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Source: Canadian Journal of Cardiology
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Total 265 results found since Jan 2013.
Invasive or Conservative Approach in Elderly Patients with Non-ST-segment Elevation Myocardial Infarction: Systematic Review and Meta-Analysis
Conclusion The “overall” benefit with “invasive” strategy comes from the data of observational studies that are prone to selection bias. We believe that there is a need for a large randomised study in the elderly patients regarding management of NSTEMI. Teaser Trials comparing invasive with conservation treatment for elderly patients presenting with NSTEMI are limited resulting in considerable variation in the management of such patients. In the current systematic review, we tried to consolidate the current evidence on these 2 modes of treatment. There was a reduction in mortality with the invasive approach. Howeve...
Source: Canadian Journal of Cardiology - December 6, 2017 Category: Cardiology Source Type: research
Mechanisms, Clinical Significance, and Prevention of Cognitive Impairment in Patients With Atrial Fibrillation
Publication date: December 2017 Source:Canadian Journal of Cardiology, Volume 33, Issue 12 Author(s): Lena Rivard, Paul Khairy Atrial fibrillation (AF) and dementia are major health issues, with growing evidence suggesting a consistent association between AF and all forms of dementia. Although dementia and AF share several risk factors, the association appears to be independent of a history of clinical stroke and other comorbidities such as hypertension, heart failure, and diabetes. Proposed mechanisms linking AF to cognitive decline include altered hemodynamics resulting in cerebral hypoperfusion, inflammation, genetic f...
Source: Canadian Journal of Cardiology - December 3, 2017 Category: Cardiology Source Type: research
Antiplatelet Effect of Different Loading Doses of Ticagrelor in Patients With Non –ST-Elevation Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention: The APELOT Trial
Conclusions Doubling the ticagrelor LD achieved faster onset and greater platelet inhibition without an increase in adverse events in patients with NSTE-ACS undergoing PCI.
Source: Canadian Journal of Cardiology - December 3, 2017 Category: Cardiology Source Type: research
The Relationship Between Cardiologist Care and Clinical Outcomes in Patients With New-Onset Atrial Fibrillation
Conclusions Cardiologist care was associated with a reduction in death in patients with new-onset AF. Further study to obtain a greater understanding of the processes of care associated with the observed survival improvement is warranted.
Source: Canadian Journal of Cardiology - December 3, 2017 Category: Cardiology Source Type: research
Blood Pressure Lowering Targets in Patients with Diabetes Mellitus
Publication date: Available online 3 November 2017 Source:Canadian Journal of Cardiology Author(s): Alexander A. Leung, Raj S. Padwal Diabetes is a highly prevalent medical condition that commonly coexists with hypertension. The presence of diabetes and hypertension significantly increases the risk of adverse cardiovascular events. Although compelling evidence exists from randomized controlled trials demonstrating that blood pressure reduction effectively prevents cardiovascular complications, optimal blood pressure targets remain uncertain and continue to be the subject of ongoing controversy. Until recently, most major ...
Source: Canadian Journal of Cardiology - November 4, 2017 Category: Cardiology Source Type: research
Mechanisms, Clinical Significance and Prevention of Cognitive Impairment in Atrial Fibrillation
Publication date: Available online 6 October 2017 Source:Canadian Journal of Cardiology Author(s): Lena Rivard, Paul Khairy Atrial fibrillation (AF) and dementia are major health issues, with growing evidence suggesting a consistent association between AF and all forms of dementia. Although dementia and AF share several risk factors, the association appears to be independent of a history of clinical stroke and other comorbidities such as hypertension, heart failure, and diabetes. Proposed mechanisms linking AF to cognitive decline include altered hemodynamics resulting in cerebral hypoperfusion, inflammation, genetic fact...
Source: Canadian Journal of Cardiology - October 7, 2017 Category: Cardiology Source Type: research
Does dual-antiplatelet therapy decrease the risk of stroke following coronary artery bypass grafting?
Publication date: October 2017 Source:Canadian Journal of Cardiology, Volume 33, Issue 10, Supplement Author(s): J. Higgins, J. Bashir, J. Abel, P. Daniele, M. Lee, K. Humphries
Source: Canadian Journal of Cardiology - September 22, 2017 Category: Cardiology Source Type: research
Chads2 score associated with atrial fibrillation but not predictive of stroke in adults with congenital heart disease
Publication date: October 2017 Source:Canadian Journal of Cardiology, Volume 33, Issue 10, Supplement Author(s): C. Tsui, D. Wan, J. Grewal, A. Barlow, M. Kiess, A. Krahn, D. Human, S. Chakrabarti, J. Sathananthan
Source: Canadian Journal of Cardiology - September 22, 2017 Category: Cardiology Source Type: research
Antiplatelet Effect of Different Loading Doses of Ticagrelor in Non-ST-Elevation Acute Coronary Syndrome Patients Undergoing PCI: The APELOT Trial
Conclusions Doubling the ticagrelor loading dose achieved faster onset and greater platelet inhibition without an increase in adverse events in patients with NSTE-ACS undergoing PCI.
Source: Canadian Journal of Cardiology - September 13, 2017 Category: Cardiology Source Type: research
Transcatheter vs Surgical Aortic Valve Replacement for Aortic Stenosis in Low-Intermediate Risk Patients: A Meta-analysis
Conclusions Although there was no difference in 30-day and late mortality, the rate of complications differed between TAVR and SAVR in the low-intermediate surgical risk population.
Source: Canadian Journal of Cardiology - August 25, 2017 Category: Cardiology Source Type: research
Contemporary Atrial Fibrillation Management: A Comparison of the Current AHA/ACC/HRS, CCS, and ESC Guidelines
Publication date: August 2017 Source:Canadian Journal of Cardiology, Volume 33, Issue 8 Author(s): Jason G. Andrade, Laurent Macle, Stanley Nattel, Atul Verma, John Cairns In this article we compare and contrast the current recommendations, and highlight the important differences, in the American College of Cardiology/American Heart Association/Heart Rhythm Society, European Society of Cardiology, and Canadian Cardiovascular Society atrial fibrillation (AF) guidelines. Although many of the recommendations of the various societies are similar, there are important differences in the methodologies underlying their developmen...
Source: Canadian Journal of Cardiology - July 26, 2017 Category: Cardiology Source Type: research
Transcatheter Versus Surgical Aortic Valve Replacement for Aortic Stenosis in Low-Intermediate Risk Patients: A Meta-Analysis
Conclusions While there was no difference in 30-day and late mortality, the rate of complications differed between TAVR and SAVR in the low-intermediate surgical risk population. Teaser In this meta-analysis, there was no difference in 30-day and median 1.5-year mortality outcomes between TAVR and SAVR. However, there was a higher incidence of aortic insufficiency, vascular complications and permanent pacemaker implantation after TAVR compared to SAVR and a higher incidence of atrial fibrillation, acute kidney injury, major bleeding and cardiogenic shock after SAVR compared to TAVR.
Source: Canadian Journal of Cardiology - June 16, 2017 Category: Cardiology Source Type: research
Contemporary Atrial Fibrillation Management – A comparison of the current AHA/ACC/HRS, CCS, and ESC guidelines
This article compares and contrasts the current recommendations, and highlights the important differences, in the American College of Cardiology (ACC)/American Heart Association (AHA)/Heart Rhythm Society (HRS), European Society of Cardiology (ESC), and Canadian Cardiovascular Society (CCS) atrial fibrillation (AF) guidelines. Although many of the recommendations of the various societies are similar, there are important differences in the methodologies underlying their development and the specific content. Specifically, key differences can be observed in: 1) the definition of non-valvular AF, which subsequently impacts ant...
Source: Canadian Journal of Cardiology - June 10, 2017 Category: Cardiology Source Type: research
Rationale, Design and Baseline Characteristics of Participants in the Cardiovascular OutcoMes for People Using Anticoagulation StrategieS (COMPASS) Trial
Conclusion COMPASS will provide information on the efficacy and safety of rivaroxaban, alone or in combination with aspirin, in the long-term management of patients with stable CAD or PAD, and on the efficacy and safety of pantoprazole in preventing upper GI complications in patients receiving antithrombotic therapy. Teaser COMPASS is a global randomized controlled trial comparing rivaroxaban 2.5mg twice-daily plus aspirin 100mg once-daily, rivaroxaban 5mg twice-daily, and aspirin 100mg once-daily for prevention of myocardial infarction, stroke, or cardiovascular death in patients with stable coronary or peripheral artery ...
Source: Canadian Journal of Cardiology - June 8, 2017 Category: Cardiology Source Type: research
Atrial Fibrillation and End Stage Renal Failure in Patients Receiving Dialysis: Balancing the Risks and Benefits of Stroke Prevention
Publication date: June 2017 Source:Canadian Journal of Cardiology, Volume 33, Issue 6 Author(s): Christos Voukalis, Gregory Y.H. Lip
Source: Canadian Journal of Cardiology - May 24, 2017 Category: Cardiology Source Type: research
