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Total 204 results found since Jan 2013.

Intracranial Carotid Calcification on Cranial Computed Tomography: Visual Scoring Methods, Semiautomated Scores, and Volume Measurements in Patients With Stroke Clinical Sciences
Conclusions— Visual scores correlate highly with quantitative intracranial internal carotid artery calcification measures, with excellent observer agreements. Visual intracranial internal carotid artery scores could be a rapid and practical method for epidemiological studies.
Source: Stroke - August 24, 2015 Category: Neurology Authors: Subedi, D., Zishan, U. S., Chappell, F., Gregoriades, M.-L., Sudlow, C., Sellar, R., Wardlaw, J. Tags: Cerebrovascular disease/stroke, CT and MRI, Carotid Stenosis, Risk Factors for Stroke Clinical Sciences Source Type: research

Coronary Artery Calcium Score Improves the Prediction of Occult Coronary Artery Stenosis in Ischemic Stroke Patients Stroke
BackgroundCoronary heart disease is a significant cause of morbidity and mortality in stroke patients. The coronary artery calcium score (CACS) has emerged as a robust and noninvasive predictor of coronary events. We assessed the predictive ability of CACS to identify stroke patients with severe (≥50%) occult coronary artery stenosis in a stroke/transient ischemic attack population, in addition to the PRECORIS score, based on Framingham Risk Score and presence of cervicocephalic artery stenosis, which was derived and validated for that purpose.Methods and ResultsWe enrolled consecutive patients aged 45 to 75 years refer...
Source: JAHA:Journal of the American Heart Association - October 30, 2016 Category: Cardiology Authors: Beigneux, Y., Sablayrolles, J.-L., Varenne, O., Mas, J.-L., Calvet, D. Tags: Computerized Tomography (CT), Ischemic Stroke, Transient Ischemic Attack (TIA), Atherosclerosis, Coronary Artery Disease Original Research Source Type: research

Postreperfusion Blood Pressure Variability After Endovascular Thrombectomy Affects Outcomes in Acute Ischemic Stroke Patients With Poor Collateral Circulation
Conclusion: Postreperfusion BP management by decreasing BPV may have influence on improving clinical outcome in cases of poor collateral circulation among patients achieving successful recanalization after ERT. Introduction Endovascular recanalization therapy (ERT) has been adopted as standard stroke care in patients with acute ischemic stroke (1–6). Time to recanalization and degree of recanalization are the most important predictors of clinical outcomes after ERT (7). Before recanalization, an effort to reduce the time from symptom onset to reperfusion is critical for penumbral salvage. After recanalization...
Source: Frontiers in Neurology - April 11, 2019 Category: Neurology Source Type: research

Shengui Sansheng San Ameliorates Cerebral Energy Deficiency via Citrate Cycle After Ischemic Stroke
Conclusion In summary, SSS extraction significantly ameliorates cerebral energy metabolism via boosting citrate cycle, which mainly embodies the enhancements of blood glucose concentration, glucose and lactate transportation and glucose utilization, as well as the regulations of relative enzymes activities in citrate cycle. These ameliorations ultimately resulted in numerous ATP yield after stroke, which improved neurological function and infarcted volume. Collectively, it suggests that SSS extraction has exerted advantageous effect in the treatment of cerebral ischemia. Ethics Statement All animal operations were accor...
Source: Frontiers in Pharmacology - April 22, 2019 Category: Drugs & Pharmacology Source Type: research

Paramedics may be best first line of defense in treating stroke patients
This study involved an unprecedented cooperative effort of paramedics in the field and emergency physicians serving as investigators,” said Dr. Sidney Starkman, co-principal investigator and co-director of the UCLA Stroke Center. “Through this study we were able to instill permanently in everyone’s mind the idea that ‘time is brain.’ We believe this represents a paradigm shift in the treatment of stroke and potentially numerous other neurological conditions,” said Starkman, who also is professor of emergency medicine and neurology at the Geffen School. “We demonstrated that paramedics not only are eager to pr...
Source: UCLA Newsroom: Health Sciences - February 5, 2015 Category: Universities & Medical Training Source Type: news

Quick magnesium treatment fails to improve stroke outcomes, but study has silver lining
In the first study of its kind, a consortium led by UCLA physicians found that giving stroke patients intravenous magnesium within an hour of the onset of symptoms does not improve stroke outcomes.   However, the 8-year trial did find that with the help of paramedics in the field, intravenous medications can frequently be administered to stroke victims within that so-called "golden hour," during which they have the best chance to survive and avoid debilitating, long-term neurological damage.   The latter finding is a "game-changer," said Dr. Jeffrey Saver, director of the UCLA Stroke Center and a professor of ...
Source: UCLA Newsroom: Health Sciences - February 13, 2014 Category: Universities & Medical Training Source Type: news

Calcium supplements linked to post-stroke dementia in women
Conclusion The media paint this as a troubling study for older women who take calcium to strengthen their bones. However the small size of the study (only 98 women took calcium supplements, and only 14 of those got dementia) and its observational nature mean that we cannot rely on the results. As the researchers mention, it is possible that those taking supplements were less healthy than those that didn't in some unmeasured way. Further research may improve our confidence in these results. Broken bones are not a trivial matter for older people – a broken hip can be the difference between being able to live independentl...
Source: NHS News Feed - August 18, 2016 Category: Consumer Health News Tags: Neurology Medication Older people Source Type: news

Thoracic Aortic < sup > 18 < /sup > F-Sodium Fluoride Activity and Ischemic Stroke in Patients With Established Cardiovascular Disease
CONCLUSIONS: In patients with established cardiovascular disease, thoracic aortic 18F-sodium fluoride activity is associated with the progression of atherosclerosis and future ischemic stroke. Arterial 18F-sodium fluoride activity identifies localized areas of atherosclerotic disease activity that are directly linked to disease progression and downstream regional clinical atherothrombotic events. (DIAMOND - Dual Antiplatelet Therapy to Reduce Myocardial Injury [DIAMOND], NCT02110303; Study Investigating the Effect of Drugs Used to Treat Osteoporosis on the Progression of Calcific Aortic Stenosis [SALTIRE II], NCT02132026; ...
Source: Atherosclerosis - February 20, 2022 Category: Cardiology Authors: Alexander J Fletcher Yong Y Tew Evangelos Tzolos Shruti S Joshi Jakub Kaczynski Jennifer Nash Samuel Debono Maria Lembo Jacek Kwiecinski Rong Bing Maaz B J Syed Mhairi K Doris Edwin J R van Beek Alistair J Moss William S Jenkins Niki L Walker Nikhil V Jos Source Type: research

Intracranial Spotty Calcium Predicts Recurrent Stroke in Patients with Symptomatic Intracranial Atherosclerotic Stenosis
ConclusionIn patients with symptomatic ICAS, intracranial spotty calcium is an independent predictor of recurrent ischemic stroke, which will further facilitate risk stratification and suggest that more aggressive treatment should be considered for these patients.
Source: Klinische Neuroradiologie - June 7, 2023 Category: Radiology Source Type: research

Investigation of Computed-Tomography Based Predictors of Acute Stroke Related to Transcatheter Aortic Valve Replacement: Aortic Wall Plaque Thickness Might be a Predictive Parameter of Stroke.
CONCLUSION: Aortic wall plaque thickness measured by contrast-enhanced CT might be a predictive parameter of strokes that occur within 48 hours after TAVR. PMID: 32005786 [PubMed - in process]
Source: The Journal of Invasive Cardiology - February 3, 2020 Category: Cardiology Tags: J Invasive Cardiol Source Type: research

Prognostic Value of Coronary CT Angiography for Predicting Poor Cardiac Outcome in Stroke Patients without Known Cardiac Disease or Chest Pain: The Assessment of Coronary Artery Disease in Stroke Patients Study.
CONCLUSION: Assessment of stenosis degree and plaque type using CCTA provided additional prognostic value over CACS and FRS to risk stratify stroke patients without prior history of CAD better. PMID: 32691541 [PubMed - in process]
Source: Korean Journal of Radiology - July 23, 2020 Category: Radiology Tags: Korean J Radiol Source Type: research

Middle Cerebral Artery Calcification: Association With Ischemic Stroke
This study retrospectively included 354 subjects with ischemic stroke in the MCA territory and 1518 control subjects who underwent computed tomography (CT) of the brain. We recorded major known risk factors for ischemic stroke, including age, gender, hypertension, diabetes mellitus, smoking, hyperlipidemia, and obesity, along with the MCA calcium burden, measured with the Agatston calcium scoring method. Univariate and modified logistic regression analyses were performed to examine the association between the MCA calcification and ischemic stroke. The univariate analyses showed significant associations of ischemic stroke w...
Source: Medicine - December 1, 2015 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Coronary Calcium Score for the Prediction of Asymptomatic Coronary Artery Disease in Patients With Ischemic Stroke
Conclusion: The necessity for CAC evaluation could be determined based on the presence of risk factors and significant stenosis of the cervicocephalic arteries. CAC evaluation may be useful for screening for severe CAD in stroke patients.
Source: Frontiers in Neurology - March 26, 2020 Category: Neurology Source Type: research

Ischemic Stroke: Measurement of Intracranial Artery Calcifications Can Improve Prediction of Asymptomatic Coronary Artery Disease Neuroradiology
Conclusion: The IAC scores quantified by using unenhanced CT correlate significantly with coronary calcium scores and may serve as an independent predictor of asymptomatic CAD in patients with ischemic stroke. © RSNA, 2013
Source: Radiology - August 22, 2013 Category: Radiology Authors: Ahn, S. S., Nam, H. S., Heo, J. H., Kim, Y. D., Lee, S.-K., Han, K. H., Choi, B. W., Kim, E. Y. Tags: Neuroradiology, Vascular Imaging Source Type: research

Relationship Between Sleep Apnea and Coronary Artery Calcium in Patients With Ischemic Stroke
Conclusion: Our findings indicate a relationship between coronary atherosclerotic burden measured by the CAC score and the severity of sleep apnea. Performing polysomnography could be useful for investigating the severity of hidden coronary artery disease among these patients.
Source: Frontiers in Neurology - July 30, 2019 Category: Neurology Source Type: research