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Condition: Spinal Cord Injury

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Total 1255 results found since Jan 2013.

The effects of robot-assisted gait training combined with non-invasive brain stimulation on lower limb function in patients with stroke and spinal cord injury: A systematic review and meta-analysis
ConclusionThis meta-analysis demonstrated that RAGT therapy in combination with NIBS was effective in patients with stroke and SCI. However, a greater improvement in lower limb function and activities were not observed using RAGT with tDCS compared to sham stimulation.
Source: Frontiers in Human Neuroscience - August 16, 2022 Category: Neuroscience Source Type: research

The central-peripheral coupling effect of ocular acupuncture kinesitherapy in post-stroke dyskinesia: A functional neuroimaging and neurotic electrophysiology study protocol
This study is registered with an identifier (ChiCTR2200060483) at the Chinese Clinical Trial Registry in June 2022. http://www.chictr.org.cn/index.aspx.
Source: Frontiers in Neurology - September 1, 2022 Category: Neurology Source Type: research

FDA approves OHSU device for stroke and spinal patients
Oregon Health and Science University on Thursday said the Food and Drug Administration has approved a device invented by one of its researchers to treat stroke and spinal cord-injury patients. The FDA clearance means OHSU researcher Dr. Paul Cordo and AMES Technology Inc. can sell the device as early as next year. The device is designed to rehabilitate damaged muscles. It uses robotic technology to help patients move areas affected by stroke and spinal cord injuries. "Taking stroke as an example,…
Source: bizjournals.com Health Care:Biotechnology headlines - May 30, 2013 Category: Biotechnology Authors: Matthew Kish Source Type: research

Impaired Limb Reaction to Displacement of Center of Gravity in Rats with Unilateral Striatal Ischemic Injury
Abstract Clinical stroke often results in impaired balance and increased vulnerability to severe injuries due to falling. To evaluate potential preclinical treatments that might target these deficits, it will be important to include tests capable of assessing these impairments chronically in animal models. Previously, we developed a postural instability test (PIT) that revealed chronic, unilateral impairments in postural stability in rat models of hemi-Parkinson’s disease (PD) and of unilateral cervical spinal cord injury. Here, we investigated whether this test was also capable of revealing long-term stroke-in...
Source: Translational Stroke Research - October 1, 2014 Category: Neurology Source Type: research

Gait recovery in a girl with ischemic spinal cord stroke.
DISCUSSION: The outcome was not anticipated for this client, given the type and level of her injury and the delay in starting gait training. PMID: 25822361 [PubMed - in process]
Source: Physical Therapy - April 1, 2015 Category: Physiotherapy Authors: McCain KJ, Farrar M, Smith PS Tags: Pediatr Phys Ther Source Type: research

Endogenous neural stem cell responses to stroke and spinal cord injury
Stroke and spinal cord injury (SCI) are among the most frequent causes of central nervous system (CNS) dysfunction, affecting millions of people worldwide each year. The personal and financial costs for affected individuals, their families, and the broader communities are enormous. Although the mammalian CNS exhibits little spontaneous regeneration and self‐repair, recent discoveries have revealed that subpopulations of glial cells in the adult forebrain subventricular zone and the spinal cord ependymal zone possess neural stem cell properties. These endogenous neural stem cells react to stroke and SCI by contributing a ...
Source: Glia - April 29, 2015 Category: Neurology Authors: Catherine‐Alexandra Grégoire, Brianna L. Goldenstein, Elisa M. Floriddia, Fanie Barnabé‐Heider, Karl J. L. Fernandes Tags: Review Source Type: research

Automated FES for Upper Limb Rehabilitation Following Stroke and Spinal Cord Injury
Neurorehabilitation aims to induce beneficial neural plasticity in order to restore function following injury to the nervous system. There is an increasing evidence that appropriately timed functional electrical stimulation (FES) can promote associative plasticity, but the dosage is critical for lasting functional benefits. Here, we present a novel approach to closed-loop control of muscle stimulation for the rehabilitation of reach-to-grasp movements following stroke and spinal cord injury (SCI). We developed a simple, low-cost device to deliver assistive stimulation contingent on users’ self-initiated movements. T...
Source: IEE Transactions on Neural Systems and Rehabilitation Engineering - May 1, 2018 Category: Neuroscience Source Type: research

Clinical Practice Guideline to Improve Locomotor Function Following Chronic Stroke, Incomplete Spinal Cord Injury, and Brain Injury.
DISCUSSION: The collective findings suggest that large amounts of task-specific (ie, locomotor) practice may be critical for improvements in walking function, although only at higher cardiovascular intensities or with augmented feedback to increase patient's engagement. Lower-intensity walking interventions or impairment-based training strategies demonstrated equivocal or limited efficacy. LIMITATIONS: As walking speed and distance were primary outcomes, the research participants included in the studies walked without substantial physical assistance. This guideline may not apply to patients with limited ambulatory fun...
Source: Physical Therapy - December 14, 2019 Category: Physiotherapy Authors: Hornby TG, Reisman DS, Ward IG, Scheets PL, Miller A, Haddad D, Fox EJ, Fritz NE, Hawkins K, Henderson CE, Hendron KL, Holleran CL, Lynskey JE, Walter A, and the Locomotor CPG Appraisal Team Tags: J Neurol Phys Ther Source Type: research

Knock down of lncRNA H19 promotes axon sprouting and functional recovery after cerebral ischemic stroke.
Abstract Ischemic stroke is a leading cause of irreversible brain damages and disabilities. In the past decade, much attention has been focused on exploring effective strategies to promote circuit reorganization and functional recovery post injury. Here, we showed that the expression level of a long non-coding RNA (lncRNA H19) is bilaterally increased in the sensorimotor cortex after a cerebral ischemia induced by middle cerebral artery occlusion (MCAO). Knock down of contralaterally elevated H19 robustly enhanced the midline-crossing sprouting of the intact corticospinal axons in the spinal cord. Furthermore, H19...
Source: Brain Research - January 24, 2020 Category: Neurology Authors: Hu S, Zheng J, Du Z, Wu G Tags: Brain Res Source Type: research

Sensors, Vol. 20, Pages 2748: Feasibility of a Sensor-Based Technological Platform in Assessing Gait and Sleep of In-Hospital Stroke and Incomplete Spinal Cord Injury (iSCI) Patients
jsers Recovery of the walking function is one of the most common rehabilitation goals of neurological patients. Sufficient and adequate sleep is a prerequisite for recovery or training. To objectively monitor patients’ progress, a combination of different sensors measuring continuously over time is needed. A sensor-based technological platform offers possibilities to monitor gait and sleep. Implementation in clinical practice is of utmost relevance and has scarcely been studied. Therefore, this study examined the feasibility of a sensor-based technological platform within the clinical setting. Participant...
Source: Sensors - May 11, 2020 Category: Biotechnology Authors: Maartje M. S. Hendriks Marije Vos-van der Hulst Noel L. W. Keijsers Tags: Article Source Type: research

Development and Preliminary Validation of a Pneumatic Focal Vibration System to the Mitigation of Post-Stroke Spasticity
This study will not only provide a potential tool to relieve post-stroke spasticity, but also contribute to improving the sensory and motor function of patients with other neurological diseases, e.g. spinal cord injury, multiple sclerosis, Parkinson and dystonia, etc.
Source: IEE Transactions on Neural Systems and Rehabilitation Engineering - March 5, 2021 Category: Neuroscience Source Type: research

Rehabilitative training paired with peripheral stimulation promotes motor recovery after ischemic cerebral stroke
In this study, we hypothesized that a combination of proprioceptive stimulation and rehabilitative training will promote neuroplasticity and functional recovery post injury. To test this hypothesis, we first established a photothrombotic stroke model that lesions the hindlimb sensorimotor cortex. Next, we demonstrated that injecting Cre-dependent AAV-retro viruses into the dorsal column of PV-Cre mice achieves specific and efficient targeting of proprioceptors. With chemogenetics, this method enables chronic activation of proprioceptors. We then assessed effects of combinatorial treatment on motor and sensory functional re...
Source: Experimental Neurology - December 26, 2021 Category: Neurology Authors: Shukun Hu Gang Wu Biwu Wu Zhouying Du Yi Zhang Source Type: research

Advances in the clinical application of orthotic devices for stroke and spinal cord injury since 2013
In this study, we reviewed the epidemiological characteristics of stroke and spinal cord injury, provided the therapeutic effect and recent advances in the application of conventional and new types of orthotic devices used in stroke and spinal cord injury in different joints of the upper and lower limbs, identified the shortcomings with these orthotics, and suggested directions for future research.
Source: Frontiers in Neurology - February 17, 2023 Category: Neurology Source Type: research

The Role of Progranulin (PGRN) in the Pathogenesis of Ischemic Stroke
Cell Mol Neurobiol. 2023 Aug 10. doi: 10.1007/s10571-023-01396-8. Online ahead of print.ABSTRACTStroke is a life-threatening medical condition and is a leading cause of disability. Cerebral ischemia is characterized by a distinct inflammatory response starting with the production of various cytokines and other inflammation-related agents. Progranulin (PGRN), a multifunctional protein, is critical in diverse physiological reactions, such as cell proliferation, inflammation, wound healing, and nervous system development. A mature PGRN is anti-inflammatory, while granulin, its derivative, conversely induces pro-inflammatory c...
Source: Cellular and Molecular Neurobiology - August 10, 2023 Category: Cytology Authors: Daryush Purrahman Ali Shojaeian Łukasz A Poniatowski Bart łomiej Piechowski-Jóźwiak Mohammad-Reza Mahmoudian-Sani Source Type: research