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Source: Canadian Journal of Cardiology
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Total 265 results found since Jan 2013.
Key Questions Relating to Left Ventricular Noncompaction Cardiomyopathy: Is the Emperor Still Wearing Any Clothes?
Publication date: June 2017 Source:Canadian Journal of Cardiology, Volume 33, Issue 6 Author(s): Robert H. Anderson, Bjarke Jensen, Timothy J. Mohun, Steffen E. Petersen, Nay Aung, Filip Zemrak, R. Nils Planken, David H. MacIver The evidence is increasing that left ventricular noncompaction cardiomyopathy as it is currently defined does not represent a failure of compaction of pre-existing trabecular myocardium found during embryonic development to form the compact component of the ventricular walls. Neither is there evidence of which we are aware to favour the notion that the entity is a return to a phenotype seen in col...
Source: Canadian Journal of Cardiology - May 24, 2017 Category: Cardiology Source Type: research
Hypertension Canada's 2017 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults
Publication date: May 2017 Source:Canadian Journal of Cardiology, Volume 33, Issue 5 Author(s): Alexander A. Leung, Stella S. Daskalopoulou, Kaberi Dasgupta, Kerry McBrien, Sonia Butalia, Kelly B. Zarnke, Kara Nerenberg, Kevin C. Harris, Meranda Nakhla, Lyne Cloutier, Mark Gelfer, Maxime Lamarre-Cliche, Alain Milot, Peter Bolli, Guy Tremblay, Donna McLean, Sheldon W. Tobe, Marcel Ruzicka, Kevin D. Burns, Michel Vallée, G.V. Ramesh Prasad, Steven E. Gryn, Ross D. Feldman, Peter Selby, Andrew Pipe, Ernesto L. Schiffrin, Philip A. McFarlane, Paul Oh, Robert A. Hegele, Milan Khara, Thomas W. Wilson, S. Brian Penner, Ellen Bu...
Source: Canadian Journal of Cardiology - April 25, 2017 Category: Cardiology Source Type: research
Interpatient Variation in Rivaroxaban and Apixaban Plasma Concentrations in Routine Care
Conclusions In this routine care setting, rivaroxaban and apixaban plasma concentrations tended to be more variable than those observed in clinical trials. Identification of additional clinical and molecular determinants that more fully predict patients at risk for excessively high or low DOAC concentrations may enable a more precise DOAC dosing regimen for the individual patient. Teaser Direct-acting oral anticoagulants (DOACs) represent an important new class of medications which are widely prescribed as an alternative to warfarin therapy, however there is a lack of data relating to observed DOAC plasma concentrations wi...
Source: Canadian Journal of Cardiology - April 24, 2017 Category: Cardiology Source Type: research
Hypertension Canada ’s 2017 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults
Publication date: Available online 10 March 2017 Source:Canadian Journal of Cardiology Author(s): Alexander A. Leung, Stella S. Daskalopoulou, Kaberi Dasgupta, Kerry McBrien, Sonia Butalia, Kelly B. Zarnke, Kara Nerenberg, Kevin C. Harris, Meranda Nakhla, Lyne Cloutier, Mark Gelfer, Maxime Lamarre-Cliche, Alain Milot, Peter Bolli, Guy Tremblay, Donna McLean, Sheldon W. Tobe, Marcel Ruzicka, Kevin D. Burns, Michel Vallée, G. V. Ramesh Prasad, Steven E. Gryn, Ross D. Feldman, Peter Selby, Andrew Pipe CM, Ernesto L. Schiffrin, Philip A. McFarlane, Paul Oh, Robert A. Hegele, Milan Khara, Thomas W. Wilson, S. Brian Penner, El...
Source: Canadian Journal of Cardiology - March 9, 2017 Category: Cardiology Source Type: research
Atrial Fibrillation and end-stage renal failure patients on dialysis: balancing the risks and benefits of stroke prevention
Publication date: Available online 28 February 2017 Source:Canadian Journal of Cardiology Author(s): Christos Voukalis, Gregory YH. Lip
Source: Canadian Journal of Cardiology - February 27, 2017 Category: Cardiology Source Type: research
MicroRNAs in the Pathobiology and Therapy of Atherosclerosis
Publication date: March 2017 Source:Canadian Journal of Cardiology, Volume 33, Issue 3 Author(s): Benoit Laffont, Katey J. Rayner MicroRNAs are short noncoding RNAs, expressed in humans and involved in sequence-specific post-transcriptional regulation of gene expression. They have emerged as key players in a wide array of biological processes, and changes in their expression and/or function have been associated with plethora of human diseases. Atherosclerosis and its related clinical complications, such as myocardial infarction or stroke, represent the leading cause of death in the Western world. Accumulating experimental...
Source: Canadian Journal of Cardiology - February 21, 2017 Category: Cardiology Source Type: research
Three-Dimensional and Conventional Carotid Ultrasound for Assessment of Carotid Plaque in a Stroke Patient: A Simple Way to Validate Findings
Publication date: March 2017 Source:Canadian Journal of Cardiology, Volume 33, Issue 3 Author(s): Hayrapet Kalashyan, Maher Saqqur, Harald Becher, Cian O'Kelly, Helen Romanchuk, Khurshid Khan, Thomas Jeerakathil, Andrew Wassef, Ashfaq Shuaib Single-sweep automated 3-D ultrasound is a new imaging modality for the assessment of carotid plaque. Its most important application is the measurement of the plaque volume. To our knowledge, to date there is not a widely accepted “gold standard” to validate 3-D plaque volume measurement. We compared the findings of 2-dimensional and 3-D carotid ultrasound imaging with those of po...
Source: Canadian Journal of Cardiology - February 21, 2017 Category: Cardiology Source Type: research
Warfarin and the risk of stroke and bleeding in patients with atrial fibrillation receiving dialysis: A systematic review and meta-analysis
Conclusion Observational studies suggest that warfarin was not associated with a clear benefit or harm among patients who have atrial fibrillation and are receiving dialysis. These estimates were limited by study heterogeneity including the inability to account for a number of important confounders such as the time in the therapeutic range. Given the high prevalence of atrial fibrillation, stroke, and bleeding complications in this population, well-designed clinical trials of warfarin and other anti-coagulants are urgently needed. Teaser Patients with atrial fibrillation receiving maintenance dialysis are at a high risk of...
Source: Canadian Journal of Cardiology - February 20, 2017 Category: Cardiology Source Type: research
Key Questions relating to left ventricular noncompaction cardiomyopathy - Is the Emperor still wearing any clothes?
Publication date: Available online 1 February 2017 Source:Canadian Journal of Cardiology Author(s): Robert H. Anderson, Bjarke Jensen, Timothy J. Mohun, Steffen E. Petersen, Nay Aung, Filip Zemrak, R Nils Planken, David H. MacIver The evidence is increasing that left ventricular noncompaction cardiomyopathy, as it is currently defined, does not represent failure of compaction of pre-existing trabecular myocardium found during embryonic development so as to form the compact component of the ventricular walls. Nor is there evidence, of which we are aware, to favour the notion that the entity is a return to a phenotype as se...
Source: Canadian Journal of Cardiology - January 31, 2017 Category: Cardiology Source Type: research
Efficacy of Calcium Channel Blockers on Major Cardiovascular Outcomes for the Treatment of Hypertension in Asian Populations: A Meta Analysis
Conclusion There is no evidence that dihydropyridine calcium channel blockers are superior to other antihypertensive agents in Asian populations for the treatment of hypertension. Teaser Whether calcium channel blockers exert a greater effect on cardiovascular risk reduction in Asian populations than other antihypertensive agents is unknown. We conducted a meta-analysis of hypertension trials of dihydropyridine calcium channel blockers in Asian populations to clarify this association. We noted no evidence that dihydropyridine calcium channel blockers are superior to other antihypertensive agents in Asian populations at red...
Source: Canadian Journal of Cardiology - January 20, 2017 Category: Cardiology Source Type: research
Rational medical therapy is the key to effective cardiovascular disease prevention
Publication date: Available online 19 January 2017 Source:Canadian Journal of Cardiology Author(s): J. David Spence In an era in which personalized medicine based on genotyping is being proposed, it is timely to recognize that existing therapies could be markedly improved if based on available phenotyping. Blood pressure control, which is poor on a worldwide basis, is a major opportunity to reduce cardiovascular risk. There are many genetic variants that have a small effect on blood pressure, but specific therapies are not available for most of them. Individualized therapy for hypertension using plasma renin and aldostero...
Source: Canadian Journal of Cardiology - January 18, 2017 Category: Cardiology Source Type: research
MicroRNAs in the pathobiology of atherosclerosis
Publication date: Available online 5 January 2017 Source:Canadian Journal of Cardiology Author(s): Benoit Laffont, Katey J. Rayner MicroRNAs are short non-coding RNAs, expressed in humans and involved in sequence-specific post-transcriptional regulation of gene expression. They have emerged as key players in a wide array of biological processes, and changes in their expression and/or function have been associated with plethora of human diseases. Atherosclerosis and its related clinical complications, such as myocardial infarction or stroke, represent the leading cause of death in the western world. Accumulating experiment...
Source: Canadian Journal of Cardiology - January 5, 2017 Category: Cardiology Source Type: research
The Emerging Epidemic of Cardiovascular Risk Factors and Atherosclerotic Disease in Developing Countries
Publication date: Available online 24 December 2016 Source:Canadian Journal of Cardiology Author(s): Koon K. Teo, Hisham Dokainish Cardiovascular disease (CVD) and its risk factors, major health burdens in high income countries, are a growing problem in developing or lower income countries, where the vast majority of CVD now occurs. Two case control studies, INTERHEART and INTERSTROKE, which included a majority of patients from developing countries, were seminal in identifying common risk factors explaining the vast majority of risk of acute myocardial infarction and stroke, respectively. The population-based PURE study w...
Source: Canadian Journal of Cardiology - December 23, 2016 Category: Cardiology Source Type: research
At What Age Does Stroke Risk Increase in Patients With Atrial Fibrillation? Does It Depend on Where You Live?
Publication date: December 2016 Source:Canadian Journal of Cardiology, Volume 32, Issue 12 Author(s): Jeff S. Healey
Source: Canadian Journal of Cardiology - November 21, 2016 Category: Cardiology Source Type: research
Lack of Association Between Extracranial Carotid and Vertebral Artery Disease and Stroke After Transcatheter Aortic Valve Replacement
Conclusions The presence or absence of carotid or vertebral artery stenosis was not significantly related to the occurrence of stroke after TAVR. Routine screening for carotid and vertebral artery disease before TAVR does not appear justified.
Source: Canadian Journal of Cardiology - November 21, 2016 Category: Cardiology Source Type: research
