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Condition: Huntington's Disease

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Total 289 results found since Jan 2013.

Linking Genes to Neurological Clinical Practice: The Genomic Basis for Neurorehabilitation
Large-scale genomics projects such as the Human Genome Project and the International HapMap Project promise significant advances in the ability to diagnose and treat many conditions, including those with a neurological basis. A major focus of research has emerged in the neurological sciences to elucidate the molecular and genetic basis of various neurological diseases. Indeed, genetic factors are implicated in susceptibility for many neurological disorders, with family history studies providing strong evidence of familial risk for conditions such as stroke, Parkinson's, Alzheimer's, and Huntington's diseases. Heritability ...
Source: Journal of Neurologic Physical Therapy - December 23, 2014 Category: Physiotherapy Tags: Special Interest Articles Source Type: research

Linking Genes to Neurological Clinical Practice: The Genomic Basis for Neurorehabilitation
Large-scale genomics projects such as the Human Genome Project and the International HapMap Project promise significant advances in the ability to diagnose and treat many conditions, including those with a neurological basis. A major focus of research has emerged in the neurological sciences to elucidate the molecular and genetic basis of various neurological diseases. Indeed, genetic factors are implicated in susceptibility for many neurological disorders, with family history studies providing strong evidence of familial risk for conditions such as stroke, Parkinson's, Alzheimer's, and Huntington's diseases. Heritability ...
Source: Journal of Neurologic Physical Therapy - January 1, 2015 Category: Physiotherapy Tags: Special Interest Articles Source Type: research

Adipose Tissue Derived Stem Cells in Neural Regenerative Medicine.
In this study, several human clinical trials using ADSCs for neuronal disorders were investigated. It is suggested that ADSCs are one of the choices among various stem cells for translating into clinical application in the near future. PMID: 25647067 [PubMed - as supplied by publisher]
Source: Cell Transplantation - February 2, 2015 Category: Cytology Authors: Yeh DC, Chan TM, Harn HJ, Chiou TW, Chen HS, Lin ZS, Lin SZ Tags: Cell Transplant Source Type: research

Zinc: indications in brain disorders
This article is protected by copyright. All rights reserved.
Source: Fundamental and Clinical Pharmacology - February 1, 2015 Category: Drugs & Pharmacology Authors: Atish Prakash, Kanchan Bharti, Abu Bakar Abdul Majeed Tags: Review Article Source Type: research

Individuals with neurological diseases are at increased risk of fractures within 180 days of admission to long-term care in Ontario
Conclusion: LTC residents with ADRD, epilepsy and traumatic brain injury are at a higher risk for sustaining an incident fracture in the first 180 days of admission and should be considered for fracture prevention strategies.
Source: Age and Ageing - February 23, 2015 Category: Geriatrics Authors: Jantzi, M., Maher, A. C., Ioannidis, G., Hirdes, J. P., Giangregorio, L. M., Papaioannou, A. Tags: Research Papers Source Type: research

Precision medicine is coming, but not anytime soon
President Obama’s announcement of a Precision Medicine Initiative was one of the few items in this year’s State of the Union address to garner bipartisan support. And for good reason. Precision medicine, also known as personalized medicine, offers the promise of health care — from prevention to diagnosis to treatment — based on your unique DNA profile. Who wouldn’t want that? We’ve already had a taste of precision medicine. Relatively low-tech therapies like eyeglasses, orthotic devices, allergy treatments, and blood transfusions have long been personalized for the individual. Genetic analysis o...
Source: New Harvard Health Information - March 26, 2015 Category: Consumer Health News Authors: Beverly Merz Tags: Health care personalized health care precision medicine Source Type: news

Design and development of a novel supportive care product for the treatment of sialorrhea in Parkinson's disease.
Abstract Sialorrhea or excessive drooling is a significant medical issue in Parkinson's disease (PD) and neurodegenerative disorders, although it is often underreported by patients. Sialorrhea affects a large proportion of PD patients, ranging up to 78% in advanced stages, with many PD patients considering drooling as their worst non-motor symptom. Sialorrhea affects up to a million patients with diverse neurological impairments, including cerebral palsy, amyotrophic lateral sclerosis (ALS), Huntington's, survivors of stroke and severe traumatic brain injury. Numerous approaches have been attempted to treat sialor...
Source: Current Topics in Medicinal Chemistry - April 4, 2015 Category: Chemistry Authors: Farber NM, Perez-Lloret S, Gamzu ER Tags: Curr Top Med Chem Source Type: research

Scripps Florida scientists win $2.1 million to study protein linked to Parkinson's disease
(Scripps Research Institute) Scientists from the Florida campus of The Scripps Research Institute have been awarded $2.1 million from the National Institute of Neurological Disorders and Stroke to study a protein that has been closely linked in animal models to Parkinson's disease and Huntington's disease.
Source: EurekAlert! - Medicine and Health - June 10, 2015 Category: Global & Universal Source Type: news

An introduction to the roles of purinergic signalling in neurodegeneration, neuroprotection and neuroregeneration.
Abstract Purinergic signalling appears to play important roles in neurodegeneration, neuroprotection and neuroregeneration. Initially there is a brief summary of the background of purinergic signalling, including release of purines and pyrimidines from neural and non-neural cells and their ectoenzymatic degradation, and the current characterisation of P1 (adenosine), and P2X (ion channel) and P2Y (G protein-coupled) nucleotide receptor subtypes. There is also coverage of the localization and roles of purinoceptors in the healthy central nervous system. The focus is then on the roles of purinergic signalling in tra...
Source: Neuropharmacology - June 5, 2015 Category: Drugs & Pharmacology Authors: Burnstock G Tags: Neuropharmacology Source Type: research

Comparative assessment of different methods for the estimation of gait temporal parameters using a single inertial sensor: application to elderly, post-stroke, Parkinson's disease and Huntington's disease subjects
The assessment of the temporal and spatial parameters of gait is commonly considered of importance in clinical gait analysis since it contributes to the quantitative characterization of many common gait abnormalities. The determination of these parameters requires the detection of the initial and final foot contacts (IC and FC), usually referred to as gait events (GEs). Inertial measurement units (IMUs) have been increasingly employed for this purpose thanks to their high wearability, reduced cost and low power consumption.
Source: Gait and Posture - June 24, 2015 Category: Orthopaedics Authors: Diana Trojaniello, Andrea Ravaschio, Jeffrey M. Hausdorff, Andrea Cereatti Tags: Full length Article Source Type: research

Regenerative cellular Therapies for neurologic Diseases.
Abstract The promise of stem cell regeneration has been the hope of many neurologic patients with permanent damage to the central nervous system. There are hundreds of stem cell trials worldwide intending to test the regenerative capacity of stem cells in various neurological conditions from Parkinson's disease to multiple sclerosis. Although no stem cell therapy is clinically approved for use in any human disease indication, patients are seeking out trials and asking clinicians for guidance. This review summarizes the current state of regenerative stem cell transplantation divided into seven conditions for which ...
Source: Brain Research - July 31, 2015 Category: Neurology Authors: Levy M, Boulis N, Rao M, Svendsen CN Tags: Brain Res Source Type: research

Scientists adopt new strategy to find Huntington's disease therapies
(NIH/National Institute of Neurological Disorders and Stroke) Scientists searched the chromosomes of more than 4,000 Huntington's disease patients and found that DNA repair genes may determine when the neurological symptoms begin. The results may provide a guide for discovering new treatments for Huntington's disease and a roadmap for studying other neurological disorders.
Source: EurekAlert! - Medicine and Health - August 7, 2015 Category: Global & Universal Source Type: news

Development of obsessive compulsive disorder (ocd) secondary to traumatic brain injury-review of literature and comparison with sample of patients from lishman unit, maudsley hospital
Conclusion The main focus of organic OCD seems to be from disruption to the OFC and basal ganglia but other areas have been implicated as has been reflected in the literature as well as the patients on the Lishman brain injury unit, Maudsley Hospital.
Source: Journal of Neurology, Neurosurgery and Psychiatry - August 13, 2015 Category: Neurosurgery Authors: Guillochon, R., Dilley, M. Tags: Genetics, Drugs: CNS (not psychiatric), Epilepsy and seizures, Movement disorders (other than Parkinsons), Neurological injury, Parkinson's disease, Stroke, Trauma CNS / PNS, Anxiety disorders (including OCD and PTSD), Radiology, Radiology (diagnostics), Source Type: research

Experimental Brain Ischemic Preconditioning: A Concept to Putative Targets.
Abstract Neurodegeneration is the progressive loss of central neurons which may instigate many disabling psychological and neurological disorders like Alzheimer's disease, Schizophrenia, Parkinson's disease, prion's disease, and Huntington disease. It has become imperative to address the need to discover novel molecular targets and therapeutic strategies to combat neurodegeneration. It is more essential to do so because most of the accessible treatment focuses on correcting the symptoms of such diseases rather than the actual pathophysiology. In this article we sought to discuss plausible connections between Brain...
Source: CNS and Neurological Disorders Drug Targets - August 21, 2015 Category: Drugs & Pharmacology Authors: Sharma A, Goyal R Tags: CNS Neurol Disord Drug Targets Source Type: research

Informal caregivers of clients with neurological conditions: profiles, patterns and risk factors for distress from a home care prevalence study
Conclusions: Neurological conditions are common among home care clients and a significant proportion of informal caregivers providing care to these clients experience distress. The complexity of clients with neurological conditions suggests the need for multicomponent support strategies for informal caregivers.
Source: BMC Health Services Research - August 28, 2015 Category: Journals (General) Authors: Lori MitchellJohn HirdesJeff PossCaroline Slegers-BoydHilary CaldarelliLynn Martin Source Type: research