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Nutrition: Diets

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Total 16 results found since Jan 2013.

Melatonin modulates the aggravation of pyroptosis, necroptosis, and neuroinflammation following cerebral ischemia and reperfusion injury in obese rats
This study aimed to investigate the roles of melatonin on pyroptosis, necroptosis, and pro-inflammatory pathways occurring in the I/R brain of obese rats. Male Wistar rats were given a high-fat diet for 16 weeks to induce the obese condition, and then were divided into 4 groups: Sham-operated, I/R treated with vehicle, I/R treated with melatonin (10 mg/kg), and I/R treated with glycyrrhizic acid (10 mg/kg). All drugs were administered via intraperitoneal injection at the onset of reperfusion. The development of neurological deficits, cerebral infarction, histological changes, neuronal death, and glial cell hyperactivation ...
Source: Biochimica et Biophysica Acta - June 11, 2023 Category: Biochemistry Authors: Nuttapong Yawoot Jirakhamon Sengking Piyarat Govitrapong Chainarong Tocharus Jiraporn Tocharus Source Type: research

Probiotics in the times of COVID-19
Acta Biochim Pol. 2021 Aug 25. doi: 10.18388/abp.2020_5691. Online ahead of print.ABSTRACTThe time of COVID-19 pandemic focused the attention of scientist to recognise the complex medical symptoms of the disease, modes of infection and possible therapies. The organisms' response towards SARS-CoV-2 infection depends on many individual factors and the course of disease is described as unprecedented and complex. Numerous symptoms from the respiratory system, abnormalities in the gastrointestinal tract, stroke, liver damage and coagulopathy, among others, are accompanied by negative side effects of the pandemic lifestyle, incl...
Source: Acta Biochim Pol - August 25, 2021 Category: Biochemistry Authors: Joanna Je żewska-Frąckowiak Beata Łubkowska Ireneusz Sobolewski Piotr Mariusz Skowron Source Type: research

Effects of surface-deacetylated chitin nanofibers on non-alcoholic steatohepatitis model rats and their gut microbiota.
Abstract Nonalcoholic steatohepatitis (NASH), a more advanced form of nonalcoholic fatty liver disease (NAFLD), is associated with increased cardiovascular and liver-related mortality. Stroke-prone spontaneously hypertensive rats (SHRSP5/Dmcr) that are fed a high-fat and high-cholesterol diet develop hepatic lesions that are similar to those observed in human NASH pathology. We investigated the hepatic protective and antioxidant effects of surface-deacetylated chitin nanofibers (SDACNFs) that were administered to SHRSP5/Dmcr rats for 8 weeks. The administration of SDACNFs (80 mg/kg/day) resulted in a significa...
Source: International Journal of Biological Macromolecules - July 18, 2020 Category: Biochemistry Authors: Goto M, Iohara D, Michihara A, Ifuku S, Azuma K, Kadowaki D, Maruyama T, Otagiri M, Hirayama F, Anraku M Tags: Int J Biol Macromol Source Type: research

Critical review of nutrition, blood pressure and risk of hypertension through the lifecycle: do B vitamins play a role?
Abstract Hypertension is the leading cause of preventable mortality worldwide, contributing to over 9 million deaths per annum, predominantly owing to cardiovascular disease. The association of obesity, physical inactivity and alcohol with elevated blood pressure (BP) is firmly established. Weight loss or other dietary strategies, such as the Dietary Approaches to Stop Hypertension (DASH) diet, have been shown to be effective in lowering BP. Additionally, specific nutrients are recognised to contribute to BP, with higher sodium intake linked with an increased risk of hypertension, while potassium is associated wit...
Source: Biochimie - April 10, 2020 Category: Biochemistry Authors: Psara E, Pentieva K, Ward M, McNulty H Tags: Biochimie Source Type: research

S-Homocysteinylation effects on transthyretin: Worsening of cardiomyopathy onset
ConclusionsOur study demonstrated that S-homocysteinylation of the L55P-TTR mutant impairs protein stability, favouring the appearance of toxic monomers. Interestingly, S-homocysteinylation affected only mutant, not wt-TTR. Moreover, we also show that assemblies of S-homocysteinylated L55P-TTR impair cardiomyocytes functional parameters.General significanceOur study offers new insights on the negative impact of S-homocysteinylation on L55P-TTR stability, whose aggregation is considered the causative agent of a form of early-onset familial amyloid polyneuropathy and cardiomyopathy. Our results suggest that high homocysteine...
Source: Biochimica et Biophysica Acta (BBA) General Subjects - October 29, 2019 Category: Biochemistry Source Type: research

Acute myocardial infarction severity, complications, and mortality associated with lack of magnesium intake through consumption of desalinated seawater.
In conclusion, in post AMI patients, we found nonsignificant higher MACE and 1-year mortality with the use of DSW. PMID: 31556880 [PubMed - as supplied by publisher]
Source: Magnesium Research - September 23, 2019 Category: Biochemistry Authors: Shlezinger M, Amitai Y, Goldenberg I, Atar S, Shechter M Tags: Magnes Res Source Type: research

Proline ‐containing peptides—New insight and implications: A Review
AbstractThe family of regulatory proline ‐containing peptides (PCPs), also known as glyprolines, exhibit significant biological activity. The group of glyprolines includes Gly‐Pro (GP), Pro‐Gly‐Pro (PGP), cyclic Gly‐Pro (cGP), as well as PGP derivatives, for example, N‐acetylated PGP (N‐a‐PGP) and N‐methylated PGP (N‐m‐ PGP). PCPs are engaged in various biological processes including the proinflammatory neutrophil chemoattraction in lung diseases, inflammatory bowel diseases or ischemic stroke. Glyprolines have been also postulated to play an important role as atheroprotective and anticoagulant agents...
Source: BioFactors - August 19, 2019 Category: Biochemistry Authors: Magdalena Misiura, Wojciech Miltyk Tags: REVIEW ARTICLE Source Type: research

Biomarkers of blood cadmium and incidence of cardiovascular events in non-smokers: results from a population-based proteomics study
ConclusionsB-Cd in non-smokers was associated with eight potential plasma biomarkers of CVD and kidney injury. The results suggest pathways for the associations between B-Cd and CVD and kidney injury.
Source: Clinical Proteomics - May 14, 2019 Category: Biochemistry Source Type: research

Impaired function of cerebral parenchymal arterioles in experimental preeclampsia
Publication date: September 2018Source: Microvascular Research, Volume 119Author(s): Abbie C. Johnson, Marilyn J. CipollaAbstractPreeclampsia (PE), a dangerous hypertensive complication of pregnancy, is associated with widespread maternal vascular dysfunction. However, the effect of PE on the cerebral vasculature that can lead to stroke and cognitive decline is not well understood. We hypothesized that function of cortical parenchymal arterioles (PAs) would be impaired during PE. Using a high cholesterol diet to induce experimental PE in rats (ePE), we studied the function and structure of isolated and pressurized PAs supp...
Source: Microvascular Research - July 11, 2018 Category: Biochemistry Source Type: research

Reprint of: Marine OMEGA-3 fatty acids in the prevention of cardiovascular disease.
Abstract Omega-6 (ω6) and omega-3 (ω3) fatty acids are two classes of dietary polyunsaturated fatty acids derived from linoleic acid (18:2ω6) and α-linolenic acid (18:3ω3), respectively. Enzymatic metabolism of linoleic and α-linolenic acids generates arachidonic acid (20:4ω6) and eicosapentaenoic acid (20:5ω3; EPA), respectively, both of which are substrates for enzymes that yield eicosanoids with multiple and varying physiological functions. Further elongation and desaturation of EPA yields the 22-carbon fatty acid docosahexaenoic acid (22:6ω3; DHA). The main dietary source of EPA and DHA for human cons...
Source: Fitoterapia - April 12, 2018 Category: Biochemistry Authors: Mori TA Tags: Fitoterapia Source Type: research

Marine OMEGA-3 fatty acids in the prevention of cardiovascular disease.
Abstract Omega-6 (ω6) and omega-3 (ω3) fatty acids are two classes of dietary polyunsaturated fatty acids derived from linoleic acid (18:2ω6) and α-linolenic acid (18:3ω3), respectively. Enzymatic metabolism of linoleic and α-linolenic acids generates arachidonic acid (20:4ω6) and eicosapentaenoic acid (20:5ω3; EPA), respectively, both of which are substrates for enzymes that yield eicosanoids with multiple and varying physiological functions. Further elongation and desaturation of EPA yields the 22-carbon fatty acid docosahexaenoic acid (22:6ω3; DHA). The main dietary source of EPA and DHA for human cons...
Source: Fitoterapia - September 27, 2017 Category: Biochemistry Authors: Mori TA Tags: Fitoterapia Source Type: research