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Monitoring risk and preventing ischemic stroke in the very old
This article examines current guidelines and evidence regarding medical management, lifestyle changes, and psychosocial interactions that can contribute to the primary and secondary prevention of ischemic stroke in the very old.AREAS COVERED: The authors conducted a literature search for ischemic stroke prevention and risk assessment in the elderly via PubMed. Furthermore, they describe current strategies for monitoring risk and preventing ischemic stroke in the elderly population.EXPERT OPINION: Ischemic stroke poses a significant health risk to the elderly, with prevention relying on managing modifiable risk factors such...
Source: Expert Review of Neurotherapeutics - August 4, 2023 Category: Neurology Authors: Mychael Delgardo Grant Rabin Thilan Tudor Anthony J Tang Geoffrey Reeves E Sander Connolly Source Type: research

Predictors of Percutaneous Endoscopic Gastrostomy Tube Placement in Middle Cerebral Artery Acute Ischemic Stroke and Stroke Laterality (P02.018)
CONCLUSIONS: Our study indicates that high NIHSS on admission, aspiration pneumonia and inability to undergo first swallow evaluation are independent predictors of PEG placement in patients with acute MCA strokes. This knowledge can be used for early identification of patients that require PEG tube placement to provide prompt nutritional support.Supported by: Hartford Hospital Research Center grant.Disclosure: Dr. San Luis has nothing to disclose. Dr. McCullough has received personal compensation for activities with Genentech, Inc. Dr. Ollenschleger has nothing to disclose. Dr. Staff has nothing to disclose. Dr. Fortunato ...
Source: Neurology - February 14, 2013 Category: Neurology Authors: San Luis, C., McCullough, L., Ollenschleger, M., Staff, I., Fortunato, G. Tags: P02 Cerebrovascular Disease II Source Type: research

Detection of Presymptomatically Latent Lesions Developing into Stroke-Like Episodes by Arterial Spin-Labeling Perfusion MRI in MELAS Patients (P03.162)
CONCLUSIONS: These findings suggest that regional ASL hyperperfusion in the presymptomatic phase precedes the appearance of upcoming stroke-like lesions, and that presymptomatic SEs had already occurred several months before the onset of clinical symptoms. ASL imaging has great potential for detecting presymptomatic stroke-like lesions and predicting the emergence of SEs.Supported by: In part by Grants-in-Aid for the Scientific Research on Innovative Areas from the Ministry of Education, Culture, Sports, Science and Technology of Japan and Young Scientists (B) from the Japan Society for the Promotion of Science, and the Re...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Ikawa, M., Kimura, H., Muramatsu, T., Matsunaga, A., Tsujikawa, T., Yamamoto, T., Kosaka, N., Kinoshita, K., Yamamura, O., Hamano, T., Nakamoto, Y., Yoneda, M. Tags: P03 Cerebrovascular Disease III Source Type: research

Correlates of health-related quality of life in African American and Caucasian stroke caregivers.
Objective: Stroke is a leading cause of long-term disability in the United States. Family caregivers are susceptible to negative outcomes as a result of their caregiving role. A stress process model was utilized to identify characteristics of stroke caregivers who are at risk for poor physical and mental health-related quality of life (QOL). Research Method: Individuals who experienced an incident stroke event within the previous year were identified from a larger epidemiologic study of stroke incidence. These stroke survivors were enrolled in the Caring for Adults Recovering from the Effects of Stroke (CARES) study along ...
Source: Rehabilitation Psychology - February 25, 2013 Category: Rehabilitation Authors: Clay, Olivio J.; Grant, Joan S.; Wadley, Virginia G.; Perkins, Martinique M.; Haley, William E.; Roth, David L. Source Type: research

Inpatient Stroke Rehabilitation Lengths of Stay in Canada Derived From the National Rehabilitation Reporting System, 2008 and 2009
Conclusions: FIM motor function scores at admission along with age and geographic region best predicted rehabilitation LOS. These variables explained 20% of the variation in LOSs. Despite regional differences in LOSs, patient characteristics were similar between regions. Other nonpatient factors not captured in these data may contribute to a greater extent in determining stroke rehabilitation LOS.
Source: Archives of Physical Medicine and Rehabilitation - September 3, 2013 Category: Rehabilitation Authors: Chris Grant, Charles H. Goldsmith, Hubert A. Anton Tags: Original Articles Source Type: research

Social Relationships, Serum Brain-Derived Neurotrophic Factor, and the Risk for Stroke and Dementia: The Framingham Heart Study (P1.098)
Conclusions: In our large community sample, greater social support was associated with increased BDNF levels and, in certain dimensions of support, reduced risk of subsequent dementia and stroke. Further study of the biological and social mechanisms through which support from social networks reduce these risks is needed to determine whether relatively simple social interventions may help protect against age-related neurologic disease. Study Supported by: Boston University School of Medicine, a contract from NHLBI (N01-HC 25195), and by grants from the NINDS (NS017950) and NIA (AG031287, AG008122, AG033193).Disclosure: Dr. ...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Salinas, J. Tags: Epidemiology of Aging and Dementias Source Type: research

Factors Determining Consent in a Randomized Trial of Intra-arterial Stem Cell Therapy for Sub-Acute Ischemic Stroke (P2.386)
Conclusions: There was a relatively high rate of consent among eligible patients in the first US intra-arterial trial of stem cell therapy for stroke. Approaching LAR for consent was found not to influence consenting rates.Disclosure: Dr. Ramdas has nothing to disclose. Dr. Pafford has nothing to disclose. Dr. Haussen has nothing to disclose. Dr. McBee has nothing to disclose. Dr. Rutledge has nothing to disclose. Dr. Huang has received personal compensation for activities with Aldagen/Cytomedix and Dart Neuroscience as a consultant. Dr. Savitz has received research support from NIH T32 grant. Dr. Hinson has nothing to dis...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Ramdas, K., Pafford, R., Haussen, D., McBee, D., Rutledge, J., Huang, D., Savitz, S., Hinson, J., Yavagal, D. Tags: Research Methodology and Patient Education Source Type: research

Modeling the Impact of Interhospital Transfer Protocol Design on Mechanical Thrombectomy Eligibility and Outcomes in a Large Metropolitan Area (S25.005)
Conclusions:Optimizing IHT networks requires balancing the efficiency gains of transferring to affiliated hospitals with the travel delays resulting from bypassing nearby MT-capable centers.Study Supported by: Babak Navi was supported by grants from the NINDS (K23NS091395) and the Florence Gould Endowment for Discovery in Stroke. Hooman Kamel was supported by grants from the NINDS (K23NS082367) and the Michael Goldberg Stroke Research Fund.Disclosure: Dr. Parikh has nothing to disclose. Dr. Chatterjee has nothing to disclose. Dr. Merkler has nothing to disclose. Dr. Gialdini has nothing to disclose. Dr. Kummer has nothing ...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Parikh, N., Chatterjee, A., Merkler, A., Gialdini, G., Kummer, B., Mir, S., Lerario, M., Navi, B., Kamel, H. Tags: Cerebrovascular Disease and Interventional Neurology: Prehospital and Emergency Department Ischemic Stroke Care Source Type: research

Long-term Risk of Complications after Percutaneous Transcatheter Closure of Patent Foramen Ovale (S51.003)
Conclusions:Approximately 1 in 6 patients who undergo percutaneous transcatheter closure of PFO after stroke or transient ischemic attack experience a serious complication or death within 5 years.Study Supported by:Dr. Gialdini is supported by the Feil Family Foundation.Dr. Navi is supported by NIH grant K23NS091395 and the Florence Gould Endowment for Discovery in Stroke.Dr. Iadecola is supported by NIH grants R37NS089323-02, R01NS034179-21, R01NS037853-19, and R01 NS073666-04.Dr. Kamel is supported by NIH grants K23NS082367 and R01NS097443 as well as the Michael Goldberg Research Fund.Disclosure: Dr. Merkler has nothing ...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Merkler, A., Gialdini, G., Yaghi, S., Okin, P., Iadecola, C., Navi, B., Kamel, H. Tags: Cerebrovascular Disease and Interventional Neurology: Stroke Prevention and Translation Source Type: research

Stroke-associated pattern of gene expression previously identified by machine-learning is diagnostically robust in an independent patient population
The objective of this study was to assess the diagnostic capacity and temporal stability of this stroke-associated transcriptional signature in an independent patient population. Publicly available whole blood microarray data generated from 23 ischemic stroke patients at 3, 5, and 24h post-symptom onset, as well from 23 cardiovascular disease controls, were obtained via the National Center for Biotechnology Information Gene Expression Omnibus. Expression levels of the ten candidate genes (ANTXR2, STK3, PDK4, CD163, MAL, GRAP, ID3, CTSZ, KIF1B, and PLXDC2) were extracted, compared between groups, and evaluated for their dis...
Source: Genomics Data - September 2, 2017 Category: Genetics & Stem Cells Source Type: research