord injuries, Huntington’s disease or post-stroke deficits. The device operates by constantly monitoring the position of the hand, based on the handle, and intelligently adjusting the angle of the utensil, either a spoon or fork, so the user can eat without the contents s...
Source: Mass Device - December 8, 2016 Category: Medical Equipment Authors: Fink Densford Tags: Business/Financial News Verily Source Type: news