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Total 908 results found since Jan 2013.

Does caregiver well-being predict stroke survivor depressive symptoms? A mediation analysis.
Conclusions: Findings indicate that stroke survivor impairments and problems may affect family caregivers and stroke survivors and a high level of caregiver distress may result in poorer outcomes for stroke survivors. Results highlight the likely importance of intervening with both stroke survivors and family caregivers to optimize recovery after stroke. PMID: 23340070 [PubMed - in process]
Source: Topics in Stroke Rehabilitation - January 1, 2013 Category: Neurology Authors: Grant JS, Clay OJ, Keltner NL, Haley WE, Wadley VG, Perkins MM, Roth DL Tags: Top Stroke Rehabil Source Type: research

Arterial Spin Labeling Perfusion Magnetic Resonance Imaging Performed in Acute Perinatal Stroke Reveals Hyperperfusion Associated With Ischemic Injury Clinical Sciences
Conclusions— Perfusion-weighted imaging can be obtained in neonates with acute stroke and often reveals hyperperfusion in the infarct core. Penumbra in arterial ischemic stroke is seldom found. Hyperperfusion may be caused by poststroke reperfusion or to neuronal hyperexcitability of stroke-associated seizure. Its identification may be useful for consideration of therapy for acute neonatal stroke.
Source: Stroke - May 22, 2016 Category: Neurology Authors: Watson, C. G., Dehaes, M., Gagoski, B. A., Grant, P. E., Rivkin, M. J. Tags: Pediatrics, Magnetic Resonance Imaging (MRI), Cerebrovascular Disease/Stroke, Ischemic Stroke Clinical Sciences Source Type: research

Extended-Release Niacin Therapy and Risk of Ischemic Stroke in Patients With Cardiovascular Disease: The Atherothrombosis Intervention in Metabolic Syndrome With Low HDL/High Triglycerides: Impact on Global Health Outcome (AIM-HIGH) Trial Major Clinical Trials
Conclusions— Although there were numerically more ischemic strokes with addition of ERN to simvastatin that reached nominal significance, the number was small, and multivariable analysis accounting for known risk factors did not support a significant association between niacin and ischemic stroke risk. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00120289.
Source: Stroke - September 23, 2013 Category: Neurology Authors: Teo, K. K., Goldstein, L. B., Chaitman, B. R., Grant, S., Weintraub, W. S., Anderson, D. C., Sila, C. A., Cruz-Flores, S., Padley, R. J., Kostuk, W. J., Boden, W. E., on behalf of the AIM-HIGH Investigators Tags: Secondary prevention, Risk Factors, Acute Cerebral Infarction, Other Stroke Treatment - Medical Major Clinical Trials Source Type: research

Somatosensory stimulation to improve hand and upper limb function after stroke-a systematic review with meta-analyses.
Conclusion Current low- to moderate-quality evidence suggests somatosensory stimulation is not effective in improving upper limb motor impairment or activity after stroke. PMID: 29050540 [PubMed - as supplied by publisher]
Source: Topics in Stroke Rehabilitation - October 20, 2017 Category: Neurology Authors: Grant VM, Gibson A, Shields N Tags: Top Stroke Rehabil Source Type: research

Minimal Clinically Important Difference for Safe and Simple Novel Acute Ischemic Stroke Therapies Clinical Sciences
Conclusions—Stroke expert responses to MCID surveys are affected by anchoring and centrality bias. When survey design takes these into account, the expert-derived MCID for a safe acute ischemic stroke treatment is 1.1% to 1.5%, in accord with actual physician behavior in guideline writing and clinical practice. This revised MCID value can guide clinical trial design and grant-funding and regulatory agency decisions.
Source: Stroke - October 23, 2017 Category: Neurology Authors: Jessica S. Cranston, Brett D. Kaplan, Jeffrey L. Saver Tags: Ischemic Stroke, Neuroprotectants Original Contributions Source Type: research

Arterial Obstruction on Computed Tomographic or Magnetic Resonance Angiography and Response to Intravenous Thrombolytics in Ischemic Stroke Clinical Sciences
Conclusions—Intravenous thrombolytics provide benefit to stroke patients with computed tomographic angiography or magnetic resonance angiography evidence of arterial obstruction, but the sample was underpowered to demonstrate significant treatment benefit or harm among patients with apparently patent arteries.Clinical Trial Registration—URL: http://www.isrctn.com. Unique identifier: ISRCTN25765518.
Source: Stroke - January 22, 2017 Category: Neurology Authors: Grant Mair, Rudiger von Kummer, Alessandro Adami, Philip M. White, Matthew E. Adams, Bernard Yan, Andrew M. Demchuk, Andrew J. Farrall, Robin J. Sellar, Eleni Sakka, Jeb Palmer, David Perry, Richard I. Lindley, Peter A.G. Sandercock, Joanna M. Wardlaw Tags: Angiography, Meta Analysis, Ischemic Stroke Original Contributions Source Type: research

Prehospital Emergency Care in Childhood Arterial Ischemic Stroke Brief Report
Background and Purpose—Immediately calling an ambulance is the key factor in reducing time to hospital presentation for adult stroke. Little is known about prehospital care in childhood arterial ischemic stroke (AIS). We aimed to determine emergency medical services call-taker and paramedic diagnostic sensitivity and to describe timelines of care in childhood AIS.Methods—This is a retrospective study of ambulance-transported children aged
Source: Stroke - March 27, 2017 Category: Neurology Authors: Belinda Stojanovski, Paul T. Monagle, Ian Mosley, Leonid Churilov, Fiona Newall, Grant Hocking, Mark T. Mackay Tags: Basic Science Research, Cerebrovascular Disease/Stroke, Ischemic Stroke Brief Reports Source Type: research

Recurrent Stroke after Silent Brain Infarction in Patients with Primary Brain Tumors (S51.007)
Conclusions:The short-term risk of recurrent ischemic stroke in patients with PBTs was substantial and the risk was comparable whether the stroke was silent or symptomatic.Study Supported by: Babak Navi was supported by grants from the NINDS (K23NS091395) and the Florence Gould Endowment for Discovery in Stroke. Hooman Kamel was supported by grants from the NINDS (K23NS082367) and the Michael Goldberg Stroke Research Fund.Disclosure: Dr. Parikh has nothing to disclose. Dr. Burch has nothing to disclose. Dr. Kamel has received personal compensation for activities with Genentech as a speaker. Dr. Kamel has received personal ...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Parikh, N., Burch, J., Kamel, H., DeAngelis, L., Navi, B. Tags: Cerebrovascular Disease and Interventional Neurology: Stroke Prevention and Translation Source Type: research

Associations between Parkinson Disease and Stroke (S51.006)
Conclusions:Among Medicare beneficiaries, the relationships between stroke and PD were similar to those between stroke and AD. As in AD, a link may exist between cerebrovascular disease and PD.Study Supported by: Hooman Kamel was supported by grants from the NINDS (K23NS082367) and the Michael Goldberg Stroke Research Fund. Babak Navi was supported by grants from the NINDS (K23NS091395) and the Florence Gould Endowment for Discovery in Stroke.Disclosure: Dr. Kummer has nothing to disclose. Dr. Aaroe has nothing to disclose. Dr. Kamel has received personal compensation for activities with Genentech as a speaker. Dr. Kamel h...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Kummer, B., Aaroe, A., Kamel, H., Iadecola, C., Navi, B. Tags: Cerebrovascular Disease and Interventional Neurology: Stroke Prevention and Translation Source Type: research

Trends in Substance Abuse Preceding Stroke in Young Adults: An Update (S55.004)
Conclusions: Substance abuse is an important and highly prevalent risk factor for stroke in young adults. More efforts are needed to curb the increasing relationship between stroke in young adults and illicit drugs, alcohol, and smoking.Study supported by: NIH NINDS grant R01 NS30678Disclosure: Dr. De Los Rios La Rosa has nothing to disclose. Dr. Kleindorfer has received personal compensation for activities with Genentech, Inc. and for medicolegal case review. Dr. Khoury has nothing to disclose. Dr. Broderick has received research support from Significant, Genentech Inc., and Schering-Plough Corporation, and the National I...
Source: Neurology - April 9, 2014 Category: Neurology Authors: De Los Rios La Rosa, F., Kleindorfer, D., Khoury, J., Broderick, J., Alwell, K., Moomaw, C., Khatri, P., Adeoye, O., Flaherty, M., Woo, D., Eilerman, J., Ferioli, S., Kissela, B. Tags: Pediatric Stroke and Stroke in the Young Source Type: research

Orosomucoid-1 Protein Dynamics Following Ischemic Stroke in Humans and Mice (P1.265)
Conclusions:ORM-1 is a sexually dimorphic protein involved in the early (<24 hour) response to ischemic stroke. This research demonstrates that sex differences exist in post-stroke ORM-1 protein dynamics, and serves as an initial step in determining the mechanism of ORM-1 in the ischemic stroke response and its potential as a future therapeutic target for both sexes.Study Supported by:NIH Grant 5 R01 NS055215 09, and Hartford Hospital, Hartford, CT.Additional thanks to Sharon DiMauro, Lori Capozzi, and to the Scientific Research Committee at the University of Connecticut School of Medicine.Disclosure: Dr. Mistry has not...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Mistry, H., Levy, M., Roy-OReilly, M., McCullough, L. Tags: Genetic Stroke Syndromes, Biomarkers, and Translational/Basic Research Source Type: research

COLADAS: Caribbean Origin Latin Americans Disparities in Acute Stroke (S4.002)
Conclusions: Our study reveals intrinsic sex differences that may imply under treatment. Understanding the reasons underlying these "sex-gaps" is critical. Study Supported By: Award Number Grants 5S21MD000242 and 5S21MD000138, from the National Center for Minority Health and Health Disparities, National Institutes of Health (NCMHD-NIH).Disclosure: Dr. Teron Molina has nothing to disclose. Dr. Rodríguez Centeno has nothing to disclose. Dr. Santiago has nothing to disclose. Dr. López Valentín has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Teron Molina, I., Rodriguez Centeno, A., Santiago, F., Lopez Valentin, M. Tags: Health Disparities and Sex Differences in Stroke Source Type: research

Does Transferring Patients to Stroke Centers Increase Length of Stay (P2.313)
Conclusions: There was no difference in LOS or any clinical outcomes between the ED and transferred patients. Additionally, transferred patients did not receive more advanced procedures such as intra-arterial therapy or hemicraniectomy. Further studies exploring non-tPA patients and transient ischemic attack patients would be informative, as well as non-home, discharge location relative to the patient’s residence.Disclosure: Dr. Cossey has nothing to disclose. Dr. Bozorgui has nothing to disclose. Dr. Jagolino has nothing to disclose. Dr. Vahidy has nothing to disclose. Dr. Wu has received personal compensation for a...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Cossey, T., Bozorgui, S., Jagolino, A., Vahidy, F., Wu, T. C., Savitz, S. Tags: Stroke Systems of Care Source Type: research

Thrombolytic Utilization in Ischemic Stroke Is Significantly Higher in US Hospitals with Neurology Residency Program (S02.006)
CONCLUSIONS: Stroke care at NR hospitals is associated with an increased thrombolytic utilization rate. The increased tPA utilization at NR between 2002-2006 may be related to the rapid increase in Primary Stroke Centers across the country.Disclosure: Dr. Moradiya has nothing to disclose. Dr. Grant has nothing to disclose. Dr. Valsamis has nothing to disclose. Dr. Levine has received personal compensation in an editorical capacity for MEDLINK.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Moradiya, Y., Grant, J., Valsamis, H., Levine, S. Tags: S02 Acute Stroke Therapy Source Type: research

Optical Bedside Monitoring of Cerebral Blood Flow in Acute Ischemic Stroke Patients during Head of Bed Manipulation (P4.216)
CONCLUSIONS: A lower HOB angle results in an increase in cortical CBF without a significant change in arterial flow velocity in the setting of acute stroke, but there is variability across patients in this response. Bedside CBF monitoring with DCS provides a potential means to individualize interventions designed to optimize CBF in acute ischemic stroke.Disclosure: Dr. Favilla has nothing to disclose. Dr. Mesquita has nothing to disclose. Dr. Mullen has nothing to disclose. Dr. Durduran has nothing to disclose. Dr. Kim has nothing to disclose. Dr. Minkoff has nothing to disclose. Dr. Kasner has received personal compensati...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Favilla, C., Mesquita, R., Mullen, M., Durduran, T., Kim, M., Minkoff, D., Kasner, S., Joel, G., Yodh, A., Detre, J. Tags: Cerebrovascular Disease and Interventional Neurology: Acute Stroke Endovascular Source Type: research