Interpatient Variation in Rivaroxaban and Apixaban Plasma Concentrations in Routine Care

Conclusions In this routine care setting, rivaroxaban and apixaban plasma concentrations tended to be more variable than those observed in clinical trials. Identification of additional clinical and molecular determinants that more fully predict patients at risk for excessively high or low DOAC concentrations may enable a more precise DOAC dosing regimen for the individual patient. Teaser Direct-acting oral anticoagulants (DOACs) represent an important new class of medications which are widely prescribed as an alternative to warfarin therapy, however there is a lack of data relating to observed DOAC plasma concentrations within the post-market clinical setting. In this study we examine the extent of interpatient variation in the circulating DOAC plasma concentrations of 243 atrial fibrillation patients prescribed rivaroxaban and apixaban in a routine clinical care setting.
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research