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Uncovering the Rosetta Stone: Report from the First Annual Conference on Key Elements in Translating Stroke Therapeutics from Pre-Clinical to Clinical
AbstractThe first annual Stroke Translational Research Advancement Workshop (STRAW), entitled “Uncovering the Rosetta Stone: Key Elements in Translating Stroke Therapeutics from Pre-Clinical to Clinical” was held at the University of Kentucky on October 4–5, 2017. This workshop was organized by the Center for Advanced Translational Stroke Science. The workshop consisted of 2 days of a ctivities. These included three presentations establishing the areas of research in stroke therapeutics, discussing the routes for translation from bench to bedside, and identifying successes and failures in the field. On day 2, grant ...
Source: Translational Stroke Research - April 10, 2018 Category: Neurology Source Type: research

Safety of tPA + Transcranial Emission of Low-Energy Lasers for Acute Stroke Recovery - Results (P4.219)
Conclusion: Transcranial Laser in this small exploratory study was well tolerated in combination with IV tPA. Larger studies are needed to explore if the combination of LASER therapy plus tPA is safe and shows better outcome than IV tPA alone.Study supported by NIH Grant P50 NS044148Clinical Trial Registry: NCT01220739Disclosure: Dr. Hemmen has nothing to disclose. Dr. Raman has nothing to disclose. Dr. Sen has received personal compensation for activities with Genentech Inc., Sanofi Aventis Pharmaceutical Inc., Bristol-Myers Squibb Co., and Boehringer Ingelheim Pharmaceuticals Inc. Dr. Sen has received research support fr...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Hemmen, T., Raman, R., Sen, S., Geraghty, M., Rapp, K., Richeri, S., Meyer, B., Zivin, J., Fanale, C. Tags: Cerebrovascular Disease and Interventional Neurology: Acute Stroke Thrombolysis Source Type: research

Alpha 1-Antitrypsin Therapy Mitigated Ischemic Stroke Damage in Rats
Our objective is to develop a new therapy for the treatment of stroke. Currently, the only effective therapy for acute ischemic stroke is the thrombolytic agent recombinant tissue plasminogen activator. α1-Antitrypsin (AAT), a serine proteinase inhibitor with potent anti-inflammatory, anti-apoptotic, antimicrobial, and cytoprotective activities, could be beneficial in stroke. The goal of this study is to test whether AAT can improve ischemic stroke outcome in an established rat model. Middle cerebral artery occlusion was induced in male rats via intracranial (i.c.) microinjection of endothelin-1. Five to 10 minutes after...
Source: Journal of Stroke and Cerebrovascular Diseases - March 3, 2014 Category: Neurology Authors: Huong L. Moldthan, Aaron C. Hirko, Jeffrey S. Thinschmidt, Maria B. Grant, Zhimin Li, Joanna Peris, Yuanqing Lu, Ahmed S. Elshikha, Michael A. King, Jeffrey A. Hughes, Sihong Song Tags: Original Articles Source Type: research

Preliminary Assessment of the Motor Activity Log-28 in Patients with Chronic Stroke (P5.174)
CONCLUSIONS: MAL-28 was an acceptable self-report measure of baseline ability for less impaired stroke participants. Quality of arm use in a non-clinical setting detected by the MAL-28 was sensitive to qualitative changes assessed by clinical evaluation. Study Supported by: University of Maryland School of Medicine NIA Short-Term Training Program on Aging Grant T35AG036679;VA Department of Research & Development Merit Grant B6935R. Disclosure: Dr. Simpson has nothing to disclose. Dr. Conroy has nothing to disclose. Dr. Bever has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Simpson, A., Conroy, S., Bever, C. Tags: Neuro-rehabilitation: Stroke Source Type: research

"Worth the Walk:" A Randomized Controlled Trial of a Walking Intervention to Decrease Stroke Risk Among Minority Seniors (S51.002)
Conclusions:We successfully implemented a community-partnered, culturally-tailored, sustainable program to increase walking in minority seniors. Preliminary data analysis suggests improvement in non-sustained increases in steps/day. Next steps include more extensive data analyses, including stakeholder interviews, and examination of participant-level and organizational features associated with more successful study outcomes and program implementation.Study Supported by: - University of California, Los Angeles (UCLA) and Charles Drew University (CDU), Resource Centers for Minority Aging Research Center for Health Improvemen...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Song, S., Araiza, D., Reyes, C., Willis, P., Choi, S., Kotick, J., Jimenez, E., Ma, S., Trejo, L., Carrillo, C., Sarkisian, C. Tags: Cerebrovascular Disease and Interventional Neurology: Stroke Prevention and Translation Source Type: research

Detection of Paroxysmal Atrial Fibrillation in Very Young Cryptogenic Ischemic Stroke Patients under 40 Years: A Three Week ECG-Holter Monitoring Study (P7.121)
CONCLUSIONS: PAF was detected in 5 [percnt] of very young CIS patients < 40 years. Long-term ECG-Holter monitoring seems to be beneficial in the detection of PAF also in very young stroke population. Study supported by: IGA MH CR grants NT11046-6/2010, NT14288-3/2013 and by RVO FNOL 00098892.Disclosure: Dr. Kral has nothing to disclose. Dr. Sanak has received personal compensation for activities with Boehringer Ingelheim Pharmaceuticals, Inc. as a scientific advisory board member and/or speaker. Dr. Hutyra has nothing to disclose. Dr. Fedorco has nothing to disclose. Dr. Skoloudik has nothing to disclose. Dr. Kanovsky h...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Kral, M., Sanak, D., Hutyra, M., Fedorco, M., Skoloudik, D., Kanovsky, P. Tags: Cerebrovascular Disease and Interventional Neurology: Stroke in Young Source Type: research

Neurogenic cardiac outcome in patients after acute ischemic stroke: The brain and heart connection
This study aims to identify the association between cardiac outcomes and middle cerebral artery (MCA) ischemic stroke, with or without insular cortex involvement, as well as the impact of new-onset atrial fibrillation (AF) after AIS on recurrent stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - October 28, 2022 Category: Neurology Authors: Jiangyong Min, Grant Young, Abdullah Umar, Andrew Kampfschulte, Asad Ahrar, Malgorzata Miller, Nadeem Khan, Nabil Wees, Nagib Chalfoun, Muhib Khan Tags: Review Article Source Type: research

Common Caregiver Issues and Nursing Interventions After a Stroke State-of-the-Science Nursing Review
Source: Stroke - July 28, 2014 Category: Neurology Authors: Grant, J. S., Hunt, C. W., Steadman, L. Tags: Behavioral/psychosocial - stroke, Behavioral Changes and Stroke State-of-the-Science Nursing Review Source Type: research

Computational Image Analysis of Nonenhanced Computed Tomography for Acute Ischaemic Stroke: A Systematic Review
Noncontrast enhanced computed tomography (NCCT) remains the most common method for brain imaging patients who present acutely with ischaemic stroke. Computational methods may improve NCCT analysis in this context. We systematically reviewed current research.
Source: Journal of Stroke and Cerebrovascular Diseases - March 2, 2020 Category: Neurology Authors: Paul Mikhail, Michael Gia Duy Le, Grant Mair Source Type: research

Cell-Based Therapies for Stroke: Promising Solution or Dead End? Mesenchymal Stem Cells and Comorbidities in Preclinical Stroke Research
Conclusion The high prevalence of comorbidities in patients with stroke indicates the need for therapies in preclinical studies that take into account these comorbidities in order to avoid failures in translation to the patient. Preclinical studies are beginning to evaluate the efficacy of MSC treatment in stroke associated with comorbidities, especially hypertension, for ischemic and hemorrhagic stroke. Regarding aging and diabetes, only ischemic stroke studies have been performed. For the moment, few studies have been performed and contradictory results are being reported. These contradictory results may be due to the u...
Source: Frontiers in Neurology - April 8, 2019 Category: Neurology Source Type: research

Effect of Inflammation on the Process of Stroke Rehabilitation and Poststroke Depression
Conclusions Stroke comprises ischemic stroke and ICH. The immuno-inflammatory process is involved in neural plasticity following events such as a hemorrhage or ischemic stroke. After ischemia, astrocytes, microglia, and MDMs play important roles during rehabilitation with the modulation of cytokines or chemokines, such as TNF-α and IL-1. Moreover, MiRNAs are also important posttranscriptional regulators in these glial mitochondrial responses to cerebral ischemia. ICH involves processes similar and different to those seen in ischemia, including neuronal injury, astrocytic and microglial/macrophage activation, and n...
Source: Frontiers in Psychiatry - April 10, 2019 Category: Psychiatry Source Type: research

Anxiety in Patients With Acute Ischemic Stroke: Risk Factors and Effects on Functional Status
Conclusion: Depressive symptoms are the major correlates of PSA while more severe PSA is associated with poorer ADL and health-related QOL. Acute lesions involving CHWM may correlate with PSA in ischemic stroke patients with mild-to-moderate neurologic deficits, supporting a lesion-location hypothesis in PSA.IntroductionAnxiety is prevalent after stroke and occurs in about one-quarter of stroke survivors (1, 2). Poststroke anxiety (PSA) may have a negative impact on quality of life (QOL) of stroke survivors, affecting their rehabilitation (3). Furthermore, one prospective study found that severe anxiety symptoms were assoc...
Source: Frontiers in Psychiatry - April 16, 2019 Category: Psychiatry Source Type: research

A Post-hoc Study of D-Amino Acid Oxidase in Blood as an Indicator of Post-stroke Dementia
In conclusion, our data support that plasma DAO levels were increased in PSD patients and correlated with brain WMH, independent of age, gender, hypertension, and renal function. Plasma DAO levels may therefore aid in PSD diagnosis. Introduction Stroke is a risk factor for both vascular dementia and Alzheimer's disease (1, 2). Functional recovery develops over the course of 26 weeks after a stroke (3), but the survivors are often left with disabilities. In addition to the sequelae of acute neuronal damage, the 1-year post-stroke dementia (PSD) rates after first-ever and recurrent stroke are ~10 and 30...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research

Intravenous Thrombolysis in Posterior Circulation Stroke
Conclusions: Up to date, no data about PCIS and IVT are available from RTCs. Based on limited results from retrospective clinical studies and case series, IVT is safer for use in PCIS than in ACIS. Patients with brainstem ischemia, vertebral artery occlusion, and absence of basilar or posterior cerebral artery occlusion could be considered for treatment with IVT even in borderline cases. Time to IVT in PCIS seems to be a less crucial factor than in ACIS. IVT for PCIS may be beneficial even after 4.5 h from symptom onset. Introduction History of Intravenous Thrombolysis—The Most Relevant Studies Intravenous...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research

Postreperfusion Blood Pressure Variability After Endovascular Thrombectomy Affects Outcomes in Acute Ischemic Stroke Patients With Poor Collateral Circulation
Conclusion: Postreperfusion BP management by decreasing BPV may have influence on improving clinical outcome in cases of poor collateral circulation among patients achieving successful recanalization after ERT. Introduction Endovascular recanalization therapy (ERT) has been adopted as standard stroke care in patients with acute ischemic stroke (1–6). Time to recanalization and degree of recanalization are the most important predictors of clinical outcomes after ERT (7). Before recanalization, an effort to reduce the time from symptom onset to reperfusion is critical for penumbral salvage. After recanalization...
Source: Frontiers in Neurology - April 11, 2019 Category: Neurology Source Type: research