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Total 38 results found since Jan 2013.

GSE72278 A novel lineage of adipose tissue regulatory T cells controls obesity and insulin resistance
Contributors : Emilie Stolarczyk ; Charlotte Bailey ; Natividad Garrido-Mesa ; Paul Lavender ; Richard Jenner ; Graham Lord ; Jane HowardSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThe epidemic of obesity and its associated systemic metabolic complications continues to increase. Adipose tissue (AT)-associated T cells have been proposed to play an important role in the regulation of bodyweight and insulin sensitivity with a link to Th1 or Th2 lineage specification. A specific subset of regulatory T cells (TREGS) plays a critical and non-redundant role in controlling s...
Source: GEO: Gene Expression Omnibus - December 1, 2017 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Mus musculus Source Type: research

System biology approach intersecting diet and cell metabolism with pathogenesis of brain disorders
Publication date: Available online 27 July 2018Source: Progress in NeurobiologyAuthor(s): Fernando Gomez-Pinilla, Xia YangABSTRACTThe surge in meals high in calories has prompted an epidemic of metabolic disorders around the world such that the elevated incidence of obese and diabetic individuals is alarming. New research indicates that metabolic disorders pose a risk for neurological and psychiatric conditions including stroke, Alzheimer’s disease, Huntington’s disease, and depression, all of which have a metabolic component. These relationships are rooted to a dysfunctional interaction between molecular processes tha...
Source: Progress in Neurobiology - July 28, 2018 Category: Neuroscience Source Type: research

Probiotics improve gut microbiota dysbiosis in obese mice fed a high-fat or high-sucrose diet
The prevalence of obesity has been dramatically increasing globally over decades [1]. Obesity is caused by a complex interaction of genetic and environmental factors, and is also suggested to be the result of a long-term imbalance between energy intake and expenditure [2]. Calorie-rich foods that are high in fat or carbohydrates combining with sedentary lifestyles are the most common factors underlying the global obesity epidemic [3]. High-fat diets (HFD) increase adipose tissue and induce metabolic and cardiovascular disorders (such as atherosclerosis, type 2 diabetes, stroke, and hypertension [4, 5]), especially in those...
Source: Nutrition - October 10, 2018 Category: Nutrition Authors: Cheng Kong, Renyuan Gao, Xuebing Yan, Linsheng Huang, Huanlong Qin Source Type: research

Superbugs, Anti-Vaxxers Make WHO ’ s List Of 10 Global Health Threats
(CNN) — From climate change to superbugs, the World Health Organization has laid out 10 big threats to our global health in 2019. And unless these threats get addressed, millions of lives will be in jeopardy. Here’s a snapshot of 10 urgent health issues, according to the United Nations’ public health agency: Not vaccinating when you can One of the most controversial recent health topics in the US is now an international concern. “Vaccine hesitancy — the reluctance or refusal to vaccinate despite the availability of vaccines — threatens to reverse progress made in tackling vaccine-prevent...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - January 21, 2019 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News CNN Local TV Source Type: news

Impaired Activity of Ryanodine Receptors Contributes to Calcium Mishandling in Cardiomyocytes of Metabolic Syndrome Rats
Conclusion Principal findings of this work are that abnormal Ca2+ transient amplitude, contractile dysfunction; and impaired relaxation of MetS cardiomyocytes underlies intrinsic dysfunctional RyR2 and SERCA pump. Abnormal activity of RyRs was evidenced by its decreased ability to bind [3H]-ryanodine. Although the MetS condition does not modify RyR2 protein expression, its phosphorylation at Ser2814 is decreased, which impairs its capacity for activation during ECC. The dysfunctional RyRs, together with a decreased activity of SERCA pump due to decreased Thr17-PLN phosphorylation suggest a downregulation of CaMKII in MetS...
Source: Frontiers in Physiology - April 29, 2019 Category: Physiology Source Type: research

IJERPH, Vol. 16, Pages 2734: Glyphosate ’s Synergistic Toxicity in Combination with Other Factors as a Cause of Chronic Kidney Disease of Unknown Origin
IJERPH, Vol. 16, Pages 2734: Glyphosate’s Synergistic Toxicity in Combination with Other Factors as a Cause of Chronic Kidney Disease of Unknown Origin International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16152734 Authors: Sarath Gunatilake Stephanie Seneff Laura Orlando Chronic kidney disease of unknown etiology (CKDu) is a global epidemic. Sri Lanka has experienced a doubling of the disease every 4 or 5 years since it was first identified in the North Central province in the mid-1990s. The disease primarily affects people in agricultural regions who are missing the commonly k...
Source: International Journal of Environmental Research and Public Health - July 30, 2019 Category: Environmental Health Authors: Sarath Gunatilake Stephanie Seneff Laura Orlando Tags: Review Source Type: research

The role of nutraceuticals in prevention and treatment of hypertension: An updated review of the literature
Publication date: Available online 7 November 2019Source: Food Research InternationalAuthor(s): Samad Ghaffari, Neda RoshanravanAbstractHypertension (HTN) is a worldwide epidemic in both developed and developing countries. It is one of the leading causes of major health problems such as cardiovascular disease, stroke, and heart attack. In recent years, several studies have reported associations between specific dietary ingredients and improving HTN. Nutraceuticals are natural food components with pharmacological properties. Reports suggest that functional foods and nutraceutical ingredients might support patients to obtain...
Source: Food Research International - November 8, 2019 Category: Food Science Source Type: research

How to Keep Alzheimer ’s From Bringing About the Zombie Apocalypse
I tried to kill my father for years. To be fair, I was following his wishes. He’d made it clear that when he no longer recognized me, when he could no longer talk, when the nurses started treating him like a toddler, he didn’t want to live any longer. My father was 58 years old when he was diagnosed with Alzheimer’s disease. He took the diagnosis with the self-deprecating humor he’d spent a lifetime cultivating, constantly cracking jokes about how he would one day turn into a zombie, a walking corpse. We had a good 10 years with him after the diagnosis. Eventually, his jokes came true. Seven years ...
Source: TIME: Health - November 20, 2019 Category: Consumer Health News Authors: Jay Newton-Small Tags: Uncategorized Alzheimer's Disease Source Type: news

Our Diets Are Changing Because of the Coronavirus Pandemic. Is It for the Better?
The coronavirus pandemic has changed a lot about modern American life: how we work, socialize, and even how we eat. Dining out is a distant memory. But nutritionally, people weren’t exactly thriving in pre-pandemic America. “Before COVID-19 came along, it was increasingly clear that the diet quality and nutritional status of Americans was terrible,” says Dr. Walter Willett, professor of epidemiology and nutrition at Harvard T.H. Chan School of Public Health. More than 40% of U.S. adults are obese. After years of declines, heart disease death rates are on the rise again. So are rates of obesity-linked canc...
Source: TIME: Health - April 28, 2020 Category: Consumer Health News Authors: Mandy Oaklander Tags: Uncategorized COVID-19 Source Type: news

Daily intermittent fasting in mice enhances morphine-induced antinociception while mitigating reward, tolerance, and constipation
The opioid epidemic has plagued the United States with high levels of abuse and poor quality of life for chronic pain patients requiring continuous use of opioids. New drug discovery efforts have been implemented to mitigate this epidemic; however, new medications are still limited by low efficacy and/or high side effect and abuse potential. Intermittent fasting (IF) has recently been shown to improve a variety of pathological states, including stroke and neuroinflammation. Numerous animal and human studies have shown the benefits of IF in these disease states, but not in pain and opioid treatment. We thus subjected male a...
Source: Pain - September 24, 2020 Category: Anesthesiology Tags: Research Paper Source Type: research

Food as Prevention – Rising to Nutritional Challenges
Mothers and their children gather at a community nutrition centre in the little village of Rantolava, Madagascar, to learn more about a healthy diet. Credit: Alain Rakotondravony/IPSBy Gabriele RiccardiNAPLES, Italy, Nov 25 2020 (IPS) The risks factors contributing to the dramatic rise in non-communicable diseases (NCDs) in recent decades have been known for a long time but the Covid-19 pandemic has brutally exposed our collective failure to deal with them. Reporting on the findings of the latest Global Burden of Disease Study, The Lancet warns of a “perfect storm” created by the interaction of the highly infectious C...
Source: IPS Inter Press Service - Health - November 25, 2020 Category: International Medicine & Public Health Authors: Gabriele Riccardi Tags: Development & Aid Economy & Trade Featured Food Security and Nutrition Food Sustainability Global Headlines Health Humanitarian Emergencies Inequity Poverty & SDGs TerraViva United Nations Barilla Center for Food and Nutrition Foun Source Type: news

Hypertension: Do Inflammation and Immunity Hold the Key to Solving this Epidemic?
Circ Res. 2021 Apr 2;128(7):908-933. doi: 10.1161/CIRCRESAHA.121.318052. Epub 2021 Apr 1.ABSTRACTElevated cardiovascular risk including stroke, heart failure, and heart attack is present even after normalization of blood pressure in patients with hypertension. Underlying immune cell activation is a likely culprit. Although immune cells are important for protection against invading pathogens, their chronic overactivation may lead to tissue damage and high blood pressure. Triggers that may initiate immune activation include viral infections, autoimmunity, and lifestyle factors such as excess dietary salt. These conditions ac...
Source: Circulation Research - April 1, 2021 Category: Cardiology Authors: Meena S Madhur Fernando Elijovich Matthew R Alexander Ashley Pitzer Jeanne Ishimwe Justin P Van Beusecum David M Patrick Charles D Smart Thomas R Kleyman Justin Kingery Robert N Peck Cheryl L Laffer Annet Kirabo Source Type: research