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Source: Heart, Lung and Circulation
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Total 240 results found since Jan 2013.
Anticoagulation for Non-valvular AF in the Elderly—An Audit
Introduction: Atrial fibrillation (AF) affects 5% of those above 75 . Anticoagulation results in a 67% relative risk reduction of ischaemic stroke and is recommended for patients with a CHA2DS2-VASc score of more than one provided there are no contraindications .
Source: Heart, Lung and Circulation - June 24, 2013 Category: Cardiology Authors: V. Mathavan, C. Nunn Tags: Abstracts Source Type: research
Diagnosis of Atrial Fibrillation Using the Pulsecor Cardioscope Blood Pressure Device
Background: Atrial fibrillation (Afib) may first be diagnosed only after presentation with heart failure or stroke. Identification of Afib by non-medical staff when measuring blood pressure (BP) may improve its’ detection in asymptomatic patients in primary care. The Pulsecor CardioScope is a user friendly automated sphygmomanometer previously validated for estimating central BP. Analysis of beat-to-beat variation in the pulse wave amplitude or RR interval could also be used to diagnose Afib.
Source: Heart, Lung and Circulation - June 24, 2013 Category: Cardiology Authors: T. Oh, A. Lowe, A. Lin, R. Stewart Tags: Abstracts Source Type: research
PFO Closure – The Christchurch Experience
We report the safety and efficacy of PFO closure in Christchurch.
Source: Heart, Lung and Circulation - June 24, 2013 Category: Cardiology Authors: P.J.P. Balfour, D. Murphy, R.W. Troughton, J.W.H. Blake Tags: Abstracts Source Type: research
Bleeding Events Associated with Novel Anticoagulants: A Case Series
Until lately warfarin was the only valuable oral anticoagulant in stroke reduction in high risk cases with non valvular atrial fibrillation (NVAF). Although with warfarin the rate of stroke reduced notably, the major concern is the risk of serious bleeding and difficulty of establishing and maintaining the international normalised ratio (INR) within the therapeutic range. With the development of the novel anticoagulants we now have for the first time since the innovation of Warfarin feasible alternatives to it to decrease stroke rates in high risk patients with NVAF. To diminish adverse bleeding events with the novel antic...
Source: Heart, Lung and Circulation - May 30, 2013 Category: Cardiology Authors: Sam Mirzaee, Tara Thi Thien Tran, John Amerena Tags: Clinical Spotlights Source Type: research
Non-Bacterial Aortic Valve Vegetation
A 31 year-old man was referred to our hospital for management of a 2cm×2.3cm lesion seen on the left coronary cusp of his aortic valve on transoesophageal echocardiogram (, panel A and B). There was a mild gradient across the aortic valve (mean gradient of 17mmHg) and some mild eccentric aortic regugitation as a consequence of the lesion. Echocardiography had been performed after an ejection systolic murmur was noted by his local medical officer. He denied symptoms of infection or congestive cardiac failure. Routine initial investigations were unremarkable. Multiple sets of blood cultures were negative. Urgent antiphospho...
Source: Heart, Lung and Circulation - May 28, 2013 Category: Cardiology Authors: Sarah Gutman, Andrew Burns Tags: Images Source Type: research
Decreased Stroke When Avoiding Aortic Manipulation – An Updated Meta-Analysis
Introduction: Neurological injury is a devastating complication of coronary artery bypass grafting (CABG) and is its ‘Achilles Heel’ when compared to percutaneous coronary intervention (PCI). The mechanisms of stroke after CABG are multifactorial but includes embolisation of calcified atherosclerotic plaque from the ascending aorta.
Source: Heart, Lung and Circulation - May 23, 2013 Category: Cardiology Authors: J.J.B. Edelman, T.D. Yan, M.K. Wilson, P.G. Bannon, M.P. Vallely Tags: Abstracts Source Type: research
The Morbidity and Mortality Outcomes of Indigenous Australian Peoples after Isolated Coronary Artery Bypass Graft Surgery: The Influence of Geographic Remoteness
Conclusion: Indigenous Australian peoples were at greater risk for prolonged ventilation and combined morbidity outcome, and experienced poorer survival in the longer term. Higher mortality risk among Indigenous Australians was evident even after controlling for remoteness and accessibility to services.
Source: Heart, Lung and Circulation - April 1, 2013 Category: Cardiology Authors: Anil Prabhu, Phillip J. Tully, Jayme S. Bennetts, Sigrid C. Tuble, Robert A. Baker Tags: Original Articles Source Type: research
Outcomes and Excess Costs among Patients with Cardiovascular Disease
Conclusions: Patients with PAD had the highest likelihood of vascular interventions and CV death, and incurred high excess costs in comparison to other groups.
Source: Heart, Lung and Circulation - March 18, 2013 Category: Cardiology Authors: Zanfina Ademi, Danny Liew, Ella Zomer, Alexandra Gorelik, Bruce Hollingsworth, Ph. Gabriel Steg, Deepak L. Bhatt, Christopher M. Reid Tags: Original Articles Source Type: research
Outcomes of Surgical Aortic Valve Replacement in Octogenarians
Conclusions: Surgical AVR yields excellent short- and long-term outcomes for potentially high-risk, elderly patients.
Source: Heart, Lung and Circulation - February 19, 2013 Category: Cardiology Authors: Rebecca S. Harris, Tristan D. Yan, Deborah Black, Paul G. Bannon, Matthew S. Bayfield, P. Nicholas Hendel, Michael K. Wilson, Michael P. Vallely Tags: Original Articles Source Type: research
Differences in Morphology of Fibrin Clots Induced with Thrombin and Ferric Ions and Its Pathophysiological Consequences
The activation of blood coagulation leads to the formation of thrombin that, in turn, converts soluble plasma fibrinogen into insoluble fibrin clot. In healthy individuals, fibrin is effectively degraded; however, in prothrombotic states, proteolysis of fibrin clots are often delayed or even inhibited, and is associated with altered fibrin structure. We have previously shown that in inflammatory conditions like stroke and diabetes, this fibrin forms dense matted deposits. Although there are several factors that modify fibrin structure and delay fibrinolysis in these conditions, no mechanism is yet known to be responsible f...
Source: Heart, Lung and Circulation - December 10, 2012 Category: Cardiology Authors: E. Pretorius, B. Lipinski Tags: Brief Communications Source Type: research
Anaortic, total-arterial, off-pump coronary artery bypass surgery: Why bother?
Coronary artery bypass grafting (CABG) remains the standard of care for multi-vessel coronary disease. However, the increased rate of peri-operative stroke reported after surgery compared to percutaneous coronary intervention (PCI) remains of concern. Anaortic, total-arterial, off-pump coronary artery bypass (OPCAB) grafting is a technique that offers the main advantages of surgical revascularisation with a rate of stroke that is equivalent to that of PCI. Some recent trials comparing conventional on-pump CABG with OPCAB have questioned the efficacy of the off-pump technique – these are most often performed with manipula...
Source: Heart, Lung and Circulation - October 24, 2012 Category: Cardiology Authors: J.J.B. Edelman, A.G. Sherrah, M.K. Wilson, P.G. Bannon, R.J. Brereton, D.E. Ross, M.P. Vallely Tags: Reviews Source Type: research
Dabigatran for Anticoagulation in Atrial Fibrillation – Early Clinical Experience in a Hospital Population and Comparison to Trial Data
Conclusion: In this population our study demonstrates a discontinuation rate of 10% due to side effects of dabigatran, similar to the rate reported in RE-LY. The majority of patients are satisfied with their treatment and preferred dabigatran to warfarin, mainly due to the reduced requirement for blood testing.
Source: Heart, Lung and Circulation - October 10, 2012 Category: Cardiology Authors: Jonathan Michel, David Mundell, Tau Boga, Alexander Sasse Tags: Original Articles Source Type: research
Double Inter-atrial Septum: A Rare Cause of Cardioembolic Stroke
We describe a case of transient ischaemic attack in a 53 year-old female found to have double inter-atrial septa on transthoracic and transoesophageal echocardiography. The midline inter-atrial chamber enclosed by the two septa was found to be continuous with the left atrium, with stasis in this accessory chamber predisposing to thrombus formation and cardio-embolic events. The case highlights the importance of transoesophageal echocardiography in the investigation of stroke, particularly in younger individuals.
Source: Heart, Lung and Circulation - October 8, 2012 Category: Cardiology Authors: Daniel Robaei, Stefan Buchholz, Michael Feneley Tags: Clinical Spotlights Source Type: research
