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Source: Canadian Journal of Cardiology
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Total 265 results found since Jan 2013.
Transcatheter left atrial appendage closure using intracardiac echocardiographic guidance from the left atrium
Conclusion Initial experience suggests LAA occlusion with the Amplatzer Cardiac PlugTM under ICE guidance from the left atrium is feasible, reproducible and safe.
Source: Canadian Journal of Cardiology - May 18, 2015 Category: Cardiology Source Type: research
Hypertension and sleep apnea
Publication date: Available online 16 May 2015 Source:Canadian Journal of Cardiology Author(s): John S. Floras Obstructive sleep apnea is more prevalent in patients with hypertension than in the general population and many with obstructive sleep apnea also have hypertension. Obstructive sleep apnea increases the risk of hypertension-related morbidities such as stroke, heart failure, and premature death. Are such associations co-incidental or causal and if the latter, what are its implications for clinical practice? Despite compelling epidemiological and mechanistic links between obstructive sleep apnea and hypertension, ...
Source: Canadian Journal of Cardiology - May 16, 2015 Category: Cardiology Source Type: research
The Risk of Ischemic Heart Disease and Stroke Among Immigrant Populations: A Systematic Review
Conclusions The risks of ischemic heart disease and stroke vary widely in immigrant populations in Western Europe. Detailed studies of immigrants to Canada by country of birth and duration of residence should be undertaken to guide future cardiovascular health promotion initiatives. Teaser This review summarizes 17 studies on the risks of ischemic heart disease (IHD) and stroke among immigrants to high-income countries. The results varied by country-of-origin, host country, and duration of residence. Multiple studies of immigrants to Western Europe show that most immigrant groups are at similar or higher risk of developing...
Source: Canadian Journal of Cardiology - May 16, 2015 Category: Cardiology Source Type: research
Oral anticoagulation for stroke prevention in Canadian practice: Stroke Prevention and Rhythm Interventions in Atrial Fibrillation (SPRINT-AF) registry
Conclusions In this contemporary Canadian AF registry, the rate of guideline-concordant OAC use was high. About half of OAC-treated patients received NOAC agents. Patient- and physician-driven preferences such as side effect profile, perceived greater efficacy, and cost were strong determinants of NOAC over warfarin use. Teaser This is a cross-sectional, retrospective analysis of 936 patients with non-valvular atrial fibrillation enrolled from 106 practices in Canada between December 2012 and July 2013. We observed that the rate of guideline-concordant oral anticoagulation use was high (90%), with new direct oral anticoagu...
Source: Canadian Journal of Cardiology - May 2, 2015 Category: Cardiology Source Type: research
Relationship Between Insulin-like Growth Factor Binding Protein-2 and Left Ventricular Stroke Volume in Patients with Aortic Stenosis
Conclusions In this study, we documented that lower IGFBP-2 levels are independently associated with lower SVi, a powerful predictor of worse outcomes in the mild to moderate AS population. Teaser In aortic stenosis (AS) patients, LV remodeling and function vary extensively from one patient to another. Considering the associations between circulating IGFBP-2 and markers of the metabolic syndrome, the aim of the study was to examine the relationship between circulating IGFBP-2 and left ventricle (LV) pump function as measured by stroke volume index in AS patients with preserved LV ejection fraction.
Source: Canadian Journal of Cardiology - April 30, 2015 Category: Cardiology Source Type: research
“When to suspect sleep apnea and what to do about it”
This article provides an overview of the clinical signs and symptoms of sleep apnea, approaches to diagnostic testing and the main therapeutic strategies for both obstructive and central sleep apnea.”
Source: Canadian Journal of Cardiology - April 28, 2015 Category: Cardiology Source Type: research
Effect of aortic annulus size and prosthesis oversizing on the hemodynamics and leaflet bending stress of transcatheter valves: an in vitro study
Conclusions The hemodynamic performance of THV is, in large part, determined by the aortic annulus diameter in which the valve is deployed. Oversizing (up to 20% in area) has no significant effect on valve EOA but is associated with higher leaflet bending stress, which might promote faster structural valve degeneration in the long-term. Teaser Paravalvular regurgitation is still an important complication following transcatheter aortic valve implantation. The use modest prosthesis oversizing (i.e. 5-10%) was suggested to reduce their incidence. This study suggests that oversizing (up to 20 % in area) has no significant effe...
Source: Canadian Journal of Cardiology - April 21, 2015 Category: Cardiology Source Type: research
The case against using hypertension as the only criterion for oral anticoagulation in atrial fibrillation
Publication date: Available online 24 March 2015 Source:Canadian Journal of Cardiology Author(s): Simon W. Rabkin , Gordon Moe According to recent guidelines for atrial fibrillation (AF) management, the presence of hypertension warrants anticoagulation, often involving the use of newer oral anticoagulants (NOACs). To discuss this idea, we posited the case against this proposition. We note that the data on hypertension that formulated the most commonly used (CHADS2) risk algorithm were not clearly defined and there is insufficient data that hypertension in the presence of AF produces a meaningful incremental increase in s...
Source: Canadian Journal of Cardiology - March 25, 2015 Category: Cardiology Source Type: research
Sleep Apnea and Stroke
Publication date: Available online 14 March 2015 Source:Canadian Journal of Cardiology Author(s): Owen D. Lyons , Clodagh M. Ryan Stroke is the second leading cause of death worldwide and often has devastating consequences for affected individuals in terms of chronic disability. Traditional risk factors such as age, male sex, ethnicity, hypertension and atrial fibrillation explain 60-80% of the risk of stroke. Obstructive sleep apnea (OSA) is highly prevalent in the post-stroke population and its emerging role as a potential modifiable risk factor for stroke has been recognised in the most recent American Heart Associati...
Source: Canadian Journal of Cardiology - March 14, 2015 Category: Cardiology Source Type: research
Blood pressure control in Canada: the view from a stroke prevention clinic
Publication date: Available online 11 March 2015 Source:Canadian Journal of Cardiology Author(s): J. David Spence
Source: Canadian Journal of Cardiology - March 11, 2015 Category: Cardiology Source Type: research
Association of Inflammatory and Hemostatic Markers With Stroke and Thromboembolic Events in Atrial Fibrillation: A Systematic Review and Meta-analysis
Conclusions In conclusion, increased circulating PAI-1 and TAT levels were significantly associated with subsequent stroke in patients with AF, and high levels of D-dimer were associated with thromboembolic events in AF. Further epidemiologic studies are needed to accumulate more evidence on the prognostic role of inflammatory and hemostatic markers in AF.
Source: Canadian Journal of Cardiology - March 5, 2015 Category: Cardiology Source Type: research
Troponin Rise in Hospitalized Patients With Nonacute Coronary Syndrome: Retrospective Assessment of Outcomes and Predictors
Conclusions Unlike the published literature, our study includes a variety of both operative and nonoperative clinical settings associated with troponin elevation. We illustrate that although overall mortality is high after type II MI, the majority of mortality is caused by noncardiovascular events.
Source: Canadian Journal of Cardiology - March 5, 2015 Category: Cardiology Source Type: research
The Disconnect between Novel Oral Anticoagulant Eligibility & Provincial Drug Coverage: An Albertan Anticoagulation Clinic Audit
Publication date: Available online 25 February 2015 Source:Canadian Journal of Cardiology Author(s): Sandeep K. Dhillon , M Sean McMurtry , Tammy J. Bungard Canadian practice guidelines for non-valvular atrial fibrillation (NVAF) recommend most patients receive a novel oral anticoagulant (NOAC) in preference to warfarin to prevent stroke, but not all patients have insurance that covers NOACs. The gap between optimal therapy and drug coverage is unknown. We retrospectively assessed eligibility for NOACs in those with NVAF at our single-centre Anticoagulation Clinic and ascertained whether provincial drug coverage would be...
Source: Canadian Journal of Cardiology - February 25, 2015 Category: Cardiology Source Type: research
CHA2DS2-VASC and CHADS2 Scores Predict Adverse Clinical Events in Pacemaker Patients with Sinus Node Dysfunction Independent of Atrial Fibrillation
Conclusion Both CHA2DS2-VASc and CHADS2 scores predict risk of death or stroke in patients with sick sinus syndrome, regardless of AF history. These scores could be risk stratification tools for clinical events that could respond to new therapies, i.e. anticoagulation or other interventions, even in the absence of AF. Teaser Currently, CHA2DS2-VASc and CHADS2 scores are tallied only for patients who have atrial fibrillation (AF). We found that these scores predict death and stroke independent of AF. The scores could be risk stratification tools for clinical events that could respond to new therapies, i.e. anticoagulation o...
Source: Canadian Journal of Cardiology - February 20, 2015 Category: Cardiology Source Type: research
The new Pooled Cohort Equations Risk Calculator
Publication date: Available online 4 February 2015 Source:Canadian Journal of Cardiology Author(s): David Preiss , Søren L. Kristensen In the NCEP ATPIII guidelines published in 2001, estimation of cardiovascular risk was recommended based on the Framingham score for ten year risk of myocardial infarction while the Canadian Cardiovascular Society currently recommends the Framingham total cardiovascular risk score. During development of joint guidelines released in 2013 by the American College of Cardiology (ACC) and American Heart Association (AHA), the decision was taken to develop a new risk score. This resulted in th...
Source: Canadian Journal of Cardiology - February 6, 2015 Category: Cardiology Source Type: research
