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Total 2719 results found since Jan 2013.

Life's Essential 8 and Risk of Stroke: A Prospective Community-Based Study
CONCLUSIONS: The CVH score as assessed by the Life's Essential 8 metrics significantly predicted future stroke risk and arterial stiffness status.PMID:37466001 | DOI:10.1161/STROKEAHA.123.042525
Source: Cancer Control - July 19, 2023 Category: Cancer & Oncology Authors: Shouling Wu Zhijun Wu Dongmei Yu Shuohua Chen Aitian Wang Anxin Wang Xiang Gao Source Type: research

Mediterranean diet cuts heart and stroke risk
Conclusion The results of this randomised controlled trial appear to confirm previous studies that there are benefits to following a Mediterranean diet. The trial has many strengths, including its large size, long period of follow-up, thorough assessment of medical outcomes (including reviewing medical records and having contact with the family doctor), and careful attempts to assess whether the diets were being followed. As this is a randomised controlled trial, it should also balance out other health and lifestyle differences between the groups that may influence cardiovascular risk. This avoids the limitations of m...
Source: NHS News Feed - February 26, 2013 Category: Consumer Health News Tags: Food/diet Heart/lungs Source Type: news

Caveolin-1 in stroke neuropathology and neuroprotection: a novel molecular therapeutic target for ischemic-related injury.
Abstract Cardiovascular disease and associated cerebral stroke are a global epidemic attributed to genetic and epigenetic factors, such as diet, life style and an increasingly sedentary existence due to technological advances in both the developing and developed world. There are approximately 5.9 million stroke-related deaths worldwide annually. Current epidemiological data indicate that nearly 16.9 million people worldwide suffer a new or recurrent stroke yearly. In 2014 alone, 2.4% of adults in the United States (U.S.) were estimated to experience stroke, which is the leading cause of adult disability and the fi...
Source: Current Vascular Pharmacology - February 5, 2018 Category: Drugs & Pharmacology Authors: Wang S, Head BP Tags: Curr Vasc Pharmacol Source Type: research

Post-stroke administration of omega-3 polyunsaturated fatty acids promotes neurovascular restoration after ischemic stroke in mice: Efficacy declines with aging.
Abstract Post-stroke treatment with omega-3 polyunsaturated fatty acids (n-3 PUFAs) may be a promising therapy in young animals but this has not been tested in aged subjects, a population at most risk of ischemic stroke. Herein we examined the therapeutic efficacy of n-3 PUFAs after distal middle cerebral artery occlusion (dMCAO) in young (10-12 weeks old) and aged (18 months old) mice. Post-ischemic mice were randomly assigned to 4 groups that received: 1) regular food with low content of n-3 PUFAs, 2) intraperitoneal docosahexaenoic acid (DHA, a major component of n-3 PUFAs) injections, 3) Fish oil (FO, cont...
Source: Neurobiology of Disease - September 12, 2018 Category: Neurology Authors: Jiang X, Suenaga J, Pu H, Wei Z, Smith AD, Hu X, Shi Y, Chen J Tags: Neurobiol Dis Source Type: research

Adherence to the Mediterranean diet and risk of stroke and stroke subtypes
AbstractSeveral meta-analyses including a small number of cohorts showed inverse associations between the Mediterranean Diet (MedDiet) and risk of stroke. However, it remains unclear whether such a relation varies by region of the study population or by major subtypes of stroke. We searched PubMed and EMBASE databases for relevant studies and we further included unpublished results from the Singapore Chinese Health Study (N = 57,078) and the Seguimiento Universidad de Navarra (SUN) study (N  =  12,670). We used a random-effects model to calculate summary relative risk (RR) with 95% confidence intervals (CI) of stro...
Source: European Journal of Epidemiology - March 1, 2019 Category: Epidemiology Source Type: research

Assessment of the risk factors in the daily life of stroke patients based on an optimized decision tree.
CONCLUSIONS: It is anticipated that the proposed system could help in reducing the risk, mortality, and disability of stroke, and provide clinical decision support for the treatment of stroke. PMID: 31045550 [PubMed - as supplied by publisher]
Source: Technology and Health Care - April 28, 2019 Category: Medical Devices Authors: Shao Z, Chen C, Chen W, Li W, Ren H, Chen W Tags: Technol Health Care Source Type: research

Pharmacological restoration of autophagy reduces hypertension-related stroke occurrence.
Abstract The identification of the mechanisms predisposing to stroke may improve its preventive and therapeutic strategies in patients with essential hypertension. The role of macroautophagy/autophagy in the development of hypertension-related stroke needs to be clarified. We hypothesized that a defective autophagy may favor hypertension-related spontaneous stroke by promoting mitochondrial dysfunction. We studied autophagy in the stroke-prone spontaneously hypertensive (SHRSP) rat, which represents a clinically relevant model of stroke associated with high blood pressure. We assessed autophagy, mitophagy and NAD+...
Source: Autophagy - November 2, 2019 Category: Cytology Authors: Forte M, Bianchi F, Cotugno M, Marchitti S, De Falco E, Raffa S, Stanzione R, di Nonno F, Chimenti I, Palmerio S, Pagano F, Petrozza V, Micaloni A, Madonna M, Relucenti M, Torrisi MR, Frati G, Volpe M, Rubattu S, Sciarretta S Tags: Autophagy Source Type: research

The Stroke-Induced Increase of Somatostatin-Expressing Neurons is Inhibited by Diabetes: A Potential Mechanism at the Basis of Impaired Stroke Recovery.
Abstract Type 2 diabetes (T2D) hampers recovery after stroke, but the underling mechanisms are mostly unknown. In a recently published study (Pintana et al. in Clin Sci (Lond) 133(13):1367-1386, 2019), we showed that impaired recovery in T2D was associated with persistent atrophy of parvalbumin+ interneurons in the damaged striatum. In the current work, which is an extension of the abovementioned study, we investigated whether somatostatin (SOM)+ interneurons are also affected by T2D during the stroke recovery phase. C57Bl/6j mice were fed with high-fat diet or standard diet (SD) for 12 months and subjected to 30...
Source: Cellular and Molecular Neurobiology - May 22, 2020 Category: Cytology Authors: Chiazza F, Pintana H, Lietzau G, Nyström T, Patrone C, Darsalia V Tags: Cell Mol Neurobiol Source Type: research

Exosomes derived from bone marrow mesenchymal stem cells harvested from type two diabetes rats promotes neurorestorative effects after stroke in type two diabetes rats.
CONCLUSIONS: T2DM-MSC-Exo treatment for stroke in T2DM rats promotes neurorestorative effects and improves functional outcome. Down regulation of miR-9 expression and increasing its target ABCA1 pathway may contribute partially to T2DM-MSC-Exo treatment induced white matter remodeling and anti-inflammatory responses. PMID: 32889008 [PubMed - as supplied by publisher]
Source: Experimental Neurology - August 31, 2020 Category: Neurology Authors: Venkat P, Zacharek A, Landschoot-Ward J, Wang F, Culmone L, Chen Z, Chopp M, Chen J Tags: Exp Neurol Source Type: research

Altered Properties of Neurons and Astrocytes and the Effects of Food Components in Stroke-Prone Spontaneously Hypertensive Rats
In this study, we obtained information using PubMed, ScienceDirect, and Web of Science. We searched for the functions of neurons and astrocytes and the molecular mechanism of ischemic stroke induction. We summarized the recent literature on the underlying mechanisms of stroke onset in SHRSP and the alleviating effects of typical food-derived phytochemical components. Neuronal death in SHRSP is induced by hypoxia-reoxygenation, suggesting the involvement of oxidative stress. Furthermore, the production of lactate, l-serine, and glial cell line-derived neurotrophic factor in SHRSP-derived astrocytes was reduced compared with...
Source: Journal of Cardiovascular Pharmacology - June 1, 2021 Category: Cardiology Tags: Review Article Source Type: research

Evaluation of an online intervention for improving stroke survivors ’ health-related quality of life: A randomised controlled trial
ConclusionsThe P2S online healthy lifestyle program improved stroke survivors ’ self-reported global ratings of HRQoL (as measured by EQ-VAS) at 6-month follow-up. Online platforms represent a promising tool to engage and support some stroke survivors. Trial registrationAustralian New Zealand Clinical Trials Registry ACTRN12617001205325.
Source: PLoS Medicine - April 19, 2022 Category: Internal Medicine Authors: Ashleigh Guillaumier Source Type: research

Dysregulated Hypothalamic –Pituitary–Adrenal Axis Is Associated With Increased Inflammation and Worse Outcomes After Ischemic Stroke in Diabetic Mice
Diabetic patients have larger infarcts, worse neurological deficits, and higher mortality rate after an ischemic stroke. Evidence shows that in diabetes, the hypothalamic–pituitary–adrenal (HPA) axis was dysregulated and levels of cortisol increased. Based on the role of the HPA axis in immunity, we hypothesized that diabetes-dysregulated stress response exacerbates stroke outcomes via regulation of inflammation. To test this hypothesis, we assessed the regulation of the HPA axis in diabetic mice before and after stroke and determined its relevance in the regulation of post-stroke injury and inflammation. Diabetes was ...
Source: Frontiers in Immunology - June 16, 2022 Category: Allergy & Immunology Source Type: research

The structure, processes, and outcomes of stroke rehabilitation in Ghana: A study protocol
ConclusionThe study protocol will provide a comprehensive overview of the structure, process, and outcomes of stroke rehabilitation in Ghana, incorporating both conventional and complementary treatment and rehabilitation into the stroke recovery journey. It will also inform clinical practice, with new insights on the experiences of stroke patients based on their choice of rehabilitation pathway.
Source: Frontiers in Neurology - August 24, 2022 Category: Neurology Source Type: research

Stroke risk with vegetarian, low-animal and high-animal diets: A systematic review and meta-analysis
CONCLUSIONS: Stroke risk is lower with more use of a vegetarian or low-animal diet but relatively higher with more use of a high-animal diet.PMID:36173214 | DOI:10.6133/apjcn.202209_31(3).0010
Source: Asia Pacific Journal of Clinical Nutrition - September 29, 2022 Category: Nutrition Authors: Yang Liu Linlin Zhu Dong Li Liankun Wang Han Tang Chunyuan Zhang Source Type: research