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AKI and Long-Term Risk for Cardiovascular Events and Mortality
In conclusion, AKI associates with an elevated risk of cardiovascular mortality and major cardiovascular events, particularly heart failure and acute myocardial infarction.
Source: Journal of the American Society of Nephrology : JASN - December 29, 2016 Category: Urology & Nephrology Authors: Odutayo, A., Wong, C. X., Farkouh, M., Altman, D. G., Hopewell, S., Emdin, C. A., Hunn, B. H. Tags: Meta-Analysis Source Type: research

Epidemiology and Natural History of the Cardiorenal Syndromes in a Cohort with Echocardiography.
CONCLUSIONS: Up to 19% of patients with a chronic form of cardiorenal syndrome will subsequently develop an acute syndrome. Development of acute or type 4 cardiorenal syndrome is independently associated with mortality, the acute form having the worst prognosis. PMID: 28801528 [PubMed - as supplied by publisher]
Source: Clinical Journal of the American Society of Nephrology : CJASN - August 11, 2017 Category: Urology & Nephrology Authors: Mavrakanas TA, Khattak A, Singh K, Charytan DM Tags: Clin J Am Soc Nephrol Source Type: research

Randomized Trial Comparing Proactive, High-Dose versus Reactive, Low-Dose Intravenous Iron Supplementation in Hemodialysis (PIVOTAL): Study Design and Baseline Data.
CONCLUSIONS: PIVOTAL will provide important information about the optimum dosing of IV iron in HD patients representative of usual clinical practice. TRIAL REGISTRATION: EudraCT number: 2013-002267-25. PMID: 30304714 [PubMed - as supplied by publisher]
Source: American Journal of Nephrology - October 10, 2018 Category: Urology & Nephrology Authors: Macdougall IC, White C, Anker SD, Bhandari S, Farrington K, Kalra PA, McMurray JJV, Murray H, Steenkamp R, Tomson CRV, Wheeler DC, Winearls CG, Ford I, on behalf of the PIVOTAL Trial investigators Tags: Am J Nephrol Source Type: research

Intensive versus Usual Control of Hypertension in the Prevention of Cardiovascular and Renal Outcomes: A Cumulative Meta-Analysis of Randomized Controlled Trials
Conclusion: The findings of this study suggest that IBP control plays a beneficial role in the prevention of some major cardiovascular events, including myocardial infarction, stroke, and albuminuria.Kidney Blood Press Res
Source: Kidney and Blood Pressure Research - May 10, 2019 Category: Urology & Nephrology Source Type: research

Association of autosomal dominant polycystic kidney disease with cardiovascular disease: a US-National Inpatient Perspective
ConclusionsThe prevalence of CVD is high among patients with ADPKD, and the most important risk factor associated with CVD is severity of RD. We found an increase in the trend of hospitalizations of patients with ADPKD associated with increased risk of AF, PHN, NICM, and hemorrhagic stroke. History of CVD is the strongest predictor of mortality among patients with ADPKD.
Source: Clinical and Experimental Nephrology - February 25, 2022 Category: Urology & Nephrology Source Type: research

Prediction of cardiovascular outcome by estimated glomerular filtration rate among high-risk patients: a Thai nationwide cohort study
ConclusionLower baseline kidney function was independently associated with increased risk of CV events and all-cause mortality in Thai populations at high CV risk.
Source: Clinical and Experimental Nephrology - August 23, 2022 Category: Urology & Nephrology Source Type: research

Fibroblast Growth Factor-23 and Risk of Cardiovascular Diseases: A Mendelian Randomization Study
CONCLUSIONS: Genetically predicted FGF-23 levels are not associated with atherosclerotic and nonatherosclerotic cardiovascular diseases, suggesting no important causal link.PODCAST: This article contains a podcast at https://dts.podtrac.com/redirect.mp3/www.asn-online.org/media/podcast/CJASN/2023_01_10_CJN05080422.mp3.PMID:36719157 | DOI:10.2215/CJN.05080422
Source: Clinical Journal of the American Society of Nephrology : CJASN - January 31, 2023 Category: Urology & Nephrology Authors: Killian Donovan William G Herrington Guillaume Par é Marie Pigeyre Richard Haynes Rebecca Sardell Adam S Butterworth Lasse Folkersen Stefan Gustafsson Qin Wang Colin Baigent Anders M älarstig Michael V Holmes Natalie Staplin SCALLOP Consortium Source Type: research

Predictors of quality of life in patients within the first year of commencing haemodialysis based on baseline data from the PIVOTAL trial and associations with the study outcomes
CONCLUSION: Quality of life was impaired in patients starting haemodialysis. A higher C-reactive protein level level was a consistent independent predictor of the majority of worse quality of life. Transferrin saturation ≤ 20% was associated with worse physical component score of quality of life. Baseline quality of life was predictive of all-cause mortality and the primary outcome measure.EUDRACT REGISTRATION NUMBER: 2013-002267-25.PMID:36995528 | PMC:PMC10061401 | DOI:10.1007/s40620-023-01571-6
Source: Journal of Nephrology - March 30, 2023 Category: Urology & Nephrology Authors: Sunil Bhandari Patrick Parfrey Claire White Stefan D Anker Kenneth Farrington Ian Ford Philip A Kalra John J V McMurray Michele Robertson Charles R V Tomson David C Wheeler Iain C Macdougall PIVOTAL Investigators, Committees Source Type: research

The number of valvular insufficiency is a strong predictor of cardiovascular and all-cause mortality in hemodialysis patients
ConclusionsIn maintenance HD patients, the prevalence of VI is prominently high. The number of VI  ≥ 2 is associated with emergency hospitalized for acute heart failure, cardiovascular and all-cause mortality. Combining age, number of VI ≥ 2, and albumin can predict cardiovascular and all-cause mortality.
Source: International Urology and Nephrology - April 3, 2023 Category: Urology & Nephrology Source Type: research

Cardiovascular risk in women attending primary care centres: baseline data of the EVA study
Conclusions Four in 10 women attending primary care centres had a high or very high cardiovascular risk. Percentages of classic cardiovascular risk factors were higher in HT than in NHT and increased significantly with age. The most commonly used drugs were renin–angiotensin system blockers and diuretics.
Source: Nephrology Dialysis Transplantation - December 20, 2012 Category: Urology & Nephrology Authors: Fernandez-Vega, F., Prieto-Diaz, M. A., Redondo, M., Garcia-Norro, F. J., Suliman, N., Diaz, A., Vidal, C., Rodriguez, J. M., Montero, F. J., Gonzalez, M. B., Suarez, S., Garcia, J. J., Redondo, P. Tags: Original articles Source Type: research

Effect of Early Initiation of Dialysis on Cardiac Structure and Function: Results From the Echo Substudy of the IDEAL Trial
Conclusions: Advanced cardiac disease in these patients with stage 5 chronic kidney disease did not progress during the 12-month study period and planned early initiation of dialysis therapy did not result in differences in any echocardiographic variables of cardiac structure and function.
Source: American Journal of Kidney Diseases - November 16, 2012 Category: Urology & Nephrology Authors: Gillian A. Whalley, Tom H. Marwick, Robert N. Doughty, Bruce A. Cooper, David W. Johnson, Andrew Pilmore, David C.H. Harris, Carol A. Pollock, John F. Collins, IDEAL Echo Substudy Investigators Tags: Dialysis Source Type: research

Evaluation of cardiovascular disease burden and therapeutic goal attainment in US adults with chronic kidney disease: an analysis of national health and nutritional examination survey data, 2001--2010
Conclusions: Individuals with CKD have a high prevalence of CV-related comorbidities. However, attainment of LDL-C or BP goals was low regardless of disease stage. These findings highlight the potential for intensive risk factor modification to maximize CV event reduction in CKD patients at high risk for CHD.
Source: BMC Nephrology - June 27, 2013 Category: Urology & Nephrology Authors: Andreas KuznikJack MardekianLisa Tarasenko Source Type: research

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