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Source: Canadian Journal of Cardiology
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Total 265 results found since Jan 2013.
Aortic root enlargement is safe and reduces the incidence of patient-prosthesis mismatch: A Meta-analysis of early and late outcomes
ConclusionsSurgical ARE is a safe adjunct to AVR in selected patients that does not increase early adverse events and results in less patient-prosthesis mismatch. This strategy allows for a larger valve size at the time of implantation – an important consideration for potential future valve-in-valve procedures in the era of TAVR.
Source: Canadian Journal of Cardiology - February 13, 2019 Category: Cardiology Source Type: research
Optimal duration of dual antiplatelet therapy following percutaneous coronary intervention: An umbrella review
ConclusionsExtended DAPT may reduce the risk of MI and stent thrombosis but increase major bleeding and death. Whether the effects of extended DAPT are consistent across patient subgroups is unclear, and future SRs should address this knowledge gap. PROSPERO: CRD42016047735.
Source: Canadian Journal of Cardiology - February 6, 2019 Category: Cardiology Source Type: research
Pulmonary artery elastic properties after balloon pulmonary angioplasty in patients with inoperable chronic thromboembolic pulmonary hypertension.
ConclusionsBPA improved total CPa in proportion to a decrease in PVR despite no improvement in local elastic properties of the treated PA segments.
Source: Canadian Journal of Cardiology - February 2, 2019 Category: Cardiology Source Type: research
Importance of risk reassessment in patients with atrial fibrillation in guidelines: Assessing risk as a dynamic process
Publication date: Available online 2 February 2019Source: Canadian Journal of CardiologyAuthor(s): Ting-Yung Chang, Gregory Y.H. Lip, Shih-Ann Chen, Tze-Fan ChaoAbstractThe appropriate use of oral anticoagulants (OACs) for stroke prevention in atrial fibrillation (AF) relies on the convenient and accurate stroke risk prediction scheme, namely the CHA2DS2-VASc score. Since AF patients would become older and accumulate more comorbidities, their risk (for example, as reflected by the CHA2DS2-VASc scores) are not static and could increase over time. The available data demonstrated that follow-up and delta CHA2DS2-VASc scores p...
Source: Canadian Journal of Cardiology - February 2, 2019 Category: Cardiology Source Type: research
Prothrombotic state in atrial fibrillation patients with 1 additional risk factor of the CHA2DS2-VASc score (beyond sex)
ConclusionsA prothrombotic state (increased thrombin generation, denser fibrin clots, impaired fibrinolysis, and endothelial injury) characterizes AF patients with one additional clinical stroke risk factor (beyond sex), with age 65-74 years being particularly associated with a prothrombotic indices.
Source: Canadian Journal of Cardiology - January 30, 2019 Category: Cardiology Source Type: research
Peri-Device Leak after Left Atrial Appendage Closure: Incidence, Risk Factors and Clinical Impact
ConclusionsPDL rate detected by CCTA after LAAC is high, especially in cases with low device compression ratio (<10%), but decreased over time. The incidence of MACE was quantitatively greater with PDL, but the difference was not statistically significant. Larger studies are needed to determine the clinical importance of PDL.
Source: Canadian Journal of Cardiology - December 21, 2018 Category: Cardiology Source Type: research
Modality selection for the revascularization of left main disease
Publication date: Available online 15 December 2018Source: Canadian Journal of CardiologyAuthor(s): Derrick Y. Tam, Faisal Bakaeen, Dmitriy N. Feldman, Philippe Kolh, Gaetano Antonio Lanza, Marc Ruel, Raffaele Piccolo, Stephen E. Fremes, Mario FL. GaudinoAbstractThe management of severe left main (LM) disease remains controversial and continues to evolve as new evidence emerges. Patient selection for CABG or PCI relies on both predicting mortality with CABG from clinical characteristics using the Society of Thoracic Surgeons risk score and anatomical complexity using the SYNTAX score. LM stenting techniques continue to evo...
Source: Canadian Journal of Cardiology - December 15, 2018 Category: Cardiology Source Type: research
Impact of Discharge Location After Transcatheter Aortic Valve Replacement On 1-Year Outcomes In Women: Results From The WIN-TAVI Registry
ConclusionsIn women undergoing contemporary TAVR, discharge disposition significantly affects 1-year risk of outcomes even after adjustment for recorded baseline differences. This might suggest the necessity of considering additional factors beyond comorbidities in the TAVR decision-making process.
Source: Canadian Journal of Cardiology - December 12, 2018 Category: Cardiology Source Type: research
Stroke in HIV
Publication date: Available online 6 December 2018Source: Canadian Journal of CardiologyAuthor(s): Milana Bogorodskaya, Felicia C. Chow, Virginia A. TriantAbstractStroke is a heterogeneous disease in persons living with HIV (PLWH). HIV is thought to increase the risk of stroke through both HIV-related and traditional stroke risk factors, which vary with respect to the patient’s age and clinical characteristics. Numerous studies show that detectable viremia and immunosuppression increase the risk of stroke across all ages while traditional risk factors are more common in the aging HIV population. As PLWH age and acquire t...
Source: Canadian Journal of Cardiology - December 6, 2018 Category: Cardiology Source Type: research
Association Between Patient and Physician Sex and Physician-Estimated Stroke and Bleeding Risks in Atrial Fibrillation
ConclusionsOur study is the first to examine the association between patient and physician sex influences and stroke and bleeding risk estimation in AF. While there were differences in agreement between physician estimated stroke risk and calculated CHADS2 scores, these differences were small and unlikely to impact clinical practice; further, despite any perceived differences in the accuracy of risk assessment by sex, most patients received anticoagulation.
Source: Canadian Journal of Cardiology - December 4, 2018 Category: Cardiology Source Type: research
Antithrombotic Therapy for Atrial Fibrillation and Coronary Disease Demystified
Publication date: November 2018Source: Canadian Journal of Cardiology, Volume 34, Issue 11Author(s): Jason G. Andrade, Marc W. Deyell, Graham C. Wong, Laurent MacleAbstractAtrial fibrillation (AF) is a progressive chronic disease characterized by exacerbations and periods of remission. It is estimated that up to 20% to 30% of those with AF also have coronary artery disease (CAD), and 5% to 15% will require percutaneous coronary intervention (PCI). In patients with concomitant AF and CAD, management remains challenging and requires a careful and balanced assessment of the risk of bleeding against the anticipated impact on i...
Source: Canadian Journal of Cardiology - November 6, 2018 Category: Cardiology Source Type: research
The Guideline-Policy Gap in Direct-Acting Oral Anticoagulants Usage in Atrial Fibrillation: Evidence, Practice, and Public Policy Considerations
Publication date: November 2018Source: Canadian Journal of Cardiology, Volume 34, Issue 11Author(s): Douglas Wan, Jeff S. Healey, Chris S. SimpsonAbstractAtrial fibrillation has a high disease burden—both in prevalence and associated consequences. Despite anticoagulation being an effective treatment in atrial fibrillation, stroke prevention is slow to reflect evidence-based practice. Real-world data reveal a substantial portion of patients who would benefit from anticoagulation, yet do not receive it adequately or at all. A large part of this suboptimal treatment is due to the underutilization of direct oral anticoagulan...
Source: Canadian Journal of Cardiology - November 6, 2018 Category: Cardiology Source Type: research
New Insights into the Use of Cardiac Magnetic Resonance Imaging to Guide Decision Making in Atrial Fibrillation Management
Publication date: Available online 12 July 2018Source: Canadian Journal of CardiologyAuthor(s): Tarek Zghaib, Saman NazarianAbstractRecent advances in cardiac magnetic resonance (CMR) imaging acquisition techniques have enabled the visualization of thin atrial myocardium with high temporal and spatial resolution and have the potential to shift atrial fibrillation (AF) management paradigms. Late gadolinium-enhancement (LGE)-CMR can noninvasively identify atrial arrhythmogenic scar substrates and has been shown to spatially correlate with low-voltage areas. Immediately after ablation, a combination of native T1-weighted, LGE...
Source: Canadian Journal of Cardiology - October 6, 2018 Category: Cardiology Source Type: research
Patterns of incidence rates of cardiac complications in patients with congenital heart disease
ConclusionsCardiac complications are frequent in congenital heart disease. Apart from perioperative stroke and complete heart block, incidence rates are low in childhood but the incidence increases during adult life. These data underscore the need of life-long follow up and may help for better allocation of resources maintaining follow-up.
Source: Canadian Journal of Cardiology - October 4, 2018 Category: Cardiology Source Type: research
The multiple causes of stroke in atrial fibrillation: Thinking broadly
Publication date: Available online 30 August 2018Source: Canadian Journal of CardiologyAuthor(s): Atlantic D’Souza, Kenneth S. Butcher, Brian H. BuckAbstract:Atrial Fibrillation (AF) is numerically the most important risk factor for stroke. It is well established that patients with AF have a five-fold increased risk of stroke relative to those without, and that anticoagulation reduces the risk of stroke by approximately two-thirds. Definitively attributing the mechanism of an individual stroke to AF is much more problematic, however. In fact, there is no way to reliably establish the etiology of any ischemic infarction. ...
Source: Canadian Journal of Cardiology - August 31, 2018 Category: Cardiology Source Type: research
