Filtered By:
Condition: Down's Syndrome

This page shows you your search results in order of relevance.

Order by Relevance | Date

Total 53 results found since Jan 2013.

A comprehensive exercise program for a young adult male with Down syndrome who experienced a stroke.
Conclusion: Improved cardiorespiratory fitness, strength, balance and mobility provide preliminary evidence of the trainability of individuals with both DS and stroke. Future studies are warranted to investigate the role of exercise in risk factor reduction for primary and secondary prevention of stroke in people with DS. Implications for Rehabilitation Individuals with Down syndrome (DS) may be at heightened risk of stroke due to a combination of physiological conditions and lifestyle choices which contribute to reduced exercise capacity, accelerated aging patterns, moyamoya syndrome and physical inactivity as well as hig...
Source: Disability and Rehabilitation - September 10, 2013 Category: Rehabilitation Authors: Casey AF, Mackay-Lyons M, Connolly EM, Jennings C, Rasmussen R Tags: Disabil Rehabil Source Type: research

Down syndrome and arterial ischemic stroke in childhood: A potential immunologic link with selective IgG4 subclass deficiency.
We report four children with Down Syndrome (DS) without evidence of congenital heart disease who sustained cerebral infarction in the context of an infectious disease. In one child, stroke occurred in the context of acute infection with Mycoplasma pneumonia. In another child, stroke occurred in the context of Streptococcus oralis (viridans subgroup) infection. In two other children, stroke occurred in the context of a bibasilar pneumonia for which an etiologic agent was not found. All patients had evidence of selective IgG4 subclass deficiency. We followed 8 other children with down syndrome with infectious diseases, but w...
Source: European Journal of Paediatric Neurology - February 25, 2014 Category: Neurology Authors: Pavone P, Falsaperla R, De Silva K, Taibi R, Verrotti A, Trifiletti RR, Vitaliti G Tags: Eur J Paediatr Neurol Source Type: research

Neuroprotective effects of Sonic hedgehog agonist SAG in a rat model of neonatal stroke
CONCLUSIONS: These findings indicate benefit of one-time SAG treatment post insult in reducing brain injury and improving behavioral outcome after experimental neonatal stroke.IMPACT: A one-time dose of small molecule Sonic hedgehog agonist protected against neonatal stroke and improved long-term behavioral outcomes in a rat model. This study extends the use of Sonic hedgehog in treating developing brain injury, previously shown in animal models of Down syndrome and cerebellar injury. Sonic hedgehog agonist is one of the most promising therapies in treating neonatal stroke thanks to its safety profile and low dosage.PMID:3...
Source: Pediatric Research - March 3, 2021 Category: Pediatrics Authors: Vien Nguyen Manideep Chavali Amara Larpthaveesarp Srikirti Kodali Ginez Gonzalez Robin J M Franklin David H Rowitch Fernando Gonzalez Source Type: research

The Burden of Dementia due to Down Syndrome, Parkinson ’s Disease, Stroke, and Traumatic Brain Injury: A Systematic Analysis for the Global Burden of Disease Study 2019
Background: In light of the increasing trend in the global number of individuals affected by dementia and the lack of any available disease-modifying therapies, it is necessary to fully understand and quantify the global burden of dementia. This work aimed to estimate the proportion of dementia due to Down syndrome, Parkinson ’s disease, clinical stroke, and traumatic brain injury (TBI), globally and by world region, in order to better understand the contribution of clinical diseases to dementia prevalence.Methods: Through literature review, we obtained data on the relative risk of dementia with each condition and estima...
Source: Neuroepidemiology - June 28, 2021 Category: Epidemiology Source Type: research

Stroke After Adenotonsillectomy in Patients With Undiagnosed Moyamoya Syndrome
Conclusions and RelevanceClinicians should be aware of an elevated prevalence of moyamoya syndrome in Down syndrome and sickle cell disease populations and should consider moyamoya syndrome in the differential diagnosis of postoperative stroke. Stroke risk is magnified in the perioperative setting related to perioperative dehydration and hypotension. Awareness and screening for cerebral vasculopathy in high-risk populations could prompt measures to decrease the occurrence of postoperative strokes after adenotonsillectomies.
Source: JAMA Otolaryngology - Head and Neck Surgery - November 1, 2014 Category: ENT & OMF Source Type: research

Hemorrhagic stroke, cerebral amyloid angiopathy, Down syndrome and the Boston criteria.
Abstract A stroke, or a cerebrovascular accident (CVA) is a life-threatening condition which often results in permanent or significant disability in the adult population. Several classifications of CVAs exist, one of them being based on the mechanism of injury of brain tissue: ischemic (85-90%) and hemorrhagic (10-15%). In a hemorrhagic stroke an intercranial bleeding occurs, leading to the formation of a focal hematoma typically located in the basal ganglia of the brain (approx. 45% of cases). A common yet underestimated cause of intracerebral hemorrhage is cerebral small vessel disease with microhemorrhages, inc...
Source: Neurologia i Neurochirurgia Polska - May 1, 2015 Category: Neurology Authors: Jastrzębski K, Kacperska MJ, Majos A, Grodzka M, Głąbiński A Tags: Neurol Neurochir Pol Source Type: research

Idiopathic pulmonary hemosiderosis and stroke secondary to protein C deficiency in a child with Down syndrome: a case report
ConclusionIdiopathic pulmonary hemosiderosis remains a severe disease, which is rarely associated with Down syndrome. The management of this disease in Down syndrome patients is difficult, especially when associated with an ischemic stroke secondary to protein C deficiency.
Source: Journal of Medical Case Reports - March 11, 2023 Category: General Medicine Source Type: research

High blood pressure: Why me?
“I go to the gym, and I never add salt. So why do I have high blood pressure?” Despite its astonishing prevalence of one in three Americans, many people struggle with the diagnosis of high blood pressure, or hypertension. It’s worth exploring why, because being an active participant in your care is crucial for optimal blood pressure control. Certain features make any diagnosis easier to accept: First, people are more likely to accept a diagnosis if they have symptoms. A person with cough and fever will believe a diagnosis of pneumonia. But someone who feels fine would not. Next, people more readily accept a diagnosi...
Source: New Harvard Health Information - May 2, 2016 Category: Consumer Health News Authors: Naomi D. L. Fisher, MD Tags: Behavioral Health Health care Heart Health Hypertension and Stroke Prevention Screening high blood pressure Source Type: news

Moyamoya Disease Associated with Asymptomatic Mosaic Turner Syndrome: A Rare Cause of Hemorrhagic Stroke
We present the first reported case of an adult patient with previously unrecognized mosaic Turner syndrome with acute subarachnoid and intracerebral hemorrhage as the initial manifestation of moyamoya syndrome. A 52-year-old woman was admitted with a subarachnoid hemorrhage with associated flame-shaped intracerebral hemorrhage in the left frontal lobe. Physical examination revealed short stature, pectus excavatum, small fingers, micrognathia, and mild facial dysmorphism. Cerebral angiography showed features consistent with bilateral moyamoya disease, aberrant intrathoracic vessels, and an unruptured 4-mm right superior hyp...
Source: Journal of Stroke and Cerebrovascular Diseases - October 7, 2013 Category: Neurology Authors: Sunil Manjila, Benjamin R. Miller, Anitha Rao-Frisch, Balint Otvos, Anna Mitchell, Nicholas C. Bambakidis, Michael A. De Georgia Tags: Case Reports Source Type: research

Stroke in adults with Down syndrome
Down syndrome (DS) is the commonest chromosomal abnormality in live born infants [1]. Over the past decades, DS patients had a remarkable increase in their life expectancy [2], urging the need to improve our knowledge in age-related disorders, such as cerebrovascular diseases. DS patients are at increased risk of stroke when compared with age-matched individuals [3], however there are only few studies approaching this topic and none focusing on the adult population.
Source: Journal of the Neurological Sciences - February 6, 2017 Category: Neurology Authors: Jo ão Pedro Marto, Mariana Dias, José Nuno Alves, Vera Montes, José Beato-Coelho, Cláudia Marques-Matos, Ary de Sousa, Francisco Bernardo, Sofia Calado, Miguel Viana-Baptista Tags: Letter to the Editor Source Type: research

4 questions parents have about moyamoya disease
Last month, families from across the country gathered at Boston Children’s Hospital to celebrate World Moyamoya Day. The expert speakers at the Moyamoya Family Day Symposium shared the latest information about this rare but very serious condition with parents and patients alike. Moyamoya disease occurs when the walls of the internal carotid arteries — the vessels that supply blood to important areas of the brain — become thickened and narrowed. As a result, blood flow to the brain slows, making blood clots more likely. Kids with moyamoya disease are at significantly higher risk of having a stroke, as well as other co...
Source: Thrive, Children's Hospital Boston - June 13, 2017 Category: Pediatrics Authors: Jessica Cerretani Tags: Ask the Expert Diseases & Conditions Dr. Edward Smith moyamoya Moyamoya Disease Program Source Type: news

The reliability and validity of the Timed Up and Go as a clinical tool in individuals with and without disabilities across a lifespan: a systematic review.
Conclusions: Based on the literature assessed, the Timed Up and Go is clinically applicable and reliable across multiple populations. The Timed Up and Go has a wide variety of clinical use making it a diverse measure that should be considered when choosing an outcome an activity based outcome measure. However, there are some limitations in the validity of the utilization of the Timed Up and Go to some populations due to a lack of data and/or poor choice of comparison outcome measures when assessing validity. Additional research is needed for young to middle aged adults. IMPLICATIONS FOR REHABILITATION Outcome measures are ...
Source: Disability and Rehabilitation - October 25, 2019 Category: Rehabilitation Authors: Christopher A, Kraft E, Olenick H, Kiesling R, Doty A Tags: Disabil Rehabil Source Type: research

What Types of Memory Impairments are There in Children?
Discussion Memory is an important part of what distinguishes higher order species from others. Memory also is part of one’s self-identity. Difficulties in short-term memory can make common, everyday tasks difficult for the person experiencing the problem particularly if it recently occurred and the person’s long-term memory is intact. Difficulties with long-term memory can also have problems when language, events or even one’s own identity are affected. For some people the memory loss is temporary but for others, memory impairments are permanent and must be accepted and accommodated as part of the overall...
Source: PediatricEducation.org - March 30, 2020 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Go For The Glory Quiz: Down Syndrome Complications, Infant Shock, Stroke Survivors, Doxycycline Adverse Events
Go For The Glory Quiz: Test your skills in this week's 5-question quiz.
Source: Consultant Live - February 28, 2013 Category: Primary Care Source Type: news