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Possible link between diabetes and cerebrovascular disease
Midlife diabetes could raise risk of stroke by 30% Related items fromOnMedica Experts warn of heart risks for people with diabetes Diabetes growth will cause surge in cardiovascular disease Coronary heart disease remains UK ’s biggest killer Chocolate could prevent some CVD events Dementia risk rises for middle-age abstainers and heavy drinkers
Source: OnMedica Latest News - June 5, 2019 Category: UK Health Source Type: news

A Comparison of Three Different Bioinformatics Analyses of the 16S –23S rRNA Encoding Region for Bacterial Identification
Conclusion The higher resolution at the species level identification provided by 16S–23S rRNA encoding region NGS makes its use in routine diagnostic microbiology potentially attractive. Particularly, data analysis is one of the most important steps of a diagnostic workflow, which requires an optimal pipeline for the interpretation of the sequencing data in a short time. This study demonstrates that de novo assembly and subsequent BLASTN analysis using an in-house developed database compared to OTU clustering and mapping approaches is the most accurate and fastest approach for identification of bacterial pathogens....
Source: Frontiers in Microbiology - April 15, 2019 Category: Microbiology Source Type: research

Plant-Derived Alkaloids: The Promising Disease-Modifying Agents for Inflammatory Bowel Disease
Conclusion This paper summarizes the current findings regarding the anti-colitis activity of plant-derived alkaloids and shows how these alkaloids exhibit significant and beneficial effects in alleviating colonic inflammation. These natural alkaloids are not only promising agents for IBD treatment but are also components for developing new wonder drugs. However, the underlying molecular mechanisms or toxicological evaluation of most plant-derived alkaloids still require much scientific research, and their actual efficacies for IBD patients have not been verified well in field research. Thus, further clinical trials to elu...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

Chocolate and risk of chronic disease: a systematic review and dose-response meta-analysis
ConclusionChocolate consumption is not related to risk for several chronic diseases, but could have a small inverse association with CHD and stroke. Our findings are limited by very low  or low credibility of evidence, highlighting important uncertainty for chocolate–disease associations.
Source: European Journal of Nutrition - February 25, 2019 Category: Nutrition Source Type: research

Total polyphenol intake, polyphenol subtypes and incidence of cardiovascular disease: The SUN cohort study
ConclusionThe intake of flavonoids showed an inverse association with risk of cardiovascular events in a prospective cohort of Spanish middle-aged adult university graduates.Registration number for clinical trialsNCT02669602 in Clinical Trials.
Source: Nutrition, Metabolism and Cardiovascular Diseases - October 5, 2018 Category: Nutrition Source Type: research

High blood pressure: Eat this type of chocolate to slash hypertension
HIGH blood pressure, or hypertension, levels could be lowered through dietary changes and exercise. Keeping blood pressure levels low is important as this could reduce the risk of early death from stroke or heart disease. Eating this could help reduce high blood pressure levels.
Source: Daily Express - Health - July 31, 2018 Category: Consumer Health News Source Type: news

High blood pressure: Consuming this type of chocolate could slash hypertension
HIGH blood pressure, or hypertension, levels could be lowered through dietary changes and exercise. Keeping blood pressure levels low is important as this could reduce the risk of early death from stroke or heart disease. Eating this could help reduce high blood pressure levels.
Source: Daily Express - Health - July 31, 2018 Category: Consumer Health News Source Type: news

Chocolate intake and heart disease and stroke in the Women's Health Initiative: a prospective analysis
ConclusionWe observed no association between chocolate intake and risk of CHD, stroke, or both combined in participants free of pre-existing major chronic disease. The relation for both combined was modified by age, with a significant positive linear trend and an increased risk in the highest quintile of chocolate consumption among women age<65 y. This trial was registered at clinicaltrials.gov as NCT03453073.
Source: American Journal of Clinical Nutrition - June 21, 2018 Category: Nutrition Source Type: research

Chocolate intake and heart disease and stroke in the Women's Health Initiative: a prospective analysis.
Conclusion: We observed no association between chocolate intake and risk of CHD, stroke, or both combined in participants free of pre-existing major chronic disease. The relation for both combined was modified by age, with a significant positive linear trend and an increased risk in the highest quintile of chocolate consumption among women age <65 y. This trial was registered at clinicaltrials.gov as NCT03453073. PMID: 29931040 [PubMed - as supplied by publisher]
Source: The American Journal of Clinical Nutrition - June 21, 2018 Category: Nutrition Authors: Greenberg JA, Manson JE, Neuhouser ML, Tinker L, Eaton C, Johnson KC, Shikany JM Tags: Am J Clin Nutr Source Type: research

A Man Got ‘Thunderclap Headaches’ After Eating the World’s Hottest Pepper
This article originally appeared on Health.com
Source: TIME: Health - April 10, 2018 Category: Consumer Health News Authors: Amanda Macmillan / Health.com Tags: Uncategorized Diet/Nutrition healthytime onetime Source Type: news

Impact of Coffee and Cacao Purine Metabolites on Neuroplasticity and Neurodegenerative Disease.
Abstract Increasing evidence suggests that regular consumption of coffee, tea and dark chocolate (cacao) can promote brain health and may reduce the risk of age-related neurodegenerative disorders. However, the complex array of phytochemicals in coffee and cacao beans and tea leaves has hindered a clear understanding of the component(s) that affect neuronal plasticity and resilience. One class of phytochemicals present in relatively high amounts in coffee, tea and cacao are methylxanthines. Among such methylxanthines, caffeine has been the most widely studied and has clear effects on neuronal network activity, pro...
Source: Neurochemical Research - February 8, 2018 Category: Neuroscience Authors: Camandola S, Plick N, Mattson MP Tags: Neurochem Res Source Type: research

Chocolate intake in pre-menopausal women
We thank Dr. Mattioli and Dr. Farinetti for their letter regarding our article “Chocolate consumption and risk of stroke among men and women: A large population-based, prospective cohort study” [1]. We are delighted that they are interested in the paper and think our finding is of importance with a view on stroke prevention.
Source: Atherosclerosis - December 19, 2017 Category: Cardiology Authors: Jia-Yi Dong, Hiroyasu Iso Tags: Correspondence Source Type: research

Stroke and food groups: an overview of systematic reviews and meta-analyses.
CONCLUSIONS: The current overview provided a high level of evidence to support the beneficial effect of specific foods on stroke outcome. Clinicians and policy makers could inform clinical practice and policy based on this overview. PMID: 29143697 [PubMed - as supplied by publisher]
Source: Public Health Nutrition - November 16, 2017 Category: International Medicine & Public Health Authors: Deng C, Lu Q, Gong B, Li L, Chang L, Fu L, Zhao Y Tags: Public Health Nutr Source Type: research

Eating a small amount of chcolate reduces risk of stroke
Experts from Boston found a regular chocolate treat slashes our risk of an abnormal heart rhythm linked with stroke by 20%. It contains flavanols which promote healthy blood vessel function.
Source: the Mail online | Health - August 1, 2017 Category: Consumer Health News Source Type: news

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