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Hypertension: Do Inflammation and Immunity Hold the Key to Solving this Epidemic?
Circ Res. 2021 Apr 2;128(7):908-933. doi: 10.1161/CIRCRESAHA.121.318052. Epub 2021 Apr 1.ABSTRACTElevated cardiovascular risk including stroke, heart failure, and heart attack is present even after normalization of blood pressure in patients with hypertension. Underlying immune cell activation is a likely culprit. Although immune cells are important for protection against invading pathogens, their chronic overactivation may lead to tissue damage and high blood pressure. Triggers that may initiate immune activation include viral infections, autoimmunity, and lifestyle factors such as excess dietary salt. These conditions ac...
Source: Circulation Research - April 1, 2021 Category: Cardiology Authors: Meena S Madhur Fernando Elijovich Matthew R Alexander Ashley Pitzer Jeanne Ishimwe Justin P Van Beusecum David M Patrick Charles D Smart Thomas R Kleyman Justin Kingery Robert N Peck Cheryl L Laffer Annet Kirabo Source Type: research

Pediatric Lipid Disorders
Pediatr Ann. 2021 Mar;50(3):e105-e112. doi: 10.3928/19382359-20210218-01. Epub 2021 Mar 1.ABSTRACTCurrent scientific evidence has proven that atherosclerosis is a process that begins in childhood and tracks into adulthood, likely culminating in adverse cardiovascular events such as coronary artery disease, peripheral artery disease, and stroke. In addition, the obesity epidemic and increasing awareness of genetic lipid disorders has made the understanding and management of lipid disorders necessary for pediatricians. Childhood offers a unique opportunity for preventing, modifying, or eliminating risk factors and, in doing ...
Source: Pediatric Annals - May 26, 2021 Category: Pediatrics Authors: Scott Leopold Justin P Zachariah Source Type: research

Endothelial Cell CD36 Reduces Atherosclerosis and Controls Systemic Metabolism
Front Cardiovasc Med. 2021 Nov 23;8:768481. doi: 10.3389/fcvm.2021.768481. eCollection 2021.ABSTRACTHigh-fat Western diets contribute to tissue dysregulation of fatty acid and glucose intake, resulting in obesity and insulin resistance and their sequelae, including atherosclerosis. New therapies are desperately needed to interrupt this epidemic. The significant idea driving this research is that the understudied regulation of fatty acid entry into tissues at the endothelial cell (EC) interface can provide novel therapeutic targets that will greatly modify health outcomes and advance health-related knowledge. Dysfunctional ...
Source: Atherosclerosis - December 10, 2021 Category: Cardiology Authors: Umar R Rekhi Mohamed Omar Maria Alexiou Cole Delyea Linnet Immaraj Shokrollah Elahi Maria Febbraio Source Type: research

Anti-Diabesity Middle Eastern Medicinal Plants and Their Action Mechanisms
Evid Based Complement Alternat Med. 2022 Jul 18;2022:2276094. doi: 10.1155/2022/2276094. eCollection 2022.ABSTRACTOver the last four decades, the escalation in diabetes and obesity rates has become epidemic all over the world. Diabesity describes the strong link between T2D and obesity. It correlates deeper with the elevated risks of developing cardiovascular disease hypertension, stroke, and several malignancies. Therapeutic usage of medicinal plants and natural products in the treatment of diabetes and obesity has long been known to physicians of Greco-Arab and Islamic medicine. Improved versions of their abundant medici...
Source: Evidence-based Complementary and Alternative Medicine - July 28, 2022 Category: Complementary Medicine Authors: Bashar Saad Abdalsalam Kmail Sameena Z H Haq Source Type: research

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