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Source: Heart, Lung and Circulation

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Total 240 results found since Jan 2013.

Elevated Plasma Angiotensin Converting Enzyme 2 (ACE2) Activity is Associated with Embolic Stroke of Undetermined Source
Background: ACE2 activity levels correlate with adverse left atrial remodelling in patients with atrial fibrillation (AF). Several biochemical and structural markers have been associated with embolic stroke of undetermined source (ESUS). We investigated the relationship between ACE2 activity and ESUS.
Source: Heart, Lung and Circulation - June 23, 2019 Category: Cardiology Authors: J. Sajeev, L. Burrell, H. Dewey, J. Kalman, B. Chou, T. Frost, S. Patel, L. Roberts, J. Cooke, A. Koshy, M. Gould, J. Ngoh, R. Denver, A. Teh Tags: 377 Source Type: research

Low levels of IgG Antibodies Against Malondialdehyde Conjugated with Human Serum Albumin, Associates with Higher Risk of Stroke in 60-year-old males
Malondialdehyde (MDA) is by-product of lipid peroxidation as in oxidized low-density lipoprotein. We here studied the association between IgG antibodies against Malondialdehyde (anti-MDA) and risk of cardiovascular events such as stroke, angina and myocardial infraction in this cohort. Low levels of IgG anti-MDA conjugated with human serum albumin concentrations were measured by Enzyme Linked Immunosorbent Assay (ELISA). The association between IgG anti-MDA. 84 month's follow-ups were conducted in Stockholm County for 60-year-old men and women in which the risk factors associated in the screening of cardiovascular events f...
Source: Heart, Lung and Circulation - June 23, 2019 Category: Cardiology Authors: S. Samal, M. Vikstr öm, J. Frostegård Tags: 111 Source Type: research

A Retrospective Analysis of Remote Monitoring Alerts for Atrial Fibrillation: Implications for Anticoagulation
Background: Remote monitoring (RM) allows for the early detection of both subclinical and symptomatic atrial fibrillation (AF), providing an opportunity to evaluate the need for anticoagulation for stroke prevention.
Source: Heart, Lung and Circulation - June 23, 2019 Category: Cardiology Authors: C. O'Shea, A. Brooks, K. Campbell, J. Hendriks, D. Lau, P. Sanders Tags: 340 Source Type: research

Blood Pressure Variability and Cerebral Small Vessel Disease: a Systematic Review, Meta-Analysis and Meta-Regression
The objective of this study was to systematically review the literature and quantify the bidirectional association between intra-individual BPV and cerebral small vessel disease (CSVD).
Source: Heart, Lung and Circulation - June 23, 2019 Category: Cardiology Authors: P. Tully Tags: 045 Source Type: research

Insight into Differing Exercise Stroke Volume Mechanics between Endurance Athletes and Non-Athletes
Background: In healthy subjects, stroke volume (SV) and heart rate (HR) combine to augment cardiac output. The degree to which SV can augment, compensating for abnormally low HR during exercise is unknown.
Source: Heart, Lung and Circulation - June 23, 2019 Category: Cardiology Authors: F. Sully, D. Flannery, K. Janssens, L. Wright, A. La Gerche Tags: 282 Source Type: research

Comparison of Echocardiographic Parameters of Left Atrial and Ventricular Function between Young Stroke vs Lone Atrial Fibrillation vs Healthy Controls
Background: Stroke is one of Australia's leading causes of morbidity and mortality with a significant percentage classified as cryptogenic. The nature and aetiology of cryptogenic stroke remains elusive, with a proportion believed to be cardio-embolic secondary to subclinical paroxysmal atrial fibrillation (AF). We aim to gain mechanistic insights into the pathophysiology of cryptogenic stroke in the young by comparing cardiac structural and functional differences in patients with young stroke, lone AF and healthy controls.
Source: Heart, Lung and Circulation - June 23, 2019 Category: Cardiology Authors: A. Bhat, S. Khanna, H. Chen, G. Gan, R. MacIntyre, T. Tan Tags: 254 Source Type: research

Trends in the Use of Warfarin and Novel Oral Anticoagulants in Australia, 2013 to 2017
Background: In 2013, novel oral anticoagulants (NOACs) were added to the PBS as alternatives to warfarin for stroke prevention in atrial fibrillation (AF). Aim of this study is to examine changes in the use of oral anticoagulants (OACs) since the introduction of NOACs.
Source: Heart, Lung and Circulation - June 23, 2019 Category: Cardiology Authors: A. Dina, T. Akindele Tags: 231 Source Type: research

The role of Holter Monitor in the Detection of Atrial Fibrillation in Transient Ischaemic Attack and Acute Ischaemic Stroke
Background: Ischaemic stroke of cardioembolic origin is associated with profound morbidity and mortality, of which atrial fibrillation (AF) accounts for a significant proportion. Holter monitoring remains the first line investigation in identifying patients with underlying AF in stroke patients.
Source: Heart, Lung and Circulation - June 23, 2019 Category: Cardiology Authors: Q. Tran, A. O ’Loughlin Tags: 227 Source Type: research

First Australian Experience with Total Thoracoscopic Left Atrial Appendage Occlusion with Atriclip PRO2 device
We describe the first Australian series of totally thoracoscopic external LAA occlusion with the Atriclip PRO2TM device.
Source: Heart, Lung and Circulation - June 23, 2019 Category: Cardiology Authors: P. Joshi, P. Sadlier, R. Weerasooriya, D. Playford Tags: 466 Source Type: research

Nurse-Led Protocol-Based Atrial Fibrillation Clinic Associated with High Quality Care for Patients
We report the results of an ongoing nurse-led protocol based AF clinic.
Source: Heart, Lung and Circulation - June 23, 2019 Category: Cardiology Authors: N. Ariyarathna, J. Raman Srinivasan, C. Hastie, C. McCallum, M. McManus, V. Moosavi, Q. Yang, B. Nkoane-Kelaeng, C. Olivia, A. Farshid Tags: 206 Source Type: research

New Atrial Fibrillation after Non-Cardiac Surgery Increases Risk of Stroke: Results from a Meta-Analysis
Introduction: New-onset post-operative atrial fibrillation (POAF) following non-cardiac surgery (NCS) has been associated with increased length of stay, morbidity and mortality. However, it is unclear whether POAF increases long-term risk of stroke, which may have implications for anticoagulation use in POAF.
Source: Heart, Lung and Circulation - June 23, 2019 Category: Cardiology Authors: A. Koshy, V. Thijs, A. Teh, J. Sajeev, H. Lim, H. Han, L. Weinberg, P. Gow, O. Farouque Tags: 200 Source Type: research

Is There Seasonal Variation in the Incidence Of Atrial Fibrillation?
Cardiovascular events seem to follow a diurnal and seaonal pattern. The incidence of stroke based on hospital casualty presentations is also seasonal. To determine whether atrial fibrillation also follows a seasonal pattern we analysed the remote monitoring data of 53 of our patients with dual chamber pacemakers. Daily transmission data were examined for mode switching, AF burden, activity sensor rate and % V pacing between October 2017 to October 2018.
Source: Heart, Lung and Circulation - June 23, 2019 Category: Cardiology Authors: L. Davis, L. Coverdale, M. Johnston, N. Prentice Tags: 196 Source Type: research

Is Incorrect Anti-Coagulation Dosing Contributing to Ischaemic Stroke Burden? A Retrospective Single-Centre Study from Regional New South Wales, Australia
Background: Atrial fibrillation (AF) contributes to 30% of ischaemic stroke presentations. Low doses of anti-coagulants are often prescribed to prevent stroke but ameliorate bleeding risk.
Source: Heart, Lung and Circulation - June 23, 2019 Category: Cardiology Authors: P. Bamford, M. Ray, S. Cheruvu, M. Parkinson, C. Said, J. Trappel, J. Rogers Tags: 195 Source Type: research

Gender Difference in Clinical Outcomes after Percutaneous Left Atrial Appendage Closure in Patients with Atrial Fibrillation
Background: Females with atrial fibrillation (AF) could have a greater risk for ischemic stroke and systemic emboli compared with males. However, the incidence of these events by gender after percutaneous left atrial appendage (LAA) closure is not clear.
Source: Heart, Lung and Circulation - June 23, 2019 Category: Cardiology Authors: S. Iwai, S. Worthley, P. Sanders, G. Young Tags: 186 Source Type: research

Qualifying Event Proximity, Cardiovascular Risk, and Benefit of Empagliflozin in Patients with Type 2 Diabetes and Stable Atherosclerosis in the EMPA-REG OUTCOME Trial
Background: In type 2 diabetes, the temporal proximity of an atherosclerotic cardiovascular (CV) event can impact prognosis, but whether timing influences sodium glucose co-transporter 2 inhibitor effects is unknown. We explored the association of time from last qualifying CV event before randomization (myocardial infarction [MI], stroke, coronary artery disease or peripheral arterial disease) with CV outcomes and benefit of empagliflozin (EMPA) in EMPA-REG OUTCOME.
Source: Heart, Lung and Circulation - June 23, 2019 Category: Cardiology Authors: J. Udell, B. Zinman, C. Wanner, M. von Eynatten, J. George, I. Zwiener, S. Lund, S. Hantel, D. Fitchett Tags: 416 Source Type: research