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Source: Canadian Journal of Cardiology
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Total 265 results found since Jan 2013.
Routine Glycoprotein IIb/IIIa Inhibitor Therapy in ST-Segment Elevation Myocardial Infarction: A Meta-Analysis
ConclusionsRoutine GPI administration in STEMI resulted in mortality reduction, driven by reductions in recurrent ischemic events – however predominantly in trials pre-prasugrel/ticagrelor. Trials in contemporary STEMI management are needed to confirm these findings.
Source: Canadian Journal of Cardiology - May 8, 2019 Category: Cardiology Source Type: research
Outcomes Among Clopidogrel, Prasugrel, And Ticagrelor In Stemi Patients Undergoing Primary Percutaneous Coronary Intervention From The Total Trial
ConclusionsIn this observational analysis of STEMI patients undergoing PPCI, ticagrelor was associated with improved outcomes compared to clopidogrel and prasugrel. An appropriately powered randomized trial is needed to confirm these findings.
Source: Canadian Journal of Cardiology - May 8, 2019 Category: Cardiology Source Type: research
Blinded Randomized trial of Anticoagulation to prevent Ischemic stroke and Neurocognitive impairment in AF (BRAIN-AF): Methods and design
ConclusionBRAIN-AF will determine whether oral anticoagulation therapy with rivaroxaban compared with standard of care reduces the risk of stroke, TIA or cognitive decline in patients with non-valvular AF and a low risk of stroke.
Source: Canadian Journal of Cardiology - May 8, 2019 Category: Cardiology Source Type: research
Acute Myocardial Infarction in Severe Mental Health Illness: prevalence, clinical outcomes and process of care in United States hospitalizations.
ConclusionSchizophrenia and ‘other non-organic psychoses’ are the only SMI subtypes associated with adverse clinical outcomes after AMI. However, all patients with SMI were less likely to receive invasive management for AMI, with women and schizophrenia diagnosis being the strongest predictors of conservative management. A multidisciplinary approach between psychiatrists and cardiologists could improve outcomes of this high-risk population.
Source: Canadian Journal of Cardiology - May 3, 2019 Category: Cardiology Source Type: research
Statin Use in Primary Prevention: A Simple Trial-Based Approach Compared With Guideline-Recommended Risk Algorithms for Selection of Eligible Patients
ConclusionsThe pragmatic HOPE-3 trial approach identifies in an ethnically diverse primary prevention population individuals at intermediate risk who benefit from statin therapy using simple clinical characteristics without the need for complex, currently used risk assessment tools.RésuméIntroductionLes outils d’évaluation du risque de maladie cardiovasculaire permettent de repérer les patients qui pourraient bénéficier d’un traitement préventif. Nous avons donc comparé les résultats obtenus au moyen de l’algorithme d’évaluation du risque de l’American College of Cardiology/American Heart Association (A...
Source: Canadian Journal of Cardiology - April 27, 2019 Category: Cardiology Source Type: research
Prothrombotic State in Atrial Fibrillation Patients With One Additional Risk Factor of the CHA2DS2-VASc Score (Beyond Sex)
ConclusionsA prothrombotic state (increased thrombin generation, denser fibrin clots, impaired fibrinolysis, and endothelial injury) characterizes patients with AF with 1 additional clinical stroke risk factor (beyond sex), with age 65-74 years being particularly associated with prothrombotic indices.RésuméContexteLa question de savoir si un état prothrombotique survient chez les patients atteints de fibrillation auriculaire (FA) à faible risque d’accident vasculaire cérébral (AVC) n’a pas été élucidée.MéthodologieNous avons étudié 118 patients atteints de FA présentant un score CHA2DS2-VASc (insuffisance...
Source: Canadian Journal of Cardiology - April 27, 2019 Category: Cardiology Source Type: research
Stroke Prevention, Evaluation of Bleeding Risk, and Anticoagulant Treatment Management in Atrial Fibrillation Contemporary International Guidelines
Publication date: May 2019Source: Canadian Journal of Cardiology, Volume 35, Issue 5Author(s): Marco Proietti, Deirdre A. Lane, Giuseppe Boriani, Gregory Y.H. LipAbstractIn recent years the management of atrial fibrillation patients has progressively and substantially changed because of the introduction of new treatments and the availability of new data regarding the epidemiology and clinical management of these patients. In the past 2 years alone, there have been 7 new guidelines or guideline updates that have been published, which have introduced new recommendations and significantly revised previously published ones. Tw...
Source: Canadian Journal of Cardiology - April 27, 2019 Category: Cardiology Source Type: research
Outcome Of Patients Undergoing Transcatheter Implantation Of Aortic Valve With Previous Mitral Valve Prosthesis (OPTIMAL STUDY)
ConclusionsTAVR in patients with a previous mitral prosthesis appears safe and feasible, with good hemodynamic results at 30-day and at longer term follow-up.
Source: Canadian Journal of Cardiology - April 16, 2019 Category: Cardiology Source Type: research
Screening for Atrial Fibrillation using a Mobile, Single-Lead Electrocardiogram in Canadian Primary Care Clinics
ConclusionPreviously undiagnosed AF is common in older individuals attending primary care clinics. The Kardia Mobile ECG device appears to be an effective screening tool for AF with high physician acceptability. More research on the feasibility of such novel technologies is warranted for future consideration of integration in population-based screening programs.
Source: Canadian Journal of Cardiology - April 6, 2019 Category: Cardiology Source Type: research
Peridevice Leak After Left Atrial Appendage Closure: Incidence, Risk Factors, and Clinical Impact
ConclusionsThe PDL rate detected by CCTA after LAAC was high, especially in cases with a low device compression ratio (< 10%), but decreased over time. The incidence of MACE was quantitatively greater with PDL, but the difference was not statistically significant. Larger studies are needed to determine the clinical importance of PDL.RésuméIntroductionPeu d’études ont fait état des taux et des répercussions cliniques des fuites périprothétiques (FPP) après la fermeture de l’appendice auriculaire gauche (AAG) par voie percutanée.MéthodesNous avons inscrit de manière prospective tous les patients consécuti...
Source: Canadian Journal of Cardiology - March 30, 2019 Category: Cardiology Source Type: research
Statin Use in Primary Prevention; a Simple Trial Based Approach Compared to Guideline Recommended Risk Algorithms for Selection of Eligible Patients
ConclusionThe pragmatic HOPE-3 trial approach identifies in an ethnically diverse primary prevention population individuals at intermediate risk who benefit from statin therapy using simple clinical characteristics without the need for complex, currently used risk assessment tools.
Source: Canadian Journal of Cardiology - March 19, 2019 Category: Cardiology Source Type: research
Early complete revascularization in hemodynamically stable patients with ST-segment elevation myocardial infarction and multivessel disease
ConclusionsEarly complete revascularization should be considered in hemodynamically stable patients with STEMI and multivessel disease deemed suitable for percutaneous interventions. FFR-guided complete revascularization may be superior to angiography-guided procedure in reducing need for further interventions.
Source: Canadian Journal of Cardiology - March 19, 2019 Category: Cardiology Source Type: research
Comparison of Readmission and Death Among Patients With Cardiac Disease in Northern vs Southern Ontario
ConclusionsReadmissions were increased in those residing and hospitalized in the North. To reduce readmissions in the North, the quality of postacute transitional care should be examined further.RésuméContexteDes facteurs géographiques peuvent influer sur l’issue de maladies cardiovasculaires au Canada. Les maladies du système circulatoire constituent une raison majeure du taux de mortalité élevé dans le nord de l’Ontario, mais on ne sait pas si les patients hospitalisés pour une maladie cardiovasculaire connaissent des issues différentes par rapport aux personnes vivant dans le sud.MéthodologieNous avons exa...
Source: Canadian Journal of Cardiology - March 1, 2019 Category: Cardiology Source Type: research
Evolution of blood pressure clinical practice guidelines: a personal perspective
Publication date: Available online 27 February 2019Source: Canadian Journal of CardiologyAuthor(s): Paul K. WheltonAbstractPrior to the second half of the 20th century, most clinical decision-making was based on expert opinion. By the 1960s, experience in actuarial and research cohort studies had provided strong evidence that blood pressure was an important risk factor for cardiovascular disease. The landmark 1967 and 1970 Veterans Administration Cooperative Study trials confirmed the value of antihypertensive drug therapy in preventing stroke, myocardial infarction, and heart failure in adults with a high level of diastol...
Source: Canadian Journal of Cardiology - February 27, 2019 Category: Cardiology Source Type: research
Stroke Prevention, Evaluation of Bleeding Risk and Anticoagulant Treatment Management in Atrial Fibrillation Contemporary International Guidelines
Publication date: Available online 21 February 2019Source: Canadian Journal of CardiologyAuthor(s): Marco Proietti, Deirdre A. Lane, Giuseppe Boriani, Gregory Y.H. LipAbstractIn recent years the management of AF patients has progressively and substantially changed due to the introduction of new treatments and the availability of new data regarding the epidemiology and clinical management of these patients. In the last two years alone, there have been seven new guidelines or guideline updates that have been published, introducing new recommendations and significantly revising previously published ones. Two updates for Canad...
Source: Canadian Journal of Cardiology - February 22, 2019 Category: Cardiology Source Type: research
